Cited by 18Adrenal and Paraganglionic TumorsAdrenal Hormones and DisordersPituitary Gland Disorders and Treatments

Association between thyroid function and serum cortisol in cortisol-producing adenoma patients

Cai, Rongrong, Zhou, Weiwei, Jiang, Lei, Jiang, Yiran, Su, Tingwei, Zhang, Cui, Zhou, Wenzhong, Ning, Guang +1 more·2020·Endocrine

Abstract

Purpose Thyroid dysfunction has been reported in hypercortisolism. Previous findings regarding changes in thyroid function due to cortisol-producing adenoma (CPA) have been inconsistent. The study aimed to investigate the association between thyroid function and excessive cortisol secretion in patients with CPA and to explore the changes in pituitary function after adrenalectomy.Methods We conducted a retrospective study; thyroid function was evaluated in 94 patients with CPA and 94 healthy controls (HC) matched for age and sex. A total of 94 patients with nonfunctioning adrenal incidentalomas (NFAIs) were recruited as a second control group.Results Serum thyroid stimulating hormone (TSH) and free thyroxine (T4) levels were significantly lower in the CPA group than in the HC and NFAIs groups (P < 0.001). The prevalence of central hypothyroidism was 12.8% in the CPA group and increased according to serum cortisol quartiles (P for trend = 0.025). According to the stepwise multiple linear regression analysis, serum cortisol was negatively associated with TSH and free T4 levels in the CPA group after adjustment for body mass index and age. Furthermore, decreased TSH levels were corrected by adrenalectomy [0.75 (0.50, 1.14) vs. 1.91 (1.36, 2.71) µIU/ml, P < 0.001], in parallel with a recovery in free T4 levels [11.20 (10.00, 12.43) vs. 12.04 (11.24, 13.01), P < 0.001]. Postoperative growth hormone and prolactin levels did not change compared with baseline.Conclusion Serum TSH and free T4 levels were decreased in patients with CPA, and dysfunction of the hypothalamic-pituitary-thyroid axis might be reversible after surgery.

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Crossref · 10.1007/s12020-020-02278-5

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Authors
Cai, R., Zhou, W., Jiang, L., Jiang, Y., Su, T., Zhang, C., Zhou, W., Ning, G., & Wang, W.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Wang, Weiqing
Venue
Endocrine
Published
2020-04-14
Volume
69
Issue
1
Pages
196-203
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
OpenAlex
W3015713101
Cited by
18
References
28
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 4
FWCI
1.83
Type
journal article
Language
en
Open access
closed
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Natural Science Foundation of China (81400779)
  • Shanghai Municipal Commission of Health and Falimiy Planning (201840049)
Topics
  • Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
cortisol-producing adenoma, hypercortisolism, thyroid function, central hypothyroidism, thyroid-stimulating hormone, free thyroxine, adrenalectomy, hypothalamic-pituitary-thyroid axis, pituitary function
MeSH terms
Adenoma, Adrenal Gland Neoplasms, Humans, Hydrocortisone, Retrospective Studies, Thyroid Gland, Thyrotropin

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