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RELATIONSHIPS OF PYRUVATE AND LACTATE DURING ANAEROBIC METABOLISM. I. EFFECTS OF INFUSION OF PYRUVATE OR GLUCOSE AND OF HYPERVENTILATION1
Open accessAbstract
When the supply of oxygen to the interior of living cells is reduced to a rate insufficient for their current metabolic needs for oxygen, then various cellular oxidation-reduction systems must shift toward a more reduced state.Thus, as the oxy- gen tension falls the "oxidation potential" ("Eh") decreases (1, 2), (the rate of decrease being a complex and variable function of Po2 and also of the rate of energy utilization), and the various redox systems shift toward their reduced forms in a sequence determined by their inherent redox characteristics (1), cytochrome oxidase, the cyto- chromes and their dependent systems, flavopro- teins and diphosphopyridine nucleotide (DPN).
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Cited by
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
WEIL, M. H., & AFIFI, A. A. (1970) · Circulation · doi:10.1161/01.cir.41.6.989 · Cited by 709
THE DAMAGE CONTROL SEQUENCE AND UNDERLYING LOGIC
Rotondo, M. F., & Zonies, D. H. (1997) · Surgical Clinics of North America · doi:10.1016/s0039-6109(05)70582-x · Cited by 441
The anaerobic threshold: 50+ years of controversy
Poole, D. C., Rossiter, H. B., Brooks, G. A., & Gladden, L. B. (2021) · The Journal of Physiology · doi:10.1113/jp279963 · Cited by 312
D-lactic acidosis – case report and review of the literature
Fabian, E., Kramer, L., Siebert, F., Högenauer, C., Raggam, R., Wenzl, H., & Krejs, G. (2016) · Zeitschrift für Gastroenterologie · doi:10.1055/s-0042-117647 · Cited by 38
Metadata
- Authors
- Huckabee, W. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1958-02-01
- Volume
- 37
- Issue
- 2
- Pages
- 244-254
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2120061499
- Cited by
- 669
- References
- 0
- FWCI
- 9.15
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: RELATIONSHIPS OF PYRUVATE AND LACTATE DURING ANAEROBIC METABOLISM. I. EFFECTS OF INFUSION OF PYRUVATE OR GLUCOSE AND OF HYPERVENTILATION1. https://app.cochat.ai/papers/10.1172/jci103603
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- Huckabee, W. E. (1958). RELATIONSHIPS OF PYRUVATE AND LACTATE DURING ANAEROBIC METABOLISM. I. EFFECTS OF INFUSION OF PYRUVATE OR GLUCOSE AND OF HYPERVENTILATION1. Journal of Clinical Investigation. https://doi.org/10.1172/jci103603
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