The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Determination of Iodothyronine Absorption and Conversion of L-Thyroxine (T4) to L-Triiodothyronine (T3) using Turnover Rate Techniques
Open accessAbstract
The absorption of L-thyroxine (T(4)) and L-triiodothyronine (T(3)) and the fractional rate of conversion of T(4) to T(3) were determined from the turnover rates of T(4) and T(3) in seven patients without endogenous thyroid function during separate treatment periods with these iodothyronines. Serum T(3) concentration was measured by a radioimmunoassay procedure in which the iodothyronines are separated from the plasma proteins before incubation with anti-T(3) antibody. Metabolic clearance rates were calculated by an integral (noncompartmental) approach since the use of single compartment kinetics led to a 40% overestimation of the metabolic clearance rate of T(3). Based on the amount of hormone ingested and the observed hormonal turnover rates, the absorption of T(4) and T(3) (iodothyronine turnover/iodothyronine ingested) in man could be estimated. Absorption of T(3) was complete in three subjects but decreased to 43% in a fourth who was suffering from mild congestive heart failure. Mean T(4) absorption was 48.0+/-2.6% (SEM) for seven subjects. The mean fractional rate of T(4) to T(3) conversion determined during T(4) replacement therapy (T(3) turnover/T(4) turnover) was 42.6% (range 30.7-50.8%). Thus, approximately one-half of the T(4) which was deiodinated was converted to T(3) suggesting that monodeiodination is an obligatory step in the peripheral metabolism of T(4). Calculations based on these results together with other available data suggest that under normal physiologic circumstances the major portion of the T(3) pool is derived from monodeiodination of T(4).
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“In addition, a rare case of TH malabsorption was reported to be induced by congestive heart failure, which may cause intestinal dysfunction and chronic passive congestion of the liver (63).”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [63]
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Cites
Conversion of Thyroxine (T4) to triiodothyronine (T3) in athyreotic human subjects
Braverman, L. E., Ingbar, S. H., & Sterling, K. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106304 · Cited by 485
Determination of Thyroxine Utilizing the Property of Protein-Binding
Murphy, B. E. P., & PATTEE, C. J. (1964) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-24-2-187 · Cited by 349
SPECIFIC NUCLEAR TRIIODOTHYRONINE BINDING SITES IN RAT LIVER AND KIDNEY1
Oppenheimer, J. H., Koerner, D. R., Schwartz, H. L., & Surks, M. I. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-35-2-330 · Cited by 340
Studies of Thyrotropin Physiology by Means of Radioimmunoassay
Odell, W. D., Wilber, J. F., & Utiger, R. D. (1967) · Elsevier eBooks · doi:10.1016/b978-1-4831-9826-2.50005-2 · Cited by 278
Review: The Use of Isotopic Steroids for the Measurement of Production Rates in Vivo1
Tait, J. F. (1963) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-23-12-1285 · Cited by 274
Propylthiouracil inhibits the conversion of l-thyroxine to l-triiodothyronine
Oppenheimer, J. H., Schwartz, H. L., & Surks, M. I. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107063 · Cited by 258
Self-citationSimultaneous Measurement of Thyroxine and Triiodothyronine Peripheral Turnover Kinetics in Man
Nicoloff, J. T., LOW, J. C., Dussault, J. H., & Fisher, D. A. (1972) · Journal of Clinical Investigation · doi:10.1172/jci106835 · Cited by 221
The extrathyroidal conversion rate of thyroxine to triiodothyronine in normal man
Pittman, C. S., Chambers, J. B., & Read, V. H. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106596 · Cited by 214
Direct immunoassay of triiodothyronine in human serum
Larsen, P. R. (1972) · Journal of Clinical Investigation · doi:10.1172/jci107000 · Cited by 205
Simultaneous Estimation of Rates of Thyroxine Degradation and Thyroid Hormone Synthesis1
Ingbar, S. H., & Freinkel, N. (1955) · Journal of Clinical Investigation · doi:10.1172/jci103136 · Cited by 197
Cited by
Sorted by citations
Fish, L. H., Schwartz, H. L., Cavanaugh, J., Steffes, M. W., Bantle, J. P., & Oppenheimer, J. H. (1987) · New England Journal of Medicine · doi:10.1056/nejm198703263161302 · Cited by 353
Regulation of gene expression by thyroid hormone.
Samuels, H. H., FORMAN, B. M., Horowitz, Z. D., & Ye, Z. S. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113449 · Cited by 308
Dietary-induced alterations in thyroid hormone metabolism during overnutrition.
Danforth, E., Horton, E. S., O'Connell, M., Sims, E. A. H., Burger, A., Ingbar, S. H., Braverman, L. E., & Vagenakis, A. G. (1979) · Journal of Clinical Investigation · doi:10.1172/jci109590 · Cited by 315
CHOPRA, I. J. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108456 · Cited by 291
A Radioimmunoassay for Measurement of 3,3′, 5′-Triiodothyronine (Reverse T3)
CHOPRA, I. J. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107795 · Cited by 247
Metadata
- Authors
- Surks, M. I., Schadlow, A. R., Stock, J. M., & Oppenheimer, J. H.
- Affiliations
- Albert Einstein College of Medicine (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1973-04-01
- Volume
- 52
- Issue
- 4
- Pages
- 805-811
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC302327
- OpenAlex
- W2160583708
- Cited by
- 223
- References
- 37
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 16.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- triiodothyronine, T4 to T3 conversion, metabolic clearance rate, thyroid hormone replacement, congestive heart failure, non-compartmental analysis
- MeSH terms
- Absorption, Humans, Hypothyroidism, Iodine Isotopes, Kinetics, Metabolic Clearance Rate, Methods, Radioimmunoassay, Thyroxine, Triiodothyronine
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