Urine TNF-α and IL-9 for clinical diagnosis of acute interstitial nephritis
Open accessAbstract
BACKGROUND: Clinical diagnosis of acute interstitial nephritis (AIN) is challenging because of lack of a diagnostic biomarker and requires a kidney biopsy. We hypothesized that AIN is mediated by specific T cell subsets such that specific T cell cytokine levels could serve as biomarkers to distinguish AIN from other causes of acute kidney disease (AKD). METHODS: We enrolled consecutive sampling participants who underwent a kidney biopsy for AKD evaluation at 2 centers between 2015 and 2018. Three pathologists independently established AIN diagnosis through review of kidney biopsies. Through univariable and multivariable analysis of 12 selected urine and plasma cytokines, we identified 2 that were diagnostic of AIN. RESULTS: Of the 218 participants, 32 (15%) were diagnosed with AIN by all 3 pathologists. Participants with AIN had consistently higher levels of urine TNF-α and IL-9 than those with other diagnoses, including acute tubular injury, glomerular diseases, and diabetic kidney disease, and those without any kidney disease. As compared with participants in the lowest quartile, we noted higher odds of AIN in participants in the highest quartiles of TNF-α levels (adjusted odds ratio, 10.9 [1.8, 65.9]) and IL-9 levels (7.5 [1.2, 45.7]) when controlling for blood eosinophils, leukocyturia, and proteinuria. Addition of biomarkers improved area under receiver operating characteristic curve over clinicians’ prebiopsy diagnosis (0.84 [0.78, 0.91]) vs. 0.62 [(0.53, 0.71]) and a model of current tests (0.84 [0.76, 0.91] vs. 0.69 [0.58, 0.80]). CONCLUSIONS: Inclusion of urinary TNF-α and IL-9 improves discrimination over clinicians’ prebiopsy diagnosis and currently available tests for AIN diagnosis. FUNDING: Supported by NIH awards K23DK117065, T32DK007276, K24DK090203, K23DK097201, R01DK113191, UG3-DK114866, P30DK079310; the Robert E. Leet and Clara Guthrie Patterson Trust; and American Heart Association award 18CDA34060118.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IL-9 and IL-5 are implicated in allergic responses and promote mast cell accumulation, which is a source of TNF-α.
“As IL-9 and IL-5 are implicated in allergic responses and promotes mast cell accumulation, which in turn is a source of TNF-α [60, 61, 95–98]”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [60]
Moledina et al. observed higher levels of urinary CXCL9, IL-9 and TNF-α in patients with AIN.
“Despite the findings of Moledina et al. [60, 62, 94], who observed a higher level of urinary C-X-C motif ligand 9 (CXCL9), interleukin-9 (IL-9) and tumor necrosis factor-α (TNF-α) levels in patients with AIN”
From The diagnosis of acute interstitial nephritis caused by infection versus antibiotic-induced interstitial nephritis: a narrative review (2024) · cites this paper as [60]
Cites
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Wanchoo, R., Karam, S., Uppal, N. N., Barta, V. S., Deray, G., Devoe, C., Launay‐Vacher, V., Jhaveri, K. D., & on behalf of Cancer and Kidney International Network Workgroup on Immune Checkpoint Inhibitors (2017) · American Journal of Nephrology · doi:10.1159/000455014 · Cited by 15,314 · see citing works
KDIGO Clinical Practice Guidelines for Acute Kidney Injury
Khwaja, A. (2012) · Nephron Clinical Practice · doi:10.1159/000339789 · Cited by 8,039 · see citing works
Pencina, M. J., D' Agostino, R. B., D' Agostino, R. B., & Vasan, R. S. (2008) · Statistics in Medicine · doi:10.1002/sim.2929 · Cited by 6,493 · see citing works
(2012) · Kidney International Supplements · doi:10.1038/kisup.2012.1 · Cited by 4,326 · see citing works
16., O. B. O. T. A. D. Q. I. W., Chawla, L. S., Bellomo, R., Bihorac, A., Goldstein, S. L., Siew, E. D., Bagshaw, S. M., Bittleman, D., Cruz, D., Endre, Z., et al. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.2 · Cited by 1,537 · see citing works
Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin
Gordon, J., & Galli, S. J. (1990) · Nature · doi:10.1038/346274a0 · Cited by 989 · see citing works
Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease
Lazarus, B., Chen, Y., Wilson, F. P., Sang, Y., Chang, A. R., Coresh, J., & Grams, M. E. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.7193 · Cited by 728 · see citing works
Self-citationLarge sample variance of kappa in the case of different sets of raters.
