Plasma progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia
Open accessAbstract
Plasma 17-hydroxyprogesterone (17-OHP) concentrations in normal men averaged 0.094 mug/100 ml. Studies using suppressive doses of androgens and glucocorticoids showed that 90% of the 17-OHP originated from the Leydig cell. The 17-OHP production rate was 1.8 mg/24 hr. Plasma 17-OHP has a marked circadian variation, the 8 p.m. values being only 40% of the 8 a.m. values. Plasma luteinizing hormone measured in the same samples did not vary. The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. In children with congenital adrenal hyperplasia, plasma 17-OHP levels were 50-200 times those of normal men and plasma progesterone was increased 6- to 10-fold over normal men.
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Low levels of circulating progesterone are also detectable in men.
“Low levels of circulating progesterone are also detectable in men [334].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [334]
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- Authors
- Strott, C. A., Yoshimi, T., & Lipsett, M. B.
- Affiliations
- National Cancer Institute (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1969-05-01
- Volume
- 48
- Issue
- 5
- Pages
- 930-939
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC322302
- OpenAlex
- W2143971785
- Cited by
- 132
- References
- 20
- Citations by year
- 2025: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 1 · 2013: 1
- FWCI
- 3.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- plasma progesterone, 17-hydroxyprogesterone, congenital adrenal hyperplasia, Leydig cells, circadian variation, luteinizing hormone, ACTH, androgen deprivation therapy, glucocorticoid suppression, children
- MeSH terms
- Adolescent, Adrenocortical Hyperfunction, Adrenal Hyperplasia, Congenital, Adrenocorticotropic Hormone, Adult, Child, Circadian Rhythm, Dexamethasone, Female, Fluoxymesterone, Chorionic Gonadotropin, Humans, Hydroxyprogesterones, Hyperplasia, Leydig Cells, Luteinizing Hormone, Male, Menstruation, Metabolic Clearance Rate, Middle Aged, Progesterone
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