The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
Open accessAbstract
Previous linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was recently found to be associated with a common G-->A polymorphism (UCSNP-43) within the CAPN10 gene. The at-risk genotype was homozygous for the UCSNP-43 G allele. In the present study among Pima Indians, the UCSNP-43 G/G genotype was not associated with an increased prevalence of type 2 diabetes. However, Pima Indians with normal glucose tolerance, who have a G/G genotype at UCSNP-43, were found to have decreased rates of postabsorptive and insulin-stimulated glucose turnover that appear to result from decreased rates of glucose oxidation. In addition, G/G homozygotes were found to have reduced CAPN10 mRNA expression in their skeletal muscle. A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508
Self-citationObesity and insulin resistance: Lessons learned from the Pima indians
Lillioja, S., & Bogardus, C. (1988) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610040508 · Cited by 203
Self-citation
Cited by
Type 2 diabetes: principles of pathogenesis and therapy
Stumvoll, M., Goldstein, B. J., & van Haeften, T. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)61032-x · Cited by 2,662
Generation, Control, and Processing of Cellular Calcium Signals
Carafoli, E., Santella, L., Branca, D., & Brini, M. (2001) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/20014091074183 · Cited by 531
Diabetes mellitus and genetically programmed defects in β-cell function
Bell, G. I., & Polonsky, K. S. (2001) · Nature · doi:10.1038/414788a · Cited by 475
Self-citationThe calpain family and human disease
Huang, Y., & Wang, K. K. W. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02049-4 · Cited by 472
Association of the T-G Polymorphism in Adiponectin (Exon 2) With Obesity and Insulin Sensitivity
Stumvoll, M., Tschritter, O., Fritsche, A., Staiger, H., Renn, W., Weisser, M., Machicao, F., & Häring, H. (2002) · Diabetes · doi:10.2337/diabetes.51.1.37 · Cited by 371
Metadata
- Authors
- Baier, L. J., Permana, P. A., Yang, X., Pratley, R. E., Hanson, R. L., Shen, G.-Q., Mott, D., Knowler, W. C., Cox, N. J., Horikawa, Y., Oda, N., Bell, G. I., & Bogardus, C.
- Venue
- Journal of Clinical Investigation
- Published
- 2000-10-01
- Volume
- 106
- Issue
- 7
- Pages
- R69-R73
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2126785682
- Cited by
- 290
- References
- 2
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. https://app.cochat.ai/papers/10.1172/jci10665
- The paper
- Baier, L. J., Permana, P. A., Yang, X., Pratley, R. E., Hanson, R. L., Shen, G.-Q., Mott, D., Knowler, W. C., Cox, N. J., Horikawa, Y., Oda, N., Bell, G. I., & Bogardus, C. (2000). A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. Journal of Clinical Investigation. https://doi.org/10.1172/jci10665
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