Fleiss, J. L., Nee, J. C. M., & Landis, J. R. (1979) · Psychological Bulletin · doi:10.1037/0033-2909.86.5.974 · Cited by 398 · see citing works
Biopsy-proven acute interstitial nephritis, 1993-2011: a case series
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S., Fidler, M. E., & Nasr, S. H. (2014) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2014.04.027 · Cited by 337 · see citing works
Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD
Xie, Y., Bowe, B. C., Li, T., Xian, H., Balasubramanian, S., & Al‐Aly, Z. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2015121377 · Cited by 334 · see citing works
Shirali, A. C., Perazella, M. A., & Gettinger, S. N. (2016) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2016.02.057 · Cited by 290 · see citing works
Self-citationChen, C., Lee, J., Liu, B., Ohta, S., Wang, P.-Y., Kartashov, A. V., Mugge, L. A., Abonia, J. P., Barski, A., Izuhara, K., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.08.020 · Cited by 212 · see citing works
Interleukin-9 Is Required for Allergic Airway Inflammation Mediated by the Cytokine TSLP
Yao, W., Zhang, Y., Jabeen, R., Nguyen, E., Wilkes, D. S., Tepper, R. S., Kaplan, M. H., & Zhou, B. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.007 · Cited by 185 · see citing works
Nochaiwong, S., Ruengorn, C., Awiphan, R., Koyratkoson, K., Chaisai, C., Noppakun, K., Chongruksut, W., & Thavorn, K. (2017) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfw470 · Cited by 185 · see citing works
Banff Histopathological Consensus Criteria for Preimplantation Kidney Biopsies
Liapis, H., Gaut, J. P., Klein, C. L., Bagnasco, S. M., Kraus, E. S., Farris, A. B., Honsová, E., Perkowska‐Ptasińska, A., David, D., Goldberg, J. C., et al. (2016) · American Journal of Transplantation · doi:10.1111/ajt.13929 · Cited by 169 · see citing works
Involvement of Drug-Specific T Cells in Acute Drug-Induced Interstitial Nephritis
Spanou, Z., Keller, M., Britschgi, M., Yawalkar, N., Fehr, T., Neuweiler, J., Gugger, M., Mohaupt, M., & Pichler, W. J. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050418 · Cited by 151 · see citing works
Utility of Urine Eosinophils in the Diagnosis of Acute Interstitial Nephritis
Muriithi, A. K., Nasr, S. H., & Leung, N. (2013) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.01330213 · Cited by 148 · see citing works
Clinical characteristics, causes and outcomes of acute interstitial nephritis in the elderly
Muriithi, A. K., Leung, N., Valeri, A. M., Cornell, L. D., Sethi, S. M., Fidler, M. E., & Nasr, S. H. (2014) · Kidney International · doi:10.1038/ki.2014.294 · Cited by 136 · see citing works
Godfraind, C., Louahed, J., Faulkner, H., Vink, A., Warnier, G., Grencis, R. K., & Renauld, J. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.8.3989 · Cited by 127 · see citing works
PPIs and kidney disease: from AIN to CKD
Moledina, D. G., & Perazella, M. A. (2016) · Journal of Nephrology · doi:10.1007/s40620-016-0309-2 · Cited by 107 · see citing works
Self-citationAssessment of KDIGO Definitions in Patients with Histopathologic Evidence of Acute Renal Disease
Chu, R., Li, C., Wang, S., Zou, W.-Z., Liu, G., & Yang, L. (2014) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06150613 · Cited by 104 · see citing works
Kidney Biopsy–Related Complications in Hospitalized Patients with Acute Kidney Disease
Moledina, D. G., Luciano, R. L., Kukova, L., Chan, L., Saha, A., Nadkarni, G. N., Alfano, S. L., Wilson, F. P., Perazella, M. A., & Parikh, C. R. (2018) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04910418 · Cited by 91 · see citing works
Self-citationDiagnosing drug-induced AIN in the hospitalized patient: A challenge for the clinician
Perazella, M. A. (2014) · Clinical Nephrology · doi:10.5414/cn108301 · Cited by 81 · see citing works
Self-citationClinical Approach to Diagnosing Acute and Chronic Tubulointerstitial Disease
Perazella, M. A. (2017) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2016.08.003 · Cited by 79 · see citing works
Self-citationBarisoni, L. M. C., Troost, J. P., Nast, C. C., Bagnasco, S. M., Ávila-Casado, C., Hodgin, J. B., Palmer, M., Rosenberg, A. Z., Gasim, A., Liensziewski, C., et al. (2016) · Modern Pathology · doi:10.1038/modpathol.2016.58 · Cited by 67 · see citing works
Association Between the Use of Proton Pump Inhibitors and the Risk of ESRD in Renal Diseases
