Kinetics of triglyceride turnover of very low density lipoproteins of human plasma

Reaven, G M; Hill, D B; Gross, R C; Farquhar, J W

doi:10.1172/jci105290

Cited by 221Lipid metabolism and disordersCholesterol and Lipid MetabolismLipoproteins and Cardiovascular Health

Kinetics of triglyceride turnover of very low density lipoproteins of human plasma

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Reaven, G M, Hill, D B, Gross, R C, Farquhar, J W·1965·Journal of Clinical Investigation

DOI 10.1172/jci105290PMC PMC289683

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Abstract

Ahrens and co-workers (1) have collated and extended prior observations (2-7) that high car- bohydrate, low fat diets may cause hypertriglyceridemia in certain subjects.They termed this phenomenon "carbohydrate-induced lipemia" (1).Despite uncertainties concerning the degree or duration of plasma triglyceride rise needed to merit this appellation, this general response to a high carbohydrate diet is frequently observed in patients with evidence for accelerated atherogenesis (1, 8-10).Furthermore, elevated plasma triglycerides are common in patients with "pre- mature" arteriosclerotic heart disease on ad libitum diets (11-16).Consequently, it becomes im- portant to define the factors controlling plasma triglyceride concentration in man.It can be assumed that changes in concentra- tion of water soluble macromolecules confined to the plasma space, such as lipoproteins, result from variations in rates of entry into and re- moval from plasma, or both.Hypertriglyceridemia in patients with "fat-induced lipemia," another and a relatively uncommon syndrome (1,

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Plasma triglyceride levels range from 0.33 to 120 mmol/L, reflecting variability in the rates of secretion and clearance of triglyceride and apoB in VLDL and chylomicrons.
“Plasma TG levels range from 0.33 to 120 mmol/L (30 to 10 000 mg/dL)13,17 (Figure 6), reflecting variability in the rates of secretion and clearance of TG and apoB in VLDL and chylomicrons.61,77”
From Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society (2021) · cites this paper as [77]

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Authors: Reaven, G. M., Hill, D. B., Gross, R. C., & Farquhar, J. W.
Affiliations: Stanford Medicine (US)
United States Public Health Service (US)
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1965-11-01
Volume: 44
Issue: 11
Pages: 1826-1833
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci105290
PMC: PMC289683
OpenAlex: W1996392591
Cited by: 221
References: 32
Citations by year: 2026: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2017: 1 · 2014: 1
FWCI: 13.07
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords: VLDL, triglyceride turnover, hypertriglyceridemia, lipoprotein kinetics, atherogenesis, arteriosclerotic heart disease
MeSH terms: Adult, Female, Glycerides, Humans, Kinetics, Lipoproteins, Male, Middle Aged, Models, Theoretical, Lipid Metabolism

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Kinetics of triglyceride turnover of very low density lipoproteins of human plasma

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