The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Activation of endogenous factor V by a homocysteine-induced vascular endothelial cell activator.
Open accessAbstract
Vascular endothelium possesses multiple procoagulant properties, including synthesis and expression of Factor V. We studied the effects of homocysteine on the regulation of endothelial cell Factor V activity. Elevated levels of homocysteine are associated with the congenital thrombotic disorder homocystinuria. Treatment of cultured endothelial cells with 0.5-10 mM homocysteine had no effect on cell morphology, but did increase Factor V activity and prothrombin activation by Factor Xa. A radioimmunoassay for endothelial cell Factor V demonstrated that homocysteine treatment did not increase Factor V antigen levels. 125I-prothrombin was activated by treated endothelial cells and Factor Xa in the presence of thrombin inhibitors. Exogenous 125I-Factor V was cleaved by homocysteine-treated but not control endothelial cells. 125I-Factor V cleavage products distinct from those generated by thrombin and Factor Xa were identified. These data provide evidence for regulation of endothelial cell Factor V activity, and indicate that increased Factor V activity associated with homocysteine-treated vascular endothelium results primarily from induction of an activator of Factor V.
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Cited by
Homocysteine and Cardiovascular Disease
Refsum, H., Ueland, P. M., Nygård, O., & Vollset, S. E. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.31 · Cited by 2,180
Homocysteine and Atherothrombosis
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Homocyst(e)ine Decreases Bioavailable Nitric Oxide by a Mechanism Involving Glutathione Peroxidase
Upchurch, G. R., Welch, G. N., Fabian, A. J., Freedman, J. E., Johnson, J. L., Keaney, J. F., & Loscalzo, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.27.17012 · Cited by 668
Decreased Rate of Coronary Restenosis after Lowering of Plasma Homocysteine Levels
Schnyder, G., Roffi, M., Pin, R., Flammer, Y., Lange, H., Eberli, F. R., Meier, B., Turi, Z. G., & Hess, O. M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011364 · Cited by 532
Hofmann, M. A., Lalla, E., Lu, Y., Gleason, M. R., Wolf, B. M., Tanji, N., Ferran, L. J., Kohl, B., Rao, V., Kisiel, W., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci10588 · Cited by 529
Metadata
- Authors
- Rodgers, G. M., & Kane, W. H.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-06-01
- Volume
- 77
- Issue
- 6
- Pages
- 1909-1916
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2158475008
- Cited by
- 384
- References
- 23
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