Peng, Y., Lin, C., Yeh, H., Chang, C., Wu, Y.-L., & Kao, C. (2016) · Medicine · doi:10.1097/md.0000000000003363 · Cited by 55 · see citing works
Serum Interleukin‐9 Levels Are Associated With Clinical Severity in Children With Atopic Dermatitis
Ciprandi, G., AMICI, M. D., Giunta, V., Marseglia, A., & Marseglia, G. L. (2012) · Pediatric Dermatology · doi:10.1111/j.1525-1470.2012.01766.x · Cited by 50 · see citing works
Kim, Y. S., Ko, H., Kang, N., Song, C., Zhang, X., Chung, W., Kim, J., Choi, I., Park, Y., Kim, G., et al. (2007) · European Journal of Immunology · doi:10.1002/eji.200636612 · Cited by 48 · see citing works
Risk of percutaneous renal biopsy of native kidneys in the evaluation of acute kidney injury
Korbet, S. M., Gashti, C. N., Evans, J. K., & Whittier, W. L. (2018) · Clinical Kidney Journal · doi:10.1093/ckj/sfy048 · Cited by 45 · see citing works
(1989) · PubMed · Cited by 31 · see citing works
A Survey of Patient Attitudes Toward Participation in Biopsy-Based Kidney Research
Moledina, D. G., Cheung, B. H., Kukova, L., Luciano, R. L., Peixoto, A. J., Wilson, F. P., Alfano, S. L., & Parikh, C. R. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.11.008 · Cited by 12 · see citing works
Self-citationZand, L., Monaghan, M., Griffin, B. R., Wagner, S. J., Criaci, I. M., Kamal, A., Raissian, Y., Grande, J. P., Lim, K. G., & Garovic, V. D. (2015) · Clinical Nephrology · doi:10.5414/cn108254 · Cited by 12 · see citing works
Nadkarni, P. M., Kemp, R., & Parikh, C. R. (2011) · Journal of Clinical Bioinformatics · doi:10.1186/2043-9113-1-22 · Cited by 10 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Ostermann, M., Zarbock, A., Goldstein, S. L., KASHANI, K. B., Macedo, E. M., Murugan, R., Bell, M., Forni, L. G., Guzzi, L. M., Joannidis, M., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.19209 · Cited by 701 · see citing works
Drug-Induced Acute Kidney Injury
Perazella, M. A., & Rosner, M. H. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.11290821 · Cited by 357 · see citing works
Self-citationCurrent concepts and advances in biomarkers of acute kidney injury
Wen, Y., & Parikh, C. R. (2021) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2021.1879000 · Cited by 229 · see citing works
Self-citationThe Promise of Tubule Biomarkers in Kidney Disease: A Review
Ix, J. H., & Shlipak, M. G. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2021.03.026 · Cited by 182 · see citing works
Immune checkpoint inhibitor nephrotoxicity: what do we know and what should we do?
Perazella, M. A., & Shirali, A. C. (2019) · Kidney International · doi:10.1016/j.kint.2019.07.022 · Cited by 173 · see citing works
Self-citationBiomarkers in acute kidney injury
Ostermann, M., Legrand, M. M., Meersch, M., Srisawat, N., Zarbock, A., & Kellum, J. A. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01360-9 · Cited by 147 · see citing works
AKI!Now Initiative: Recommendations for Awareness, Recognition, and Management of AKI
Liu, K. D., Goldstein, S. L., Vijayan, A., Parikh, C. R., KASHANI, K. B., Okusa, M. D., Agarwal, A., Cerdá, J., & on behalf of the AKI!Now Initiative of the American Society of Nephrology (2020) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.15611219 · Cited by 136 · see citing works
Self-citationHu, X., Li, Z., Lin, R., Shan, J.-Q., Yu, Q., Wang, R., Liao, L., Yan, W., Zhen, W., Shang, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634690 · Cited by 127 · see citing works
Advances in the diagnosis of early biomarkers for acute kidney injury: a literature review
Yang, H., Chen, Y., He, J., Li, Y., & Feng, Y. (2025) · BMC Nephrology · doi:10.1186/s12882-025-04040-3 · Cited by 98 · see citing works
Moledina, D. G., Simonov, M., Yamamoto, Y., Alausa, J., Arora, T., Biswas, A., Cantley, L. G., Ghazi, L., Greenberg, J. H., Hinchcliff, M., et al. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2020.12.007 · Cited by 97 · see citing works
Self-citationImmune-mediated tubule atrophy promotes acute kidney injury to chronic kidney disease transition
Xu, L., Guo, J., Moledina, D., & Cantley, L. (2022) · Nature Communications · doi:10.1038/s41467-022-32634-0 · Cited by 90 · see citing works
Self-citationMoledina, D. G., Obeid, W., Smith, R. N., Rosales, I., Sise, M. E., Moeckel, G., Kashgarian, M., Kuperman, M., Campbell, K. N., Lefferts, S., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci168950 · Cited by 80 · see citing works
Self-citationPrecision management of acute kidney injury in the intensive care unit: current state of the art
