Cited by 184Estrogen and related hormone effectsSteroid Chemistry and BiochemistryPharmacogenetics and Drug Metabolism

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Studies on Phenolic Steroids in Human Subjects. II. The Metabolic Fate and Hepato-Biliary-Enteric Circulation of C14-Estrone and C14-Estradiol in Women1

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Sandberg, Avery A., Slaunwhite, W. Roy·1957·Journal of Clinical Investigation

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Abstract

METHODS AND MATERIALSOne to two /sc. of 16-C1'-estrone (B1) or 16-CM-estra- diol-17,B (E2) 2 (both 1Elc.per 370 pg.) were injected 2C4.-estrone and C"-estradiol were purchased from Charles E. Frosst & Co., Montreal, Canada.When the preparations were chromatographed in our laboratory, 1266

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THE PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF HYDROCORTISONE IN MAN
Peterson, R. E., Wyngaarden, J. Β., Guerra, S., Brodie, B. B., & Bunim, J. J. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103233 · Cited by 372
THE PHYSIOLOGICAL DISPOSITION AND METABOLIC FATE OF HYDROCORTISONE IN MAN
Peterson, R. E., & Wyngaarden, J. Β. (1955) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1955.tb42479.x · Cited by 94
THE FATE OF HYDROCORTISONE-4-C14 IN MAN 1
HELLMAN, L., Bradlow, H. L., Adesman, J., Fukushima, D. K., Kulp, J. L., & Gallagher, T. F. (1954) · Journal of Clinical Investigation · doi:10.1172/jci102984 · Cited by 92
METABOLISM OF 4-C14-TESTOSTERONE IN HUMAN SUBJECTS. I. DISTRIBUTION IN BILE, BLOOD, FECES AND URINE
Sandberg, A. A., & Slaunwhite, W. R. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103389 · Cited by 90
METABOLISM OF 4-C14-CORTISOL IN MAN: BODY DISTRIBUTION AND RATES OF CONJUGATION*†
Migeon, C. J., Sandberg, A. A., DECKER, H. A., SMITH, D. F., PAUL, A. C., & SAMUEL, L. T. (1956) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-16-9-1137b · Cited by 88
The isolation of 16-epioestriol from the urine of pregnant women
Marrian, G. F., & Bauld, W. S. (1955) · Biochemical Journal · doi:10.1042/bj0590136 · Cited by 77
EXCRETION OF ESTROGEN METABOLITES BY HUMANS
Beer, C. T., & Gallagher, T. F. (1955) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)70972-1 · Cited by 73
Observations concerning the metabolism of estrogens in women
Smith, G. V. S., & Smith, O. W. (1938) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(38)90572-1 · Cited by 70
Studies on phenolic steroids in human subjects
Slaunwhite, W. R., & Sandberg, A. A. (1956) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(56)90065-0 · Cited by 63
THE FATE OF TESTOSTERONE INFUSED INTRAVENOUSLY IN MAN
Fukushima, D. K., Bradlow, H. L., Dobriner, K., & Gallagher, T. F. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50857-2 · Cited by 55

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IN VITRO INTERCONVERSION OF 16-C14-ESTRONE AND 16-C14-ESTRADIOL-17β BY ERYTHROCYTES FROM NORMAL SUBJECTS AND FROM SUBJECTS WITH A DEFICIENCY OF RED CELL GLUCOSE-6-PHOSPHATE DEHYDROGENASE ACTIVITY*
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Authors: Sandberg, A. A., & Slaunwhite, W. R.
Affiliations: Roswell Park Comprehensive Cancer Center (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1957-08-01
Volume: 36
Issue: 8
Pages: 1266-1278
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci103524
PMC: PMC1072719
OpenAlex: W2145281171
Cited by: 184
References: 41
Citations by year: 2026: 6 · 2025: 4 · 2024: 4 · 2023: 6 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 1 · 2016: 1 · 2014: 1 · 2013: 1
FWCI: 5.64
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords: phenolic steroids, estrone, estradiol, radiolabeled steroids, metabolic fate, hepatic metabolism, biliary excretion, intestinal circulation, women, steroid metabolism
MeSH terms: Estradiol, Estrogens, Estrone, Female, Humans, Steroids, Gastrointestinal Tract, Lipid Metabolism

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Studies on Phenolic Steroids in Human Subjects. II. The Metabolic Fate and Hepato-Biliary-Enteric Circulation of C14-Estrone and C14-Estradiol in Women1

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