The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Estrogen Receptors in Human Breast Cancer
Open accessAbstract
Specific quantitative techniques have been used to measure the cytoplasmic estradiol-binding protein (EBP) in human mammary carcinoma tissue specimens. Sucrose gradient centrifugation reveals EBP to sediment at 8S and 4S. Variable quantities of non-specific estradiol binding occurs in the 4S region of the sucrose gradient necessitating controls to insure specificity of the estradiol protein interaction. Using dextran-coated charcoal to separate bound from free estradiol Scatchard analysis finds the dissociation constant of the estradiol EBP interaction to be approximately 2.6x10(-10) M, indicative of the very high affinity of the ligand for the EBP. Quantitation of EBP sites in 64 primary and metastatic human breast tumors demonstrates a continuous spectrum of values from 0 to 612 fmol per mg of cytoplasmic protein. Specific 8S binding in the sucrose gradient centrifugation was not detected in specimens containing less than 9.0 fmol EBP per mg cytoplasmic protein. Since data from animal breast tumors and preliminary evidence from human breast tumors indicates an excellent correlation between the presence of abundant tumor EBP and endocrine-induced breast cancer regressions, precise quantitation of EBP in all human primary tumors may prove to be an excellent prognosticator of endocrine therapy in metastatic breast cancer.
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Cites
PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT
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THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS
Scatchard, G. (1949) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1949.tb27297.x · Cited by 19,778
A Method for Determining the Sedimentation Behavior of Enzymes: Application to Protein Mixtures
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Radioactive Labeling of Proteins in Vitro
Rice, R. H., & Means, G. E. (1971) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)62484-6 · Cited by 835
Estrogen receptors and breast cancer response to adrenalectomy.
Jensen, E. V., Block, G. E., Smith, S. B., Kyser, K., & DeSombre, E. R. (1971) · PubMed · Cited by 423
Inhibition of human mammary and prostatic cancers by adrenalectomy.
Huggins, C., & Bergenstal, D. M. (1952) · PubMed · Cited by 325
The use of protamine to study [6,7-3H]-oestradiol-17β binding in rat uterus
Steggles, A. W., & King, R. J. B. (1970) · Biochemical Journal · doi:10.1042/bj1180695 · Cited by 130
Estrogen receptor in the rat uterus. Physiological forms and artifacts
Chamness, G. C., & McGuire, W. L. (1972) · Biochemistry · doi:10.1021/bi00763a013 · Cited by 115
Self-citation
Cited by
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
Steroid hormone receptors in breast cancer management
Osborne, C. K. (1998) · Breast Cancer Research and Treatment · doi:10.1023/a:1006132427948 · Cited by 438
Challenges to the measurement of estradiol: an Endocrine Society Position Statement
Rosner, W., Hankinson, S. E., Sluss, P. M., Vesper, H. W., & Wierman, M. E. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3780 · Cited by 408
Baulieu, E.-E., Atger, M., Best-Belpomme, M., Corvol, P., Courvalin, J.-C., Mester, J., Milgrom, E., Robel, P., Rochefort, H., & Catalogne, D. D. (1976) · Vitamins & Hormones · doi:10.1016/s0083-6729(08)60974-7 · Cited by 341
Auto-regulation of the estrogen receptor promoter
Castles, C. G., Oesterreich, S., Hansen, R., & Fuqua, S. A. W. (1997) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(97)00023-x · Cited by 80
Metadata
- Authors
- McGuire, W. L.
- Venue
- Journal of Clinical Investigation
- Published
- 1973-01-01
- Volume
- 52
- Issue
- 1
- Pages
- 73-77
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2091947586
- Cited by
- 668
- References
- 8
- FWCI
- 21.88
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
