Diabetes mellitus and genetically programmed defects in β-cell function

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Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus

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Tissue-Specific Knockout of the Insulin Receptor in Pancreatic β Cells Creates an Insulin Secretory Defect Similar to that in Type 2 Diabetes

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

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The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes

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Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα

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Interactions between insulin resistance and insulin secretion in the development of glucose intolerance

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Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus

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Pancreatic β-Cells in Obesity

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Selective Insulin Signaling through A and B Insulin Receptors Regulates Transcription of Insulin and Glucokinase Genes in Pancreatic β Cells

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Transcribing pancreas.

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Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

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Prolonged elevation of plasma free fatty acids impairs pancreatic beta-cell function in obese nondiabetic humans but not in individuals with type 2 diabetes.

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Loss of HNF-1α Function in Mice Leads to Abnormal Expression of Genes Involved in Pancreatic Islet Development and Metabolism

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Treatment with the oral antidiabetic agent troglitazone improves beta cell responses to glucose in subjects with impaired glucose tolerance.

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Hepatocyte Nuclear Factor 4α Regulates the Expression of Pancreatic β-Cell Genes Implicated in Glucose Metabolism and Nutrient-induced Insulin Secretion*

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Calpains Play a Role in Insulin Secretion and Action

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Type 2 Diabetes Mellitus in Children

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Purification of the β-cell glucose-sensitive factor that transactivates the insulin gene differentially in normal and transformed islet cells

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Maternally inherited diabetes and deafness: a new diabetes subtype

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Evidence for a circulating islet cell growth factor in insulin-resistant states

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Maturity-onset diabetes of the young: from clinical description to molecular genetic characterization

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Diverse roles of K(ATP) channels learned from Kir6.2 genetically engineered mice.

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Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.

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Clinical Phenotypes, Insulin Secretion, and Insulin Sensitivity in Kindreds With Maternally Inherited Diabetes and Deafness Due to Mitochondrial tRNALeu(UUR) Gene Mutation

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Noninvasive In Vivo Measurement of β-Cell Mass in Mouse Model of Diabetes

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The Endocrine pancreas and regulation of metabolism

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Effect of Experimental Elevation of Free Fatty Acids on Insulin Secretion and Insulin Sensitivity in Healthy Carriers of the Pro12Ala Polymorphism of the Peroxisome Proliferator–Activated Receptor-γ2 Gene

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Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene).

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Nonsense mutation of islet-1 gene (Q310X) found in a type 2 diabetic patient with a strong family history.

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Diminished Insulin and Glucagon Secretory Responses to Arginine in Nondiabetic Subjects With a Mutation in the Hepatocyte Nuclear Factor–4α/MODY1 Gene

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Using β-Cell Growth Factors to Enhance Human Pancreatic Islet Transplantation*

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Human Insulin Gene Is a Target Gene of Hepatocyte Nuclear Factor-1α (HNF-1α) and HNF-1β

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Changes in Pancreatic Islet Glucokinase and Hexokinase Activities With Increasing Age, Obesity, and the Onset of Diabetes

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Genetically defined forms of diabetes in children

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BETA2 and Pancreatic Islet Development

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Genetic Mapping in Human Disease

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Pathogenesis of type 2 diabetes mellitus

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Control of Pancreas and Liver Gene Expression by HNF Transcription Factors

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Type 2 Diabetes-a Matter of ß-Cell Life and Death?

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Insulin granule dynamics in pancreatic beta cells

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Diabetes associated cell stress and dysfunction: role of mitochondrial and non-mitochondrial ROS production and activity.

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Modeling type 2 diabetes in rats using high fat diet and streptozotocin

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic β cell growth

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FoxO1 protects against pancreatic β cell failure through NeuroD and MafA induction

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A map of open chromatin in human pancreatic islets

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Fibroblast Growth Factor-21 Improves Pancreatic β-Cell Function and Survival by Activation of Extracellular Signal–Regulated Kinase 1/2 and Akt Signaling Pathways

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Loss of ARNT/HIF1β Mediates Altered Gene Expression and Pancreatic-Islet Dysfunction in Human Type 2 Diabetes

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Pathogenesis of Type 2 Diabetes Mellitus

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Chronic Inhibition of Dipeptidyl Peptidase-4 With a Sitagliptin Analog Preserves Pancreatic β-Cell Mass and Function in a Rodent Model of Type 2 Diabetes

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Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes

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A genetic and physiological study of impaired glucose homeostasis control in C57BL/6J mice

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Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

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Intracellular Serotonin Modulates Insulin Secretion from Pancreatic β-Cells by Protein Serotonylation

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Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

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Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity

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A Cluster of Metabolic Defects Caused by Mutation in a Mitochondrial tRNA

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Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance

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Structural and Functional Abnormalities in the Islets Isolated From Type 2 Diabetic Subjects

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Cyclins D2 and D1 Are Essential for Postnatal Pancreatic β-Cell Growth

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The Peroxisome Proliferator-Activated Receptor-γ2 Pro12Ala Polymorphism

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Diabetes mellitus related bone metabolism and periodontal disease

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