The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Studies on Phenolic Steroids in Human Subjects. II. The Metabolic Fate and Hepato-Biliary-Enteric Circulation of C14-Estrone and C14-Estradiol in Women1
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METHODS AND MATERIALSOne to two /sc. of 16-C1'-estrone (B1) or 16-CM-estra- diol-17,B (E2) 2 (both 1Elc.per 370 pg.) were injected 2C4.-estrone and C"-estradiol were purchased from Charles E. Frosst & Co., Montreal, Canada.When the preparations were chromatographed in our laboratory, 1266
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“estrogens seem to undergo higher biliary excretion than other steroids, but also higher reabsorption leading to low fecal excretion [194,206].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [206]
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Cites
THE PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF HYDROCORTISONE IN MAN
Peterson, R. E., Wyngaarden, J. Β., Guerra, S., Brodie, B. B., & Bunim, J. J. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103233 · Cited by 372
THE PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF HYDROCORTISONE IN MAN
Peterson, R. E., & Wyngaarden, J. Β. (1955) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1955.tb42479.x · Cited by 94
THE FATE OF HYDROCORTISONE-4-C14 IN MAN 1
HELLMAN, L., Bradlow, H. L., Adesman, J., Fukushima, D. K., Kulp, J. L., & Gallagher, T. F. (1954) · Journal of Clinical Investigation · doi:10.1172/jci102984 · Cited by 92
METABOLISM OF 4-C14-TESTOSTERONE IN HUMAN SUBJECTS. I. DISTRIBUTION IN BILE, BLOOD, FECES AND URINE
Sandberg, A. A., & Slaunwhite, W. R. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103389 · Cited by 90
METABOLISM OF 4-C14-CORTISOL IN MAN: BODY DISTRIBUTION AND RATES OF CONJUGATION*†
Migeon, C. J., Sandberg, A. A., DECKER, H. A., SMITH, D. F., PAUL, A. C., & SAMUEL, L. T. (1956) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-16-9-1137b · Cited by 88
The isolation of 16-epioestriol from the urine of pregnant women
Marrian, G. F., & Bauld, W. S. (1955) · Biochemical Journal · doi:10.1042/bj0590136 · Cited by 77
EXCRETION OF ESTROGEN METABOLITES BY HUMANS
Beer, C. T., & Gallagher, T. F. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70972-1 · Cited by 73
Observations concerning the metabolism of estrogens in women
Smith, G. V. S., & Smith, O. W. (1938) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(38)90572-1 · Cited by 70
Studies on phenolic steroids in human subjects
Slaunwhite, W. R., & Sandberg, A. A. (1956) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(56)90065-0 · Cited by 63
THE FATE OF TESTOSTERONE INFUSED INTRAVENOUSLY IN MAN
Fukushima, D. K., Bradlow, H. L., Dobriner, K., & Gallagher, T. F. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50857-2 · Cited by 55
Research works printed but not linked: 11
- Pincus, G., and Pearlman, W. H., Metabolism of es- trone in men and non-pregnant women. Endo- crinology, 1942, 31, 507.
- Heard, R. D. H., and Hoffman, M. M., Steroids IV. The fate in man of injected a-estradiol. J. Biol. Chem., 1941, 141, 329.
- Pearlman, W. H., Paschkis, K. E., Rakoff, A. E., Cantarow, A., Walking, A. A., and Hansen, L. P., A note on the biliary excretion of endogenous estrogens. Endocrinology, 1945, 36, 284.
- Rakoff, A. E., Cantarow, A., Paschkis, K. E., Han- sen, L. P., and Walking, A. A., Removal of exogenous estrogens from the circulation. Endo- crinology, 1944, 34, 370.
- Hellman, L., Bradlow, H. L., Adesman, J., Fuku- shima, D. K., Kulp, J. L., and Gallagher, T. F., The fate of hydrocortisone-4-C' in man. J. Clin. Invest., 1954, 33, 1106.
- Bradlow, H. L., Hellman, L., and Gallagher, T. F., Metabolism of 11-hydroxy-A'-androstene-3,17-dione- 4-C14. Federation Proc., 1956, 15, 223.
- Rubin, B. L., Dorfman, R. I., and Miller, M., Andro- gen excretion in human bile. Endocrinology, 1952, 51, 463.
- Stimmel, B. F., Simultaneous biliary and urinary exogenous estrogen excretion studies in man. Federation Proc., 1951, 10, 254.
- Stimmel, B. F., Reduction of radioactive estrone to estradiol by human feces. Federation Proc., 1954, 13, 305.
- Szego, C. M., The influence of the liver upon estro- gen-protein binding in vitro. Endocrinology, 1953, 52, 669.
- Sandberg, A. A., and Slaunwhite, W. R., Jr., Biliary excretion and protein binding of radioactive ster- oids in human subjects: Their possible relation- ship. J. Clin. Endocrinol. & Metab., 1956, 16, 923.
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Intestinal flora in health and disease
Simon, G. L., & Gorbach, S. L. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90606-1 · Cited by 818
Plottel, C. S., & Blaser, M. J. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.003 · Cited by 743
Roberts, M. S., Magnusson, B. M., Burczynski, F. J., & Weiß, M. (2002) · Clinical Pharmacokinetics · doi:10.2165/00003088-200241100-00005 · Cited by 684
The Intestinal Microbiome and Estrogen Receptor–Positive Female Breast Cancer
Kwa, M. J., Plottel, C. S., Blaser, M. J., & Adams, S. (2016) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djw029 · Cited by 547
Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450
Metadata
- Authors
- Sandberg, A. A., & Slaunwhite, W. R.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1957-08-01
- Volume
- 36
- Issue
- 8
- Pages
- 1266-1278
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1072719
- OpenAlex
- W2145281171
- Cited by
- 184
- References
- 41
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- phenolic steroids, estrone, estradiol, radiolabeled steroids, metabolic fate, hepatic metabolism, biliary excretion, intestinal circulation, women, steroid metabolism
- MeSH terms
- Estradiol, Estrogens, Estrone, Female, Humans, Steroids, Gastrointestinal Tract, Lipid Metabolism
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