The DOI matches its Crossref record.
Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival.
Open accessAbstract
A purified recombinant human granulocyte-macrophage colony stimulating factor (rH GM-CSF) was a powerful stimulator of mature human eosinophils and neutrophils. The purified rH GM-CSF enhanced the cytotoxic activity of neutrophils and eosinophils against antibody-coated targets, stimulated phagocytosis of serum-opsonized yeast by both cell types in a dose-dependent manner, and stimulated neutrophil-mediated iodination in the presence of zymosan. In addition, rH GM-CSF enhanced N-formylmethionylleucylphenylalanine(FMLP)-stimulated degranulation of Cytochalasin B pretreated neutrophils and FMLP-stimulated superoxide production. In contrast, rH GM-CSF did not promote adherence of granulocytes to endothelial cells or plastic surfaces. rH GM-CSF selectively enhanced the surface expression of granulocyte functional antigens 1 and 2, and the Mo1 antigen. rH GM-CSF induced morphological changes and enhanced the survival of both neutrophils and eosinophils by 6 and 9 h, respectively. These experiments show that granulocyte-macrophage colony stimulating factor can selectively stimulate mature granulocyte function.
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Citations
Cited by
The Human Hematopoietic Colony-Stimulating Factors
Clark, S. C., & Kamen, R. (1987) · Science · doi:10.1126/science.3296190 · Cited by 1,639
Self-citationLee, A., Whyte, M. K. B., & Haslett, C. (1993) · Journal of Leukocyte Biology · doi:10.1002/jlb.54.4.283 · Cited by 714
Djukanović, R., Wilson, J. W., Britten, K. M., Wilson, S. J., Walls, A. F., Roche, W. R., Howarth, P. H., & Holgate, S. T. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.4.863 · Cited by 462
Groopman, J. E., Molina, J.-M., & Scadden, D. T. (1989) · New England Journal of Medicine · doi:10.1056/nejm198911233212106 · Cited by 448
Lloyd, A. R., & Oppenheim, J. J. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90121-m · Cited by 447
Metadata
- Authors
- Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlan, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C., & Vadas, M. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1986-11-01
- Volume
- 78
- Issue
- 5
- Pages
- 1220-1228
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2158528246
- Cited by
- 707
- References
- 0
- FWCI
- 16.21
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. https://app.cochat.ai/papers/10.1172/jci112705
- The paper
- Lopez, A. F., Williamson, D. J., Gamble, J. R., Begley, C. G., Harlan, J. M., Klebanoff, S. J., Waltersdorph, A., Wong, G., Clark, S. C., & Vadas, M. A. (1986). Recombinant human granulocyte-macrophage colony-stimulating factor stimulates in vitro mature human neutrophil and eosinophil function, surface receptor expression, and survival. Journal of Clinical Investigation. https://doi.org/10.1172/jci112705
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
