The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization.
Open accessAbstract
Calcitonin receptors have been characterized for the first time in isolated osteoclasts. These receptors have been demonstrated by autoradiographic and biochemical methods, and the cells have also been shown to respond to calcitonin with a dose-dependent increase in cyclic AMP. The receptors in rat osteoclasts are specific and of high affinity (dissociation constant, Kd, 1 to 6 X 10(-10) M), and are present in greater numbers than in any cell previously studied (greater than 10(6) per cell). Chemical cross-linking of 125I-labeled salmon calcitonin to osteoclasts using disuccinimidyl suberate resulted in identification of a receptor component with a relative molecular weight of 80,000-90,000. By counting grains in autoradiographic experiments, we found that greater than 80% of specifically bound radioactivity was associated with multinucleate osteoclasts and the remainder was associated with mononuclear cells that are not osteoblasts, but that may be osteoclast precursors.
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Cites
Calcitonin alters behaviour of isolated osteoclasts
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Functional Properties of Hormonally Responsive Cultured Normal and Malignant Rat Osteoblastic Cells*
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Self-citationCalcitonin Receptors of Kidney and Bone
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Self-citationCalcitonin Receptors in the Central Nervous System of the Rat*
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Cited by
Minireview: The OPG/RANKL/RANK System
Khosla, S. (2001) · Endocrinology · doi:10.1210/endo.142.12.8536 · Cited by 1,515
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Metadata
- Authors
- Nicholson, G. C., Moseley, J. M., Sexton, P. M., Mendelsohn, F. A., & Martin, T. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-08-01
- Volume
- 78
- Issue
- 2
- Pages
- 355-360
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2084376887
- Cited by
- 454
- References
- 39
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization. https://app.cochat.ai/papers/10.1172/jci112584
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- Nicholson, G. C., Moseley, J. M., Sexton, P. M., Mendelsohn, F. A., & Martin, T. J. (1986). Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization. Journal of Clinical Investigation. https://doi.org/10.1172/jci112584
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