Stanski, N. L., Rodrigues, C. E., Strader, M., Murray, P. T., Endre, Z. H., & Bagshaw, S. M. (2023) · Intensive Care Medicine · doi:10.1007/s00134-023-07171-z · Cited by 79 · see citing works
Diagnosis and management of immune checkpoint inhibitor-associated acute kidney injury
Sprangers, B., Leaf, D. E., Porta, C., Soler, M. J., & Perazella, M. A. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00630-8 · Cited by 71 · see citing works
Self-citationLin, J. S., Mamlouk, O., Selamet, U., Tchakarov, A. S., Glass, W. F., Sheth, R. A., Layman, R. M., Dadu, R., Abdel‐Wahab, N., Abdelrahim, M., et al. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1877415 · Cited by 66 · see citing works
Immune Checkpoint Inhibitors and Kidney Toxicity: Advances in Diagnosis and Management
Seethapathy, H. S., Herrmann, S. M., & Sise, M. E. (2021) · Kidney Medicine · doi:10.1016/j.xkme.2021.08.008 · Cited by 65 · see citing works
New biomarkers in acute kidney injury
Rossiter, A., La, A. M., Koyner, J. L., & Forni, L. G. (2023) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408363.2023.2242481 · Cited by 65 · see citing works
Herrmann, S. M., Abudayyeh, A., Gupta, S., Gudsoorkar, P., Klomjit, N., Motwani, S. S., Karam, S., Costa E Silva, V. T., Khalid, S. B., Anand, S., et al. (2025) · Kidney international · doi:10.1016/j.kint.2024.09.017 · Cited by 67 · see citing works
Prognostic Significance of Urinary Biomarkers in Patients Hospitalized With COVID-19
Menez, S. P., Moledina, D. G., Thiessen‐Philbrook, H., Wilson, F. P., Obeid, W., Simonov, M., Yamamoto, Y., Corona‐Villalobos, C. P., Chang, C. T., Garibaldi, B. T., et al. (2021) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2021.09.008 · Cited by 57 · see citing works
Self-citationFarooqui, N., Zaidi, M., Vaughan, L. E., McKee, T. D., Ahsan, E., Pavelko, K. D., Villasboas, J. C., Markovic, S. N., Taner, T., Leung, N., et al. (2022) · Kidney International Reports · doi:10.1016/j.ekir.2022.11.020 · Cited by 57 · see citing works
Birkelo, B. C., Pannu, N., & Siew, E. D. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.14181021 · Cited by 56 · see citing works
Adding insult to injury: the spectrum of tubulointerstitial responses in acute kidney injury
Baker, M. L., & Cantley, L. G. (2025) · Journal of Clinical Investigation · doi:10.1172/jci188358 · Cited by 55 · see citing works
Self-citationDumoulin, D. W., Visser, S., Cornelissen, R., van Gelder, T., Vansteenkiste, J., von der Thüsen, J. H., & Aerts, J. G. J. V. (2020) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.04.021 · Cited by 54 · see citing works
Qualls, D. A., Seethapathy, H. S., Bates, H., Tajmir, S., Heidari, P., Endres, P., Reynolds, K. L., Lawrence, D. P., & Sise, M. E. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0820-9 · Cited by 52 · see citing works
Soluble and cell-based markers of immune checkpoint inhibitor-associated nephritis
Sise, M. E., Wang, Q., Seethapathy, H. S., Moreno, D., Harden, D., Smith, R. N., Rosales, I. A., Colvin, R. B., Chute, S., Cornell, L. D., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006222 · Cited by 50 · see citing works
Zarbock, A., Forni, L., Koyner, J., Bell, S., Reis, T., Meersch, M., Bagshaw, S., Fuhmann, D. Y., Liu, K. D., Pannu, N., et al. (2024) · Intensive Care Medicine · doi:10.1007/s00134-024-07560-y · Cited by 46 · see citing works
Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis
Moledina, D. G., Wilson, F. P., Kukova, L., Obeid, W., Luciano, R., Kuperman, M., Moeckel, G. W., Kashgarian, M., Perazella, M. A., Cantley, L. G., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa169 · Cited by 47 · see citing works
Self-citationDefinitions, phenotypes, and subphenotypes in acute kidney injury—Moving towards precision medicine
Rodrigues, C. E., & Endre, Z. H. (2022) · Nephrology · doi:10.1111/nep.14132 · Cited by 44 · see citing works
Baker, M. L., Yamamoto, Y., Perazella, M. A., Dizman, N., Shirali, A. C., Hafez, N., Weinstein, J. N., Simonov, M., Testani, J. M., Kluger, H. M., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004421 · Cited by 42 · see citing works
Self-citationDifferentiating acute interstitial nephritis from acute tubular injury: a challenge for clinicians
Moledina, D. G., & Parikh, C. R. (2019) · Nephron · doi:10.1159/000501207 · Cited by 40 · see citing works
Self-citationUrine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis
