The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST
Open accessAbstract
Cultures of dividing skin fibroblasts from normal and sclerodermatous human skin have permitted estimations of soluble collagen concentration, net collagen accumulation, cell-doubling times, and the comparison of morphologic and ultrastructural characteristics. In vitro, the scleroderma fibroblast produces more soluble collagen, synthesizes collagen more rapidly, and fourfold more of its protein synthetic activity is directed to collagen production than in the normal skin fibroblast. Cell-doubling times and morphologic and ultrastructural observations of cells in culture have not provided clues to the nature of the biologic defect in the regulation or activation of collagen synthesis by the scleroderma fibroblast.
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Citations
Cites
Connective tissue synthesis by scleroderma skin fibroblasts in cell culture
Leroy, E. C. (1972) · The Journal of Experimental Medicine · doi:10.1084/jem.135.6.1351 · Cited by 201
Self-citation
Cited by
Systemic sclerosis: a prototypic multisystem fibrotic disorder
Varga, J., & Abraham, D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31139 · Cited by 1,163
Regulation of PDGF and its receptors in fibrotic diseases
Bonner, J. C. (2004) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2004.03.006 · Cited by 768
The Biosynthesis of Collagen and Its Disorders
Prockop, D. J., Kivirikko, K. I., Tuderman, L., & Guzman, N. A. (1979) · New England Journal of Medicine · doi:10.1056/nejm197907123010204 · Cited by 574
Igarashi, A., Nashiro, K., Kikuchi, K., Sato, S., Ihn, H., Fujimoto, M., Grotendorst, G. R., & Takehara, K. (1996) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12345771 · Cited by 438
Identification of PLOD2 as Telopeptide Lysyl Hydroxylase, an Important Enzyme in Fibrosis
van der Slot, A. J., Zuurmond, A.-M., Bardoel, A. F. J., Wijmenga, C., Pruijs, H. E. H., Sillence, D. O., Brinckmann, J., Abraham, D. J., Black, C. M., Verzijl, N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307380200 · Cited by 409
Metadata
- Authors
- LeRoy, E. C.
- Venue
- Journal of Clinical Investigation
- Published
- 1974-10-01
- Volume
- 54
- Issue
- 4
- Pages
- 880-889
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2115279208
- Cited by
- 544
- References
- 1
- FWCI
- 8.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST. https://app.cochat.ai/papers/10.1172/jci107827
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- LeRoy, E. C. (1974). Increased Collagen Synthesis by Scleroderma Skin Fibroblasts In Vitro A POSSIBLE DEFECT IN THE REGULATION OR ACTIVATION OF THE SCLERODERMA FIBROBLAST. Journal of Clinical Investigation. https://doi.org/10.1172/jci107827
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
