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Genetic determinants of bone mass in adults. A twin study.
Open accessAbstract
The relative importance of genetic factors in determining bone mass in different parts of the skeleton is poorly understood. Lumbar spine and proximal femur bone mineral density and forearm bone mineral content were measured by photon absorptiometry in 38 monozygotic and 27 dizygotic twin pairs. Bone mineral density was significantly more highly correlated in monozygotic than in dizygotic twins for the spine and proximal femur and in the forearm of premenopausal twin pairs, which is consistent with significant genetic contributions to bone mass at all these sites. The lesser genetic contribution to proximal femur and distal forearm bone mass compared with the spine suggests that environmental factors are of greater importance in the aetiology of osteopenia of the hip and wrist. This is the first demonstration of a genetic contribution to bone mass of the spine and proximal femur in adults and confirms similar findings of the forearm. Furthermore, bivariate analysis suggested that a single gene or set of genes determines bone mass at all sites.
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Cites
Daniell (1976) · doi:10.1001/archinte.1976.03630030032007 · Cited by 301
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Armas, L. A. G., & Recker, R. R. (2012) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2012.04.006 · Cited by 466
Cooper, C., & Melton, L. J. (1992) · Trends in Endocrinology & Metabolism · doi:10.1016/1043-2760(92)90032-v · Cited by 405
Determinants of bone mass in 10- to 26-year-old females: A twin study
Young, D., Hopper, J. L., Nowson, C. A., Green, R. M., Sherwin, J. A., Kaymakci, B., Smid, M., Guest, C. S., Larkins, R. G., & Wark, J. D. (1995) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650100408 · Cited by 189
Self-citationSmoking Is Associated with Lower Bone Mineral Density and Reduced Cortical Thickness in Young Men
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Metadata
- Authors
- Pocock, N. A., Eisman, J. A., Hopper, J. L., Yeates, M. G., Sambrook, P. N., & Eberl, S.
- Venue
- Journal of Clinical Investigation
- Published
- 1987-09-01
- Volume
- 80
- Issue
- 3
- Pages
- 706-710
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2061452312
- Cited by
- 1,250
- References
- 1
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- green
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- Pocock, N. A., Eisman, J. A., Hopper, J. L., Yeates, M. G., Sambrook, P. N., & Eberl, S. (1987). Genetic determinants of bone mass in adults. A twin study. Journal of Clinical Investigation. https://doi.org/10.1172/jci113125
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
