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Genetic Factors in Determining Bone Mass
Open accessAbstract
This investigation was undertaken to evaluate possible genetic determinants of bone mass with the premise that inheritance of bone mass could be of etiologic importance in osteoporosis. Bone mass and width measurements were made with the photon absorption technique on the right radius of 71 juvenile and 80 adult twin paris. The variance of intrapair differences of bone mass in monozygotic (MZ) juvenile twins was 0.0013 g(2)/cm(2) compared to 0.0052 g(2)/cm(2) in the dizygotic (DZ) twins. For the adult twins the variance of intrapair differences in bone mass was 0.0069 for MZ and 0.0137 for DZ twins. Similar results were obtained for bone width. The significantly larger variation in intrapair differences in DZ twins indicates that these traits have significant genetic determinants. These intrapair differences were found to increase with age, suggesting that genetic-environmental interaction also contributes to the observed variation in bone mass. These data provide evidence that bone mass does have significant genetic factors, which alone or in conjunction with environmental factors may predispose persons to the development of osteoporosis.
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Citations
Cited by
Pathogenesis of bone fragility in women and men
Seeman, E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08706-8 · Cited by 909
Slemenda, C. W., Longcope, C., Zhou, L., Hui, S. L., Peacock, M., & Johnston, C. C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119701 · Cited by 455
Self-citationSibonga, J. D., Evans, H. J., Sung, H. G., Spector, E. R., Lang, T. F., Oganov, V. S., Bakulin, A. V., Shackelford, L. C., & LeBlanc, A. D. (2007) · Bone · doi:10.1016/j.bone.2007.08.022 · Cited by 242
Liu, S.-Z., Yan, H., Hou, W.-K., Xu, P., Tian, J., Tian, L.-F., Zhu, B.-F., Ma, J., & Lu, S.-M. (2009) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b0920137 · Cited by 18
The roles of adulthood behavioural factors and familial influences in bone density among men
Videman, T., Battié, M. C., Gibbons, L. E., Vanninen, E., Kaprio, J., & Koskenvuo, M. (2002) · Annals of Medicine · doi:10.1080/078538902321012388 · Cited by 15
Metadata
- Authors
- Smith, D. M., Nance, W. E., Kang, K. W., Christian, J. C., & Johnston, C. C.
- Venue
- Journal of Clinical Investigation
- Published
- 1973-11-01
- Volume
- 52
- Issue
- 11
- Pages
- 2800-2808
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2072963204
- Cited by
- 579
- References
- 0
- FWCI
- 6.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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