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Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II.
Open accessAbstract
We have been studying the pathogenesis of adjuvant arthritis in rats using a long-term cell line of T lymphocytes, the A2 line, which can induce polyarthritis and can also be used to vaccinate rats against adjuvant arthritis. Although line A2 was selected for its proliferative response to mycobacteria, it also responded to collagen type II. To elucidate its role of responsiveness to collagen type II and the relationship between arthritogenicity and vaccination, we cloned A2 and selected a subline A2b. We now report that subline A2b, which bore a marker of helper/delayed hypersensitivity T lymphocytes, was strongly arthritogenic, but could not vaccinate against arthritis. Moreover, A2b showed no response to collagen type II. Therefore, reactivity to collagen type II is not a requisite for arthritogenicity, and mediation of arthritis and vaccination can be distinct properties of different populations of T lymphocytes.
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Cited by
Lider, O., Reshef, T., Beraud, E., Ben-Nun, A., & Cohen, I. R. (1988) · Science · doi:10.1126/science.2447648 · Cited by 396
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Borrelli, F., Maffia, P., Pinto, L., Ianaro, A., Russo, A., Capasso, F., & Ialenti, A. (2002) · Fitoterapia · doi:10.1016/s0367-326x(02)00191-0 · Cited by 266
Bonacho, M. G., Cardinali, D. P., Castrillón, P., Cutrera, R. A., & Esquifino, A. I. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00211-4 · Cited by 33
Metadata
- Authors
- Holoshitz, J., Matitiau, A., & Cohen, I. R.
- Venue
- Journal of Clinical Investigation
- Published
- 1984-01-01
- Volume
- 73
- Issue
- 1
- Pages
- 211-215
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2052168585
- Cited by
- 289
- References
- 0
- FWCI
- 12.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. https://app.cochat.ai/papers/10.1172/jci111193
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- Holoshitz, J., Matitiau, A., & Cohen, I. R. (1984). Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II. Journal of Clinical Investigation. https://doi.org/10.1172/jci111193
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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