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Cited by 223Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentAdrenal Hormones and Disorders

The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.

Determination of Iodothyronine Absorption and Conversion of L-Thyroxine (T4) to L-Triiodothyronine (T3) using Turnover Rate Techniques

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Surks, Martin I., Schadlow, Alan R., Stock, Jerrold M., Oppenheimer, Jack H.·1973·Journal of Clinical Investigation
DOI 10.1172/jci107244PMC PMC302327
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Abstract

The absorption of L-thyroxine (T(4)) and L-triiodothyronine (T(3)) and the fractional rate of conversion of T(4) to T(3) were determined from the turnover rates of T(4) and T(3) in seven patients without endogenous thyroid function during separate treatment periods with these iodothyronines. Serum T(3) concentration was measured by a radioimmunoassay procedure in which the iodothyronines are separated from the plasma proteins before incubation with anti-T(3) antibody. Metabolic clearance rates were calculated by an integral (noncompartmental) approach since the use of single compartment kinetics led to a 40% overestimation of the metabolic clearance rate of T(3). Based on the amount of hormone ingested and the observed hormonal turnover rates, the absorption of T(4) and T(3) (iodothyronine turnover/iodothyronine ingested) in man could be estimated. Absorption of T(3) was complete in three subjects but decreased to 43% in a fourth who was suffering from mild congestive heart failure. Mean T(4) absorption was 48.0+/-2.6% (SEM) for seven subjects. The mean fractional rate of T(4) to T(3) conversion determined during T(4) replacement therapy (T(3) turnover/T(4) turnover) was 42.6% (range 30.7-50.8%). Thus, approximately one-half of the T(4) which was deiodinated was converted to T(3) suggesting that monodeiodination is an obligatory step in the peripheral metabolism of T(4). Calculations based on these results together with other available data suggest that under normal physiologic circumstances the major portion of the T(3) pool is derived from monodeiodination of T(4).

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Metadata

Authors
Surks, M. I., Schadlow, A. R., Stock, J. M., & Oppenheimer, J. H.
Affiliations
Albert Einstein College of Medicine (US)
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1973-04-01
Volume
52
Issue
4
Pages
805-811
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci107244
PMC
PMC302327
OpenAlex
W2160583708
Cited by
223
References
37
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2019: 6 · 2018: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 2 · 2012: 2
FWCI
16.87
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
triiodothyronine, T4 to T3 conversion, metabolic clearance rate, thyroid hormone replacement, congestive heart failure, non-compartmental analysis
MeSH terms
Absorption, Humans, Hypothyroidism, Iodine Isotopes, Kinetics, Metabolic Clearance Rate, Methods, Radioimmunoassay, Thyroxine, Triiodothyronine

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