The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Generation of leukotrienes by purified human lung mast cells.
Open accessAbstract
Although mediator release from mast cells and basophils plays a central role in the pathogenesis of human allergic disease, biochemical studies have been restricted to rat peritoneal mast cells and basophilic leukemia cells because they could be easily purified. We have used two new techniques of cell separation to purify human lung mast cells to 98% homogeneity. Lung cell suspensions were obtained by dispersion of chopped lung tissue with proteolytic enzymes. Mast cells were then purified from the suspensions by countercurrent centrifugal elutriation and affinity chromatography. The purified mast cells released both histamine and slow-reacting substance of anaphylaxis (SRS-A) (leukotriene C and D) during stimulation with goat anti-human IgE antibody. Moreover, these preparations were able to generate significant quantities of SRS-A (32 +/- 7 x 10(-17) LTD mole-equivalents/mast cell) at all stages of purification, indicating that a secondary cell is not necessary for the antigen-induced release of SRS.
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Cites
Leukotrienes are potent constrictors of human bronchi
Dahlén, S.-E., Hedqvist, P., Hammarström, S., & Samuelsson, B. (1980) · Nature · doi:10.1038/288484a0 · Cited by 958
An automated continuous-flow system for the extraction and fluorometric analysis of histamine
Siraganian, R. P. (1974) · Analytical Biochemistry · doi:10.1016/0003-2697(74)90093-1 · Cited by 728
STUDIES ON THE MECHANISMS OF HYPERSENSITIVITY PHENOMENA
Lichtenstein, L. M., & Osler, A. G. (1964) · The Journal of Experimental Medicine · doi:10.1084/jem.120.4.507 · Cited by 661
Self-citationHuman lung mast cells: purification and characterization.
Schulman, E. S., MacGlashan, D. W., Peters, S. P., Schleimer, R. P., Newball, H. H., & Lichtenstein, L. M. (1982) · The Journal of Immunology · doi:10.4049/jimmunol.129.6.2662 · Cited by 224
Self-citationRelease of Chemical Mediators from Partially Purified Human Lung Mast Cells
Paterson, N. A. M., Wasserman, S. I., Said, J. W., & Austen, K. F. (1976) · The Journal of Immunology · doi:10.4049/jimmunol.117.4.1356 · Cited by 136
Lichtenstein, L. M. (1971) · The Journal of Immunology · doi:10.4049/jimmunol.107.4.1122 · Cited by 118
Self-citationSHEARD, P., KILLINGBACK, P. G., & Blair, A. M. J. N. (1967) · Nature · doi:10.1038/216283a0 · Cited by 114
The purification of human basophils.
MacGlashan, D. W., & Lichtenstein, L. M. (1980) · The Journal of Immunology · doi:10.4049/jimmunol.124.5.2519 · Cited by 103
Self-citationCentrifugal elutriation (counterstreaming centrifugation) of cells
Pretlow, T. G., & Pretlow, T. P. (1979) · Cell Biophysics · doi:10.1007/bf02781351 · Cited by 62
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Lewis (1990) · doi:10.1056/nejm199009063231006 · Cited by 1,200
Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease
Haeggström, J. Z., & Funk, C. D. (2011) · Chemical Reviews · doi:10.1021/cr200246d · Cited by 875
New insights into the role of the mast cell in asthma.
Brightling, C. E., Bradding, P., Pavord, I. D., & Wardlaw, A. J. (2003) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.2003.01636.x · Cited by 97
Butterfield, J., & Weiler, C. R. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.02.021 · Cited by 41
Butterfield, J. H. (2022) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2022.03.008 · Cited by 27
Metadata
- Authors
- MacGlashan, D. W., Schleimer, R. P., Peters, S. P., Schulman, E. S., Adams, G. K., Newball, H. H., & Lichtenstein, L. M.
- Venue
- Journal of Clinical Investigation
- Published
- 1982-10-01
- Volume
- 70
- Issue
- 4
- Pages
- 747-751
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W1988188055
- Cited by
- 301
- References
- 10
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- MacGlashan, D. W., Schleimer, R. P., Peters, S. P., Schulman, E. S., Adams, G. K., Newball, H. H., & Lichtenstein, L. M. (1982). Generation of leukotrienes by purified human lung mast cells. Journal of Clinical Investigation. https://doi.org/10.1172/jci110670
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
