The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
The role of glucocorticoids in the regulation of thyroid function in man
Open accessAbstract
The diurnal variation in thyroidal iodine release previously observed in euthyroid subjects appears to correlate with variations in serum immunoassayable thyrotropin (TSH). The hypothesis is advanced that this diurnal rhythm seems to be primarily regulated by a negative feedback action of circulating hydrocortisone. The administration of maintenance doses of hydrocortisone to patients with primary adrenal insufficiency and pharmacological doses to euthyroid subjects was accompanied by an acute suppression in both thyroidal iodine release and serum TSH values. An escape from glucocorticoid suppression was observed to occur in 2 or 3 days with the resumption of a near-normal thyroidal iodine release rate but was accompanied by a dampening or absence of the normal diurnal rhythm. Withdrawal of pharmacological doses of glucocorticoids in euthyroid subjects and maintenance doses in primary hypoadrenal patients was accompanied by transient stimulation of both serum TSH and thyroidal iodine release values. The study of a patient before and after cryohypophysectomy indicated that the rebound response in thyroid release after steroid withdrawal may be a useful testing procedure to indirectly assess the hypothalamicpituitary reserve capacity of TSH.
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“Hypothalamic TRH is also modulated by glucocorticoids, as high glucocorticoid levels suppress the pituitary response to TRH in man [69], while a postmortem study in human hypothalamus showed that glucocorticoid treatment is associated with downregulation of TR neurons in the human PVN [14].”
From An update on non-thyroidal illness syndrome (2021) · cites this paper as [69]
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Citations
Cites
Studies of Thyrotropin Physiology by Means of Radioimmunoassay
Odell, W. D., Wilber, J. F., & Utiger, R. D. (1967) · Elsevier eBooks · doi:10.1016/b978-1-4831-9826-2.50005-2 · Cited by 278
The effect of glucocorticoids on thyrotropin secretion
Wilber, J. F., & Utiger, R. D. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106176 · Cited by 269
Acute release of thyrotropin in the newborn
Fisher, D. A., & Odell, W. D. (1969) · Journal of Clinical Investigation · doi:10.1172/jci106132 · Cited by 229
Self-citationNugent, C. A., Mayes, D. M., & Morrett, S. (1966) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-26-10-1116 · Cited by 127
Effect of Exercise on Thyroxine Degradation in Athletes and Non-athletes
IRVINE, C. H. G. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-7-942 · Cited by 67
A CORRELATIVE STUDY OF ENDOCRINE RHYTHMS IN RATS
Retiene, K., Zimmerman, E., SCHINDLER, W. J., Neuenschwander, J. T. K., & LIPSCOMB, H. S. (1968) · European Journal of Endocrinology · doi:10.1530/acta.0.0570615 · Cited by 59
ACTH, cortisone and the metabolism of iodine.
Freinkel, N., & Ingbar, S. H. (1956) · PubMed · Cited by 50
Lemarchand-Béraud, T., & Vannotti, A. (1969) · European Journal of Endocrinology · doi:10.1530/acta.0.0600315 · Cited by 49
Circadian periodicity in thyroid stimulating hormone titer in the rat hypophysis and serum
Bakke, J. L., & Lawrence, N. L. (1965) · Metabolism · doi:10.1016/0026-0495(65)90013-2 · Cited by 48
A new method for the measurement of thyroidal iodine release in man
Nicoloff, J. T. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106410 · Cited by 47
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Association between thyroid function and serum cortisol in cortisol-producing adenoma patients
Cai, R., Zhou, W., Jiang, L., Jiang, Y., Su, T., Zhang, C., Zhou, W., Ning, G., & Wang, W. (2020) · Endocrine · doi:10.1007/s12020-020-02278-5 · Cited by 18
Approach to a low TSH level: patience is a virtue
Pantalone, K. M., & Nasr, C. (2010) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.77a.10056 · Cited by 16
Poorly controlled congenital hypothyroidism due to an underlying Allgrove syndrome
van Tellingen, V., Finken, M. J. J., Israëls, J., Hendriks, Y. M. C., Kamp, G. A., & van Santen, H. M. (2016) · Hormone Research in Paediatrics · doi:10.1159/000446604 · Cited by 5
Assessing Thyroid Function in Hospitalized Patients
LoPresti, J. S., & Patil, K. S. (2010) · Endocrine Updates · doi:10.1007/978-1-4419-1485-9_10 · Cited by 3
Metadata
- Authors
- Nicoloff, J. T., Fisher, D. A., & Appleman, M. D.
- Affiliations
- University of Southern California (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1970-10-01
- Volume
- 49
- Issue
- 10
- Pages
- 1922-1929
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC322682
- OpenAlex
- W2112972977
- Cited by
- 261
- References
- 14
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 10 · 2022: 7 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 7 · 2013: 4 · 2012: 4
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- glucocorticoids, cortisol, thyroid function, diurnal cycle, thyroid-stimulating hormone, negative feedback, Addison's disease, glucocorticoid withdrawal, hypothalamic-pituitary-thyroid axis
- MeSH terms
- Adrenal Gland Diseases, Circadian Rhythm, Feedback, Humans, Hydrocortisone, Iodine, Prednisolone, Thyroid Gland, Thyrotropin, Thyroxine-Binding Proteins
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