Pantothenic Acid Deficiency in Man1
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Vitamin B5 deficiency experimentally induced in humans causes headache, fatigue, insomnia, and excessive fatigue after daily walk, which decrease and disappear after 4 weeks of supplementation with 4 g pantothenic acid daily.
“After approximately 6 weeks, subjects complained of headache, fatigue, insomnia, and they reported excessive fatigue after their daily walk; symptoms decreased then disappeared after 4 weeks of supplementation with 4 g pantothenic acid daily [103].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [103]
Pantothenic acid deficiency results in neurological dysfunction, including acute encephalopathy in dogs and personality changes in humans.
“Deficiency in pantothenic acid (vitamin B5) results in neurological dysfunction. Dogs treated with an antagonist of vitamin B5 that induces a deficiency of pantothenic acid developed an acute encephalopathy [144].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [103]
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Sachs, M., Asskali, F., Lanaras, C., Forster, H., & Bockhorn, H. (1990) · Zeitschrift für Ernährungswissenschaft · doi:10.1007/bf02023084 · Cited by 2 · see citing works
Water-soluble vitamins and ageing
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The Interaction between the Gastrointestinal Tract and Nutrient Intake
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Pantothenic Acid and Coenzyme A
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Effects of Pantothenate Deficiency on Steroid Hormone Secretion in Rats
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Effects of Pantothenate Deficiency on Steroid Hormone Secretion in Rats
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Besin Takviyelerine Bilimsel Bakış
Fidancı, A., Akpınar, B., Kutsal, E., Bal, E., Yıldırım, E., Duman, E. U., Ergin, E., Paksoy, F. N., Derici, G. E., Ergene, G., et al. (2022) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.1062
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Exploring the link between water-soluble vitamins and aging-associated immune system status
Schmieder, H., Detert, K., Leischner, C., Venturelli, S., & Burkard, M. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1771591
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Inherited disorders of vitamins and cofactors
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- Authors
- Hodges, R. E., Ohlson, M. A., & Bean, W. B.
- Affiliations
- University of Iowa (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1958-11-01
- Volume
- 37
- Issue
- 11
- Pages
- 1642-1657
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC1062846
- OpenAlex
- W2004485450
- Cited by
- 91
- References
- 39
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2012: 2
- FWCI
- 2.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- pantothenic acid deficiency, pantothenic acid, vitamin deficiency, human nutrition
- MeSH terms
- Humans, Male, Pantothenic Acid
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