The DOI matches its Crossref record; 46 of the 48 references it cites were found in a registry or an index.
Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat.
Open accessAbstract
The effects of both synthetic and biologically produced angiotensin II (AII) upon the process of glolerular filtration were examined in the plasma-expanded (2.5% body wt) Munich-Wistar rat, by micropuncture evaluation of pressures, nephron plasma flow (rpf) and filtration rate (sngfr). Plasma expansion was chosen as a control condition because (a) response to AII was uniform and predictable, (b) endogenous generation of AII was presumably suppressed, and (c) the high control values for rpf permitted accurate determination of values for the glomerular permeability coefficient (LpA) before and during AII infusion. With subpressor quantities of synthetic Asn-1, Val-5 AII (less than 5 ng/100 g body wt/min), sngfr fell from 47.7 in the control group to 39.8 nl/min/g kidney (P less than 0.005). The rpf fell to 60% of control values (P less than 0.001). Measurement of glomerular capillary (PG) and Bowman's space (Pt) hydrostatic pressures in surface glomeruli with a servo-nulling device permitted evaluation of the hydrostatic pressure gradient (deltaP = PG - Pi). DeltaP increased from 38.1 +/- 1.2 in control to 45.9 +/- 1.3 mm Hg after Asn-1, Val-5 AII and essentially neutralized the effect of decreased rpf in sngfr. The sngfr then fell as a result of a decreased in LpA from 0.063 +/- 0.008 in control to 0.028 +/- 0.004 nl/s/g kidney/mm Hg after Asn-1, Val-5 AII (P less than 0.02). Lower doses of Asp-1, Ile-5 AII (less than 3 ng/100 g body wt/min) had no effect on sngfr, rpf, deltaP, and afferent and efferent vascular resistance, but significantly elevated systemic blood pressure, suggesting peripheral effects on smooth muscle at this low dose. LpA was 0.044 +/- 0.007 nl/s/g kidney/mm Hg after low-dose Asp-1, Ile-5 AII, and 0.063 +/- 0.008 in the control group (0.02 greater than P greater than 0.1). Higher, equally pressor doses of native AII (5 ng/100 g body wt/min) produced effects almost identical to similar quantites of synthetic Asn-1, Val-5 AII upon rpf, deltaP, sngfr, and renal vascular resistance. LpA again fell to 0.026 +/- 0.004 nl/s/g kidney/mn Hg, a value almost identical to that after the synthetic AII. Paired studies with Asp-1, Ile-5 AII also demonstrated a consistent reduction in LpA.
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“Angiotensin II provides a reduction in the glomerular filtration coefficient KFG (Blantz et al., 1976) via decrease in total filtering surface area because of mesangial cell contraction (Schmitt et al., 1998).”
From Thoroughly Calibrated Modular Agent-Based Model of the Human Cardiovascular and Renal Systems for Blood Pressure Regulation in Health and Disease (2021) · cites this paper as Blantz et al., 1976
Citations
Cites
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Items 401–419 of 419
Heidbreder, E., & Heidland, A. (1989) · Ergebnisse der inneren Medizin und Kinderheilkunde · doi:10.1007/978-3-642-52317-5_1
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Self-citationReiser, J. (2009) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.1159455.619821
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(1992) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.1992.30.10.627
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Loeffler, I., & Wolf, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-99618-1.00011-8
Li, X., Ma, Y., & Xu, G. (2025) · Medical Science Monitor · doi:10.12659/msm.948310
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Physiologische und pathophysiologische Grundlagen der glomerulären Permeabilität für Plasmaproteine
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Angiotensin II Antagonism and Renal Function
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Intrarenal Determinants of GFR Decline During Loop Diuretic Therapy
Pourafshar, N., Nam, C., Madapoosi, S., Choi, M. J., Shah, S., Pitt, B., Xiong, L., Rossignol, P., Unwin, R. J., Testani, J. M., et al. (2026) · Hypertension · doi:10.1161/hypertensionaha.126.27712
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Metadata
- Authors
- Blantz, R. C., Konnen, K. S., & Tucker, B. J.
- Affiliations
- United States Department of Veterans Affairs (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1976-02-01
- Volume
- 57
- Issue
- 2
- Pages
- 419-434
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC436666
- OpenAlex
- W2144447462
- Cited by
- 428
- References
- 48
- Citations by year
- 2026: 3 · 2025: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2013: 2 · 2012: 13
- FWCI
- 11.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Cleveland Clinic
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Nephrology › Renal Diseases and Glomerulopathies
- Health Sciences › Medicine › Nephrology › Renal and Vascular Pathologies
- Keywords
- angiotensin II, glomerular filtration, glomerular microcirculation, plasma flow, hydrostatic pressure gradient, plasma expansion, systemic blood pressure, dose-response relationship, rat kidney
- MeSH terms
- Angiotensin II, Animals, Blood Pressure, Blood Volume, Capillary Permeability, Glomerular Filtration Rate, Hydrostatic Pressure, Kidney Glomerulus, Kidney Tubules, Proximal, Male, Microcirculation, Nephrons, Vascular Resistance, Rats
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