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Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells.
Open accessAbstract
Cultured endothelial cells derived from human umbilical veins or bovine aorta produce a potent inhibitor of platelet aggregation. The inhibitor is synthesized from sodium arachidonate or or prostaglandin endoperoxides by a microsomal enzyme system. Tranylcypromine, a specific antagonist of prostacyclin synthetase, suppresses production of the inhibitor by endothelial cells. The inhibitor, which is ether extractable, has been identified using a two-step thin-layer radiochromatographic procedure and a synthetic prostaglandin I2 standard.With this procedure, we have shown that human and bovine endothelial cells convert sodium [3H]arachidonate to radiolabeled prostaglandin I2 and 6-keto-prostaglandin F1alpha, as wellas prostaglandin E2. Thus, endothelial cells may be non-thrombogenic in vivo because they synthesize and release prostaglandin I2, a potent inhibitor of platelet aggregation.
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Cited by
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Krüger-Genge, A., Blocki, A., Franke, R.-P., & Jung, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184411 · Cited by 1,163
Single stretch-activated ion channels in vascular endothelial cells as mechanotransducers?
Lansman, J. B., Hallam, T. J., & Rink, T. J. (1987) · Nature · doi:10.1038/325811a0 · Cited by 697
Medina-Leyte, D. J., Zepeda-García, O., Domínguez-Pérez, M., González-Garrido, A., Villarreal-Molina, T., & Jacobo-Albavera, L. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083850 · Cited by 623
McIntyre, T. M., Zimmerman, G. A., Satoh, K., & Prescott, S. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci111957 · Cited by 422
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Metadata
- Authors
- Weksler, B. B., Marcus, A. J., & Jaffe, E. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1977-09
- Volume
- 74
- Issue
- 9
- Pages
- 3922-3926
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978883377
- Cited by
- 620
- References
- 0
- FWCI
- 35.56
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. https://app.cochat.ai/papers/10.1073/pnas.74.9.3922
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- Weksler, B. B., Marcus, A. J., & Jaffe, E. A. (1977). Synthesis of prostaglandin I2 (prostacyclin) by cultured human and bovine endothelial cells. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.74.9.3922
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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