The DOI matches its Crossref record; 37 of the 38 references it cites were found in a registry or an index.
17-Hydroxylation deficiency in man
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The initial description of 17␣-hydroxylase deficiency was a case in which both 17␣-hydroxylase and 17,20lyase products were absent (261).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [261]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“As a result, affected females are phenotypically normal but fail to undergo adrenarche and puberty (261),”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [261]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The classical presentation is that of a teenage female with sexual infantilism and hypertension (261,264).”
From The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders (2011) · cites this paper as [261]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Practical Physiological Chemistry
(1938) · JAMA · doi:10.1001/jama.1938.02790100062037 · Cited by 1,364
On the Enzymatic Determination of Blood Glucose
Raabo, B. E., & Terkildsen, T. C. (1960) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365516009065404 · Cited by 925
PRACTICAL PHYSIOLOGICAL CHEMISTRY
HAWK, P. B., Oser, B. L., & SUMMERSON, W. H. (1955) · The American Journal of the Medical Sciences · doi:10.1097/00000441-195507000-00025 · Cited by 908
THE DETERMINATION OF 17, 21-DIHYDROXY-20-KETOSTEROIDS IN URINE AND PLASMA
SILBER, R. H., & Porter, C. C. (1954) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)65419-5 · Cited by 779
STEELMAN, S. L., & Pohley, F. M. (1953) · Endocrinology · doi:10.1210/endo-53-6-604 · Cited by 698
Double Isotope Derivative Assay of Aldosterone in Biological Extracts
Kliman, B., & Peterson, R. E. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76855-0 · Cited by 592
Cotlove, E., Trantham, H. V., & Bowman, R. L. (1958) · PubMed · Cited by 427
NEW PROCEDURES FOR MEASUREMENT OF HUMAN PLASMA ANGIOTENSIN AND RENIN ACTIVITY LEVELS.
Boucher, R., Veyrat, R., de Champlain, J., & Genest, J. (1964) · PubMed Central · Cited by 401
AN IMMUNOCHEMICAL ASSAY OF TOTAL EXTRACTABLE INSULIN IN MAN *
Grodsky, G. M., & Forsham, P. H. (1960) · Journal of Clinical Investigation · doi:10.1172/jci104122 · Cited by 350
The adrenogenital syndrome with deficiency of 3β-hydroxysteroid dehydrogenase
Bongiovanni, A. M. (1962) · Journal of Clinical Investigation · doi:10.1172/jci104666 · Cited by 304
Research works printed but not linked: 3
- [12]12. Riondel, A., J. F. Tait, S. A. S. Tait, M. Gut, and B. Little.' Estimation of progesterone in human peripheral blood using 'S-thiosemicarbazide. J. clin. Endocr. 1965, 25, 229.
- [14]14. Horton, R. Estimation of androstenedione in human peripheral blood with 'S-thiosemicarbazide. J. clin. Endocr. 1965, 25, 1237.
- [31]31. Biglieri, E. G., P. E. Slaton, Jr., W. S. Silen, M. Galante, and P. H. Forsham. Postoperative stud- ies of adrenal function in primary aldosteronism. J. clin. Endocr. 1966, 26, 553.
Cited by
Sorted by citations
The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders
Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458
Congenital Adrenal Hyperplasia
Speiser, P., & White, P. C. (1987) · New England Journal of Medicine · doi:10.1056/nejm198711263172211 · Cited by 1,420
Congenital adrenal hyperplasia
Speiser, P. W., & White, P. C. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021561 · Cited by 1,405
Congenital adrenal hyperplasia
El-Maouche, D., Arlt, W., & Merke, D. P. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31431-9 · Cited by 669
Familial Incomplete Male Pseudohermaphroditism, Type 2
Walsh, P. C., Madden, J. D., Harrod, M. J., Goldstein, J. L., MacDonald, P. C., & Wilson, J. D. (1974) · New England Journal of Medicine · doi:10.1056/nejm197410312911806 · Cited by 621
Metadata
- Authors
- Biglieri, E. G., Herron, M. A., & Brust, N.
- Affiliations
- San Francisco General Hospital (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1966-12-01
- Volume
- 45
- Issue
- 12
- Pages
- 1946-1954
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC292880
- OpenAlex
- W2025408018
- Semantic Scholar
- 4321404e8c055df66091f50f82aa9945d6208f8d
- Cited by
- 561
- References
- 38
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 5 · 2023: 16 · 2022: 14 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 5 · 2017: 12 · 2016: 7 · 2015: 15 · 2014: 13 · 2013: 14 · 2012: 10
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cisco Systems
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- congenital adrenal hyperplasia, steroidogenesis, adrenal cortex, 17-hydroxyprogesterone
- MeSH terms
- Adrenal Glands, Adrenocorticotropic Hormone, Adult, Corticosterone, Desoxycorticosterone, Diet, Sodium-Restricted, Female, Humans, Mixed Function Oxygenases, Hydroxyprogesterones, Metabolism, Inborn Errors, Metyrapone, Natriuresis, Potassium, Progesterone
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
