Cited by 91Folate and B Vitamins ResearchNeurological diseases and metabolismMetabolism and Genetic Disorders

Pantothenic Acid Deficiency in Man1

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Hodges, Robert E., Ohlson, Margaret A., Bean, William B.·1958·Journal of Clinical Investigation

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Crossref · 10.1172/jci103756

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  • Vitamin B5 deficiency experimentally induced in humans causes headache, fatigue, insomnia, and excessive fatigue after daily walk, which decrease and disappear after 4 weeks of supplementation with 4 g pantothenic acid daily.

    “After approximately 6 weeks, subjects complained of headache, fatigue, insomnia, and they reported excessive fatigue after their daily walk; symptoms decreased then disappeared after 4 weeks of supplementation with 4 g pantothenic acid daily [103].”
  • Pantothenic acid deficiency results in neurological dysfunction, including acute encephalopathy in dogs and personality changes in humans.

    “Deficiency in pantothenic acid (vitamin B5) results in neurological dysfunction. Dogs treated with an antagonist of vitamin B5 that induces a deficiency of pantothenic acid developed an acute encephalopathy [144].”

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Authors
Hodges, R. E., Ohlson, M. A., & Bean, W. B.
Affiliations
University of Iowa (US)
Venue
Journal of Clinical Investigation
Published
1958-11-01
Volume
37
Issue
11
Pages
1642-1657
ISSN
0021-9738 (ISSN-L)
OpenAlex
W2004485450
Cited by
91
References
39
Citations by year
2026: 5 · 2025: 2 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2012: 2
FWCI
2.16
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Eli Lilly and Company
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
Keywords
pantothenic acid deficiency, pantothenic acid, vitamin deficiency, human nutrition
MeSH terms
Humans, Male, Pantothenic Acid

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