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Cited by 365Iron Metabolism and DisordersTrace Elements in HealthNeurological diseases and metabolism

The DOI matches its Crossref record; 21 of the 22 references it cites were found in a registry or an index.

The role of ceruloplasmin in iron metabolism.

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Roeser, H. P., Lee, G. R., Nacht, S., Cartwright, G. E.·1970·Journal of Clinical Investigation
DOI 10.1172/jci106460PMC PMC322742
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Abstract

The importance of ceruloplasmin in iron metabolism was studied in swine made hypoceruloplasminemic by copper deprivation. When the plasma ceruloplasmin level fell below 1% of normal, cell-to-plasma iron flow became sufficiently impaired to cause hypoferremia, even though total body iron stores were normal. When ceruloplasmin was administered to such animals, plasma iron increased immediately and continued to rise at a rate proportional to the logarithm of the ceruloplasmin dose. The administration of inorganic copper induced increases in plasma iron only after ceruloplasmin appeared in the circulation. Thus, ceruloplasmin appeared to be essential to the normal movement of iron from cells to plasma. Studies designed to define the mechanism of action of ceruloplasmin were based on the in vitro observation that ceruloplasmin behaves as an enzyme (ferroxidase) that catalyzes oxidation of ferrous iron. Retention of injected ferrous iron in the plasma of ceruloplasmin-deficient swine was significantly less than that of ferric iron, reflecting impaired transferrin iron binding. Rat ceruloplasmin, which has little ferroxidase activity, was much less effective than porcine or human ceruloplasmin in inducing increases in plasma iron. These observations suggest that ceruloplasmin acts by virtue of its ferroxidase activity. Eight patients with Wilson's disease were evaluated in order to investigate iron metabolism in a disorder characterized by reduced ceruloplasmin levels. Evidence of iron deficiency was found in six of these, and in five of the six, plasma ceruloplasmin was less than 5% of normal. In comparison, the two patients without evidence of iron deficiency had ceruloplasmin levels of 11 and 18% of normal. It is suggested that iron deficiency tends to occur in those patients with Wilson's disease who have the severest degrees of hypoceruloplasminemia, possibly because of defective transfer of iron from intestinal mucosal cells to plasma.

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Research works printed but not linked: 3

  1. H. P. Roeser, G. R. Lee, S. Nacht, and G. E. Cartwright 7. Nacht, S., G. R. Lee, and G. E. Cartwright. 1968. Large scale preparation of porcine ceruloplasmin. Fed. Proc. 27: 482. (Abstr.)
  2. Cartwright, G. E. 1968. Diagnostic Laboratory Hema- tology. Grune & Stratton, Inc., New York. 4th edition.
  3. Broman, L. 1966. The function of ceruloplasmin-a moot question. In Molecular Basis of Some Aspects of Mental Activity. 0. Walaas, editor. Academic Press, Inc., New York. 2: 1502.

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Metadata

Authors
Roeser, H. P., Lee, G. R., Nacht, S., & Cartwright, G. E.
Affiliations
University of Utah (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1970-12-01
Volume
49
Issue
12
Pages
2408-2417
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci106460
PMC
PMC322742
OpenAlex
W1993916376
Cited by
365
References
22
Citations by year
2026: 3 · 2025: 8 · 2024: 8 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 10 · 2018: 8 · 2017: 11 · 2016: 6 · 2015: 3 · 2014: 7 · 2013: 2 · 2012: 3
FWCI
6.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Royal Australasian College of Physicians
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Keywords
ceruloplasmin, iron metabolism, ferroxidase activity, hypoferremia, transferrin iron binding, iron deficiency, Wilson's disease, plasma iron, porcine model
MeSH terms
Animals, Ceruloplasmin, Copper, Deficiency Diseases, Hepatolenticular Degeneration, Humans, Injections, Intravenous, Iron, Protein Binding, Swine, Rats

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