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Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema.
Open accessAbstract
Atrial natriuretic factor (ANF), a recently sequenced cardiac peptide, has been shown to have potent natriuretic, diuretic, and vasodilating effects in several species. We have developed a radioimmunoassay to measure the levels of immunoreactive ANF in human plasma. Plasma levels of ANF in healthy volunteers on a low sodium diet were 9.8 +/- 1.4 pmol/liter and increased to 21.9 +/- 3.0 on a high sodium diet. The levels of atrial natriuretic factor correlated directly with urinary sodium and inversely with plasma renin activity and plasma aldosterone levels. Patients with marked edema due to congestive heart failure had plasma levels of atrial natriuretic factor five times higher than normal (P less than 0.05), whereas patients with cirrhosis and edema had levels that were not different from normal. These results suggest that atrial natriuretic factor plays an important role in the adaptation to increased sodium intake.
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A critical review of the systolic time intervals.
Lewis, R. P., Rittogers, S. E., Froester, W. F., & Boudoulas, H. (1977) · Circulation · doi:10.1161/01.cir.56.2.146 · Cited by 624
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Schrier, R. W., Arroyo, V., Bernardi, M., Epstein, M., Henriksen, J. H., & Rodés, J. (1988) · Hepatology · doi:10.1002/hep.1840080532 · Cited by 1,623
Heart failure and kidney dysfunction: epidemiology, mechanisms and management
Schefold, J. C., Filippatos, G., Hasenfuss, G., Anker, S. D., & von Haehling, S. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.113 · Cited by 671
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Anand, I. S., Ferrari, R., Kalra, G. S., Wahi, P. L., Poole-Wilson, P. A., & Harris, P. C. (1989) · Circulation · doi:10.1161/01.cir.80.2.299 · Cited by 375
Metadata
- Authors
- Shenker, Y., Sider, R. S., Ostafin, E. A., & Grekin, R. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1985-10-01
- Volume
- 76
- Issue
- 4
- Pages
- 1684-1687
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2045019226
- Cited by
- 325
- References
- 1
- FWCI
- 43.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Shenker, Y., Sider, R. S., Ostafin, E. A., & Grekin, R. J. (1985). Plasma levels of immunoreactive atrial natriuretic factor in healthy subjects and in patients with edema. Journal of Clinical Investigation. https://doi.org/10.1172/jci112154
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
