The DOI matches its Crossref record.
Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*
Open accessAbstract
Inhalation of aerosols of citric acid, histamine phosphate, or carbon dust, or air cooled to - 20 degrees C or rapid respiratory maneuvers (inspiration or expiration) results in an increase in airway resistance in some patients with asthma or bronchitis. It has been shown previously in animals that stimulation of cough receptors results in bronchoconstriction through efferent cholinergic pathways. In the patients studied, the administration of atropine sulfate, which would block such pathways, abolished the bronchoconstrictor effects of all the stimuli except large doses of histamine, which may exert a direct effect on airway smooth muscle. These data suggest that sensitized cough receptors may be involved in triggering reflex airway constriction in such patients.
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Citations
Cited by
Orehek, J., Massari, J. P., Gayrard, P., Grimaud, C., & Charpin, J. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108281 · Cited by 296
Cigarette Smoke Particle-Induced Lung Injury and Iron Homeostasis
Ghio, A. J., Pavlisko, E. N., Roggli, V. L., Todd, N. W., & Sangani, R. G. (2022) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s337354 · Cited by 19
Metadata
- Authors
- Simonsson, B. G., Jacobs, F. M., & Nadel, J. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1967-11-01
- Volume
- 46
- Issue
- 11
- Pages
- 1812-1818
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2135291856
- Cited by
- 367
- References
- 0
- FWCI
- 17.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*. https://app.cochat.ai/papers/10.1172/jci105671
- The paper
- Simonsson, B. G., Jacobs, F. M., & Nadel, J. A. (1967). Role of Autonomic Nervous System and the Cough Reflex in the Increased Responsiveness of Airways in Patients with Obstructive Airway Disease*. Journal of Clinical Investigation. https://doi.org/10.1172/jci105671
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
