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Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition.
Open accessAbstract
Human embryonic development involves transition from yolk sac (YS) to liver (L) hemopoiesis. We report the identification of pluripotent, erythroid, and granulo-macrophage progenitors in YS, L, and blood from human embryos. Furthermore, comprehensive studies are presented on the number of hemopoietic progenitors and precursors, as well as of other cell types, in YS, L, and blood at precisely sequential stages in embryos and early fetuses (i.e., at 4.5-8 wk and 9-10 wk postconception, respectively). Our results provide circumstantial support to a monoclonal hypothesis for human embryonic hemopoiesis, based on migration of stem and early progenitor cells from a generation site (YS) to a colonization site (L) via circulating blood. The YS----L transition is associated with development of the differentiation program in proliferating stem cells: their erythroid progeny shows, therefore, parallel switches of multiple parameters, e.g., morphology (megaloblasts----macrocytes) and globin expression (zeta----alpha, epsilon----gamma).
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Citations
Cited by
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840
Origin and differentiation of microglia
Ginhoux, F., Lim, S., Hoeffel, G., Low, D., & Huber, T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00045 · Cited by 905
“Classical lineage tracing studies of blood development in human embryos showed that many essential features of YS hematopoiesis are conserved from mice to humans (Migliaccio et al., 1986; Huyhn et al., 1995; Palis and Yoder, 2001).”
BackgroundOrchestrating liver development
Gordillo, M., Evans, T., & Gouon-Evans, V. (2015) · Development · doi:10.1242/dev.114215 · Cited by 375
Embryonic development of the human hematopoietic system
Tavian, M., & Peault, B. (2005) · The International Journal of Developmental Biology · doi:10.1387/ijdb.041957mt · Cited by 311
Metadata
- Authors
- Migliaccio, G., Migliaccio, A. R., Petti, S., Mavilio, F., Russo, G., Lazzaro, D., Testa, U., Marinucci, M., & Peschle, C.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-07-01
- Volume
- 78
- Issue
- 1
- Pages
- 51-60
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2100543326
- Cited by
- 297
- References
- 0
- FWCI
- 2.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition. https://app.cochat.ai/papers/10.1172/jci112572
- The paper
- Migliaccio, G., Migliaccio, A. R., Petti, S., Mavilio, F., Russo, G., Lazzaro, D., Testa, U., Marinucci, M., & Peschle, C. (1986). Human embryonic hemopoiesis. Kinetics of progenitors and precursors underlying the yolk sac----liver transition. Journal of Clinical Investigation. https://doi.org/10.1172/jci112572
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