Melchinger, H. C., Calderon-Gutierrez, F., Obeid, W., Xu, L., Shaw, M. M., Luciano, R. L., Kuperman, M. B., Moeckel, G. W., Kashgarian, M. J., Wilson, F. P., et al. (2022) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.04360422 · Cited by 39 · see citing works
Self-citationPiscitani, L., Sirolli, V., Liberato, L. D., Morroni, M., & Bonomini, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144878 · Cited by 36 · see citing works
Adam, B., Murakami, N., Reid, G., Du, K., Jasim, R., Boils, C. L., Bu, L., Hill, P. D., Murray, A. G., Renaudin, K., et al. (2021) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.00920121 · Cited by 32 · see citing works
Miao, J., & Herrmann, S. M. (2023) · Clinical Kidney Journal · doi:10.1093/ckj/sfad109 · Cited by 31 · see citing works
Eosinophilia and risk of incident end stage kidney disease
Tariq, A., Okamato, K., Tariq, A., Rosenberg, A. Z., Soliman, K., Ploth, D. W., Atta, M. G., & McMahon, B. A. (2020) · BMC Nephrology · doi:10.1186/s12882-020-1685-3 · Cited by 31 · see citing works
Miao, J., Sise, M. E., & Herrmann, S. M. (2022) · Frontiers in Nephrology · doi:10.3389/fneph.2022.1017921 · Cited by 29 · see citing works
The Road to Precision Medicine for Acute Kidney Injury
Birkelo, B. C., Koyner, J. L., Ostermann, M., & Bhatraju, P. K. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006328 · Cited by 29 · see citing works
Big data-driven precision medicine: Starting the custom-made era of iatrology
Song, C. M., Kong, Y., Huang, L., Luo, H., & Zhu, X. M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110445 · Cited by 26 · see citing works
Moledina, D. G., Eadon, M. T., Calderon, F., Yamamoto, Y., Shaw, M. M., Perazella, M. A., Simonov, M., Luciano, R. L., Schwantes-An, T.-H. L., Moeckel, G. W., et al. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfab346 · Cited by 26 · see citing works
Self-citationThe challenges of acute interstitial nephritis: time to standardize
Moledina, D. G., & Perazella, M. A. (2021) · Kidney360 · doi:10.34067/kid.0001742021 · Cited by 25 · see citing works
Self-citationExome Chip Analyses and Genetic Risk for IgA Nephropathy among Han Chinese
Zhou, S., Tsoi, L. C., Hu, Y., Patrick, M. T., He, K., Berthier, C. C., Li, Y., Wang, Y., Qi, Y., Zhang, Y., et al. (2021) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.06910520 · Cited by 25 · see citing works
Toward Precision Medicine: Exploring the Landscape of Biomarkers in Acute Kidney Injury
Nourié, N., Ghaleb, R., Lefaucheur, C., & Louis, K. (2024) · Biomolecules · doi:10.3390/biom14010082 · Cited by 33 · see citing works
Perioperative Acute Kidney Injury: Diagnosis, Prediction, Prevention, and Treatment
Douville, N. J., Mathis, M. R., Kheterpal, S., Heung, M., Schaub, J. A., Naik, A. S., & Kretzler, M. (2024) · Anesthesiology · doi:10.1097/aln.0000000000005215 · Cited by 27 · see citing works
Assessing the health of the nephron in acute kidney injury
Menez, S. P., & Parikh, C. R. (2019) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000538 · Cited by 23 · see citing works
Self-citationGupta, S., Mistry, K., Alikhan, F. M., Mejia, S. M., Sadarangani, S., Cao, A., Wells, S. L., Koval, E., Liang, C., Ortega, J. L., et al. (2025) · Kidney International · doi:10.1016/j.kint.2025.05.029 · Cited by 23 · see citing works
Self-citationPerazella, M. A. (2020) · Kidney360 · doi:10.34067/kid.0001072019 · Cited by 20 · see citing works
Self-citationDefinitions of acute renal dysfunction: an evolving clinical and biomarker paradigm
Ostermann, M., Wu, V., Sokolov, D., & Lumlertgul, N. (2021) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000000886 · Cited by 20 · see citing works
New Biomarkers in Acute Tubulointerstitial Nephritis: A Novel Approach to a Classic Condition
Martinez Valenzuela, L., Draibe, J., Fulladosa, X., & Torras, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134690 · Cited by 19 · see citing works
Urine proteomics defines an immune checkpoint-associated nephritis signature
Long, J. P., Singh, S., Dong, Y., Yee, C., & Lin, J. S. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-010680 · Cited by 18 · see citing works
Immunotherapy and the Spectrum of Kidney Disease: Should We Individualize the Treatment?
Bermejo, S., Bolufer, M., Riveiro‐Barciela, M., & Soler, M. J. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.906565 · Cited by 18 · see citing works
Biomarkers in acute kidney injury: On the cusp of a new era?
