Pathophysiology of Osteoporosis

Armas, Laura A.G.; Recker, Robert R.

doi:10.1016/j.ecl.2012.04.006

Cited by 466Bone health and osteoporosis researchBone Metabolism and DiseasesBone health and treatments

Pathophysiology of Osteoporosis

Armas, Laura A.G., Recker, Robert R.·2012·Endocrinology and Metabolism Clinics of North America

DOI 10.1016/j.ecl.2012.04.006

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Abstract

Understanding of the pathophysiology of osteoporosis has evolved to include compromised bone strength and skeletal fragility caused by several factors: (1) defects in microarchitecture of trabeculae, (2) defective intrinsic material properties of bone tissue, (3) defective repair of microdamage from normal daily activities, and (4) excessive bone remodeling rates. These factors occur in the context of age-related bone loss. Clinical studies of estrogen deprivation, antiresorptives, mechanical loading, and disuse have helped further knowledge of the factors affecting bone quality and the mechanisms that underlie them. This progress has led to several new drug targets in the treatment of osteoporosis.

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“As aging-related osteoporosis typically features low bone mass, microarchitectural alterations and bone marrow adipose tissue expansion40–42, our findings suggest that AD mice at a younger age recapitulate an aged skeletal phenotype.”
From Serum amyloid P secreted by bone marrow adipocytes drives skeletal amyloidosis (2025) · cites this paper as [41]

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Background
LncRNA XIXT promotes osteogenic differentiation of bone mesenchymal stem cells and alleviates osteoporosis progression by targeting miRNA-30a-5p.
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“Most of the drugs available for the treatment of osteoporosis are based on the inhibition of bone resorption activity, which is not sufficient in treating this skeletal disease [2,3].”
Background
IVD fibrosis and disc collapse comprehensively aggravate vertebral body disuse osteoporosis and zygapophyseal joint osteoarthritis by posteriorly shifting the load transmission pattern
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Epimedin C Alleviates Glucocorticoid-Induced Suppression of Osteogenic Differentiation by Modulating PI3K/AKT/RUNX2 Signaling Pathway
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“Osteoporosis is a prevalent bone illness hallmarked by reduced bone density, deterioration of bone microstructure, and decreased bone strength, leading to an elevated risk of fracture (Armas and Recker, 2012; Coughlan and Dockery, 2014).”
Background
Effects of 8-week High-Intensity Interval Training and Moderate-Intensity Continuous Training on Bone Metabolism in Sedentary Young Females
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“The pathogenesis of osteoporosis remain unclear despite previous explorations, but accumulating evidence suggests that vitamin D deficiency is definitely a vital pathogenic factor of osteoporosis (Armas and Recker 2012, Wimalawansa 2019).”
Background
SOD3 regulates FLT1 to affect bone metabolism by promoting osteogenesis and inhibiting adipogenesis through PI3K/AKT and MAPK pathways.
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“The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: O. C. Lee is an AAOS delegate to the Board of the United States Bone and Joint Initiative and US Subcommittee Chair of the Fragility Fracture Network.”
BackgroundInfluential
Resveratrol-loaded nanoplatform RSV@DTPF promote alveolar bone regeneration in OVX rat through remodeling bone-immune microenvironment
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CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression
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“The main cause of OP is the abnormal activation of osteoclasts which are responsible for bone resorption [3].”
Background
Poly(ADP-ribose) polymerase family member 14 promotes functional recovery after spinal cord injury through regulating microglia M1/M2 polarization via STAT1/6 pathway
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“Individuals with SCI often suffer from reduced bone mass and bone integrity, as well as from osteoporosis (Armas and Recker, 2012).”
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Background
High Plasma Sphingosine 1-phosphate Levels Predict Osteoporotic Fractures in