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Cholesterol Solubility in Bile. EVIDENCE THAT SUPERSATURATED BILE IS FREQUENT IN HEALTHY MAN
Open accessAbstract
The development and validation of a direct method for measuring maximum cholesterol solubility in bile is described. Application of this method to five large mammalian species, including man, produced a micellar zone significantly smaller than that previously reported. Further studies on in vitro model solutions patterned after bile confirmed this new micellar zone. Thus, direct evidence demonstrates that the micellar zone boundary derived in vitro from model solutions is applicable to human gallbladder bile. Using the present criteria, normal human bile, in contrast to bile from other mammalian species, is commonly supersaturated with cholesterol. A male-female difference in bile composition is not demonstrable despite the well-established female preponderance of cholelithiasis. Bile from patients with cholesterol cholelithiasis has a micellar zone similar to normals but differs compositionally in that there is a greater excess of cholesterol above saturation. We conclude that cholesterol supersaturation may be a necessary but not solely sufficient cause for gallstone formation.
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Cited by
Lammert, F., Gurusamy, K., Ko, C. W., Miquel, J.-F., Méndez-Sánchez, N., Portincasa, P., van Erpecum, K. J., van Laarhoven, C. J., & Wang, D. Q.-H. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.24 · Cited by 822
Carey, M. C., & Small, D. M. (1978) · Journal of Clinical Investigation · doi:10.1172/jci109025 · Cited by 699
Portincasa, P., Moschetta, A., & Palasciano, G. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69044-2 · Cited by 643
Broomfield, P. H., Chopra, R., Sheinbaum, R. C., Bonorris, G. G., Silverman, A., Schoenfield, L. J., & Marks, J. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192403 · Cited by 222
Analysis of gallbladder bile in morbid obesity
Freeman, J. B., Meyer, P. D., Printen, K. J., Mason, E. E., & DenBesten, L. (1975) · The American Journal of Surgery · doi:10.1016/0002-9610(75)90292-5 · Cited by 46
Metadata
- Authors
- Holzbach, R. T., Marsh, M., Olszewski, M., & Holan, K.
- Venue
- Journal of Clinical Investigation
- Published
- 1973-06-01
- Volume
- 52
- Issue
- 6
- Pages
- 1467-1479
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2056474881
- Cited by
- 526
- References
- 0
- FWCI
- 50.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Holzbach, R. T., Marsh, M., Olszewski, M., & Holan, K. (1973). Cholesterol Solubility in Bile. EVIDENCE THAT SUPERSATURATED BILE IS FREQUENT IN HEALTHY MAN. Journal of Clinical Investigation. https://doi.org/10.1172/jci107321
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