Canney, M., Clark, E. G., & Hiremath, S. S. (2023) · Journal of Clinical Investigation · doi:10.1172/jci171431 · Cited by 18 · see citing works
Nephrotoxicity in the Age of Immune Checkpoint Inhibitors: Mechanisms, Diagnosis, and Management
Moturi, K. R., Sharma, H., & Hashemi‐Sadraei, N. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010414 · Cited by 18 · see citing works
Eijgelsheim, M., & Sprangers, B. (2020) · Kidney360 · doi:10.34067/kid.0001192019 · Cited by 17 · see citing works
Management of Drug-Associated Acute Interstitial Nephritis
Barreto, E. F., & Rule, A. D. (2020) · Kidney360 · doi:10.34067/kid.0000042019 · Cited by 16 · see citing works
Perazella, M. A., & Sprangers, B. (2021) · Clinical Kidney Journal · doi:10.1093/ckj/sfab052 · Cited by 16 · see citing works
Self-citationThe role of kidney biopsy in immune checkpoint inhibitor nephrotoxicity
Moss, E. M., & Perazella, M. A. (2022) · Frontiers in Medicine · doi:10.3389/fmed.2022.964335 · Cited by 16 · see citing works
Self-citationLei, R., Vu, B. V., Kourentzi, K. D., Soomro, S., Danthanarayana, A. N., Brgoch, J., Nadimpalli, S., Petri, M., Mohan, C., & Willson, R. C. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1044743 · Cited by 16 · see citing works
Seethapathy, H., Mistry, K., & Sise, M. E. (2023) · Immunological Reviews · doi:10.1111/imr.13243 · Cited by 15 · see citing works
Longhitano, E., Muscolino, P., Re, C. L., Ferrara, S. A., Cernaro, V., Gembillo, G., Tessitore, D., Speranza, D., Figura, F., Santarpía, M., et al. (2023) · Cancers · doi:10.3390/cancers15061891 · Cited by 15 · see citing works
Ibrutinib-induced acute kidney injury via interstitial nephritis
Markóth, C., File, I., Szász, R., Bidiga, L., Balla, J., & Mátyus, J. (2021) · Renal Failure · doi:10.1080/0886022x.2021.1874985 · Cited by 15 · see citing works
Ichii, O., Hosotani, M., Masum, A., Horino, T., Otani, Y., Namba, T., Nakamura, T., Ali, E. Y. H., & Kon, Y. (2022) · PubMed Central · doi:10.1681/asn.2021040575 · Cited by 14 · see citing works
Al-Amodi, H. S. A. B., Abdelsattar, S., Kasemy, Z. A. A., Bedair, H. M., Elbarbary, H. S., & Kamel, H. F. M. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.751299 · Cited by 14 · see citing works
Immunotherapy-Related Acute Kidney Injury
Manohar, S., Jhaveri, K. D., & Perazella, M. A. (2021) · Advances in Chronic Kidney Disease · doi:10.1053/j.ackd.2021.07.006 · Cited by 14 · see citing works
Self-citationMuhammad, A., Zhang, Y., Huang, L., Yuan, Q., Wang, W., Pu, J., Lin, W., Tang, R., & Xiao, X. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae054 · Cited by 13 · see citing works
Valenzuela, L. M., Draibe, J. B., Bestard, O., Fulladosa, X., Gómez-Preciado, F., Antón-Pàmpols, P., Nadal, E., Jové, M., Cruzado, J. M., & Torrás, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10132986 · Cited by 13 · see citing works
Şahutoğlu, T., & Perazella, M. A. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.03.050 · Cited by 15 · see citing works
Self-citationAcute interstitial nephritis: aetiology and management
Schurder, J., Buob, D., Perrin, P., Thervet, E., Karras, A., & Hertig, A. (2021) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfz262 · Cited by 12 · see citing works
Shariat‐Madar, Z., & Mahdi, F. (2025) · Molecules · doi:10.3390/molecules30224448 · Cited by 13 · see citing works
Nie, Q., Zhang, B., Li, R., Yang, Y., Ren, J., Qiu, L., Lu, Y., Zhu, L., Shen, H.-Y., Liu, Y., et al. (2023) · Microchimica Acta · doi:10.1007/s00604-023-06049-7 · Cited by 11 · see citing works
Kidney Biopsy in Patients with Cancer along the Last Decade: A Multicenter Study
Bolufer, M., García-Carro, C., Blasco, M., Quintana, L. F., Shabaka, A., Rabasco, C., Draibe, J. B., Merino, A., Melero, M. R., Alonso, F., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11102915 · Cited by 11 · see citing works
Biomarkers for Early Diagnosis of AKI: Could It Backfire?
Granado, R. C., Macedo, E. M., & Chavez-Iñiguez, J. S. (2022) · Kidney360 · doi:10.34067/kid.0001012022 · Cited by 11 · see citing works
Kommer, A., Stortz, M., Kraus, D., & Weinmann‐Menke, J. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14093231 · Cited by 10 · see citing works
Tumour necrosis factor‐alpha at the intersection of renal epithelial and immune cell function
Hubbi, S., Hao, S., Epps, J., & Ferreri, N. R. (2025) · The Journal of Physiology · doi:10.1113/jp286756 · Cited by 9 · see citing works
Medeiros, T., Alves, L. S., Cabral‐Castro, M. J., Silva, A. R. O., Xavier, A. R., Burger, D. E., Almeida, J. R., & Silva, A. A. (2022) · Diagnostics · doi:10.3390/diagnostics12112600 · Cited by 9 · see citing works
The development of lateral flow devices for urinary biomarkers to assess kidney health
Souza, S. D., Obeid, W., Hernandez, J., Hu, D. G., Wen, Y., Moledina, D. G., Albert, A., Gregg, A., Wheeler, A., Thiessen‐Philbrook, H., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-59104-5 · Cited by 9 · see citing works
Self-citationNovel Biomarkers and Imaging Tests for Acute Kidney Injury Diagnosis in Patients with Cancer
Mistry, K., Sadarangani, S. S., Moreno, D., Mejia, S. M., Moledina, D. G., & Sise, M. E. (2024) · Kidney360 · doi:10.34067/kid.0000000660 · Cited by 8 · see citing works
Self-citationThe renal damage and mechanisms relevant to antitumoral drugs
Tang, J., Yang, N., Pan, S., Ren, P., Chen, M., Jin, J., He, Q., & Zeng, Y. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1331671 · Cited by 8 · see citing works
Tascón, J., Casanova, A. G., Vicente-Vicente, L., Prieto, M., & Morales, A. I. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118430 · Cited by 7 · see citing works
Label-free microfiber biosensor for ultrahigh sensitivity detection of TNF-α protein
Zhang, Y., Jing, W., Zhang, Y., Qiu, S., Wang, W., Guo, Y., Han, Y., Zu, L., Jiang, L., Yuan, J., et al. (2025) · Optics Express · doi:10.1364/oe.551652 · Cited by 7 · see citing works
Genome-Wide Association Study in Acute Tubulointerstitial Nephritis
Zhou, S., Su, T., Xie, J., Xie, Q., Wang, L., Hu, Y., Chen, G., Jia, Y., Huang, J., Li, G., et al. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000091 · Cited by 7 · see citing works
Are biomarkers in acute kidney injury ready for prime time? The time is right for a second look
Parikh, C. R., & Coca, S. G. (2024) · Kidney International · doi:10.1016/j.kint.2024.01.018 · Cited by 7 · see citing works
Self-citationUrine testing to differentiate glomerular from tubulointerstitial diseases on kidney biopsy
Tran, A. C., Melchinger, H. C., Weinstein, J. N., Shaw, M. M., Kent, C., Perazella, M. A., Wilson, F. P., Parikh, C. R., & Moledina, D. G. (2022) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2022.e00271 · Cited by 7 · see citing works
Self-citationImmune-mediated Tubule Atrophy Promotes Acute Kidney Injury to Chronic Kidney Disease TransitionPreprint
Xu, L., Guo, J.-K., Moledina, D. G., & Cantley, L. G. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.06.01.494328 · Cited by 7 · see citing works
Self-citationRole of Mast Cells and Their Mediators in Chronic Kidney Diseases
Tziastoudi, M., Cholevas, C., Eleftheriadis, T., Stefanidis, I., & Theoharides, T. C. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26209981 · Cited by 6 · see citing works
Youssef, N., Habeeb, M., Chen, H., Alhamal, Z., Mamlouk, O., Lin, H. Y., Page, V. D., Tchakarov, A. S., Basu, S., Diab, A. K., et al. (2025) · Kidney International Reports · doi:10.1016/j.ekir.2025.10.018 · Cited by 6 · see citing works
Self-citationChavez, C. C. N., Bermejo, S., Narvaez, V. D. C., Refai, O. A., Sohi, G. K., Giesen, C. D., Kottschade, L. A., Markovic, S. N., Leung, N., Lieske, J. C., et al. (2026) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfag016 · Cited by 6 · see citing works
Acute kidney injury subphenotyping and personalized medicine
Meersch, M., Mayerhöfer, T., & Joannidis, M. (2024) · Current Opinion in Critical Care · doi:10.1097/mcc.0000000000001212 · Cited by 6 · see citing works
A mini review: Role of novel biomarker for kidney disease of future study
Mitra, P., Jana, S., & Roy, S. (2025) · Advances in Biomarker Sciences and Technology · doi:10.1016/j.abst.2025.02.002 · Cited by 6 · see citing works
Oya, Y., Futami, H., Nakazawa, T., Ishijima, K., Umemiya, K., Takizawa, F., Imai, N., Kitamura, H., & Matsumura, R. (2021) · Journal of Medical Case Reports · doi:10.1186/s13256-021-02909-z · Cited by 6 · see citing works
Chow, P., & Kuo, H. (2022) · International Urology and Nephrology · doi:10.1007/s11255-022-03265-7 · Cited by 6 · see citing works
Immune checkpoint inhibitors and kidney disease
Wang, Q., Moledina, D. G., & Sise, M. E. (2022) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0000000000000805 · Cited by 6 · see citing works
Self-citationBiomarkers in pursuit of precision medicine for acute kidney injury: hard to get rid of customs
Lin, K.-M., Su, C.-C., Chen, J., Pan, S., Chuang, M., Lin, C., Wu, C., Pan, H., & Wu, V. (2024) · Kidney Research and Clinical Practice · doi:10.23876/j.krcp.23.284 · Cited by 5 · see citing works
10 tips on how to use dynamic risk assessment and alerts for AKI
Quickfall, D., La, A. M., & Koyner, J. L. (2024) · Clinical Kidney Journal · doi:10.1093/ckj/sfae325 · Cited by 5 · see citing works
Guan, C.-J., Chen, R., & Wang, Y. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2486565 · Cited by 5 · see citing works
Urinary TNF-α as a potential biomarker for chronic primary low back pain
Gevers‐Montoro, C., Puente-Tobares, M., Monréal, A., Conesa‐Buendía, F. M., Piché, M., & Mues, A. O.-D. (2023) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2023.1207666 · Cited by 6 · see citing works
Acute Kidney Injury with Immune Checkpoint Inhibitors
Carlos, C. A., & Hsu, R. K. (2019) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.12621019 · Cited by 5 · see citing works
Moledina, D. G., Shelton, K., Menez, S. P., Aklilu, A. M., Yamamoto, Y., Kadhim, B. A., Shaw, M. M., Kent, C., Makhijani, A., Hu, D. G., et al. (2024) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000556 · Cited by 4 · see citing works
Self-citationCasanova, A. G., Tascón, J., del Barco, E., Olivares, A., Carretero, T., Villaizan, M. H., Sánchez-Sierra, A. C., Villanueva-Sánchez, E., Pescador, M., Prieto, M., et al. (2025) · American Journal of Nephrology · doi:10.1159/000548773 · Cited by 3 · see citing works
What new renal biomarkers tell us about renal physiology
Meersch, M., Joannidis, M., de Rosa, S. S., Endre, Z. H., & Ostermann, M. (2026) · Annals of Intensive Care · doi:10.1016/j.aicoj.2025.100017 · Cited by 3 · see citing works
- Authors
- Moledina, D. G., Wilson, F. P., Pober, J. S., Perazella, M. A., Singh, N., Luciano, R. L., Obeid, W., Lin, H., Kuperman, M., Moeckel, G. W., Kashgarian, M., Cantley, L. G., & Parikh, C. R.
- Affiliations
- Section of Nephrology, Department of Internal Medicine,
- Yale University (US)
- Johns Hopkins University (US)
- Arkana Laboratories (US)
- Department of Pathology, and
- Corresponding author
- Parikh, Chirag R.
- ORCID
- Venue
- JCI Insight
- Published
- 2019-05-16
- Volume
- 4
- Issue
- 10
- ISSN
- 2379-3708 (ISSN-L)
- PMC
- PMC6542610
- OpenAlex
- W2945207519
- Cited by
- 154
- References
- 33
- Citations by year
- 2026: 16 · 2025: 27 · 2024: 23 · 2023: 20 · 2022: 26 · 2021: 22 · 2020: 12 · 2019: 8
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- JCI Insight (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (K23DK117065, T32DK007276, K23DK097201, K24DK090203, UG3DK114866, R01DK113191, P30DK079310)
- American Heart Association (18CDA34060118)
- Robert E. Leet and Clara Guthrie Patterson Trust
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Transplantation › Renal Transplantation Outcomes and Treatments
- Keywords
- acute interstitial nephritis, urinary biomarkers, TNF-α, IL-9, acute kidney disease, T cell cytokines, diagnostic biomarkers, renal biopsy, eosinophils, pyuria, proteinuria, acute tubular injury, glomerular disease, diabetic nephropathy, cytokine panel, differential diagnosis of acute kidney injury, T cell-mediated inflammation
- MeSH terms
- Acute Disease, Aged, Biopsy, Eosinophils, Female, Humans, Kidney, Male, Middle Aged, Nephritis, Interstitial, Tumor Necrosis Factor-alpha, Biomarkers, Cytokines, Interleukin-9, Acute Kidney Injury
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
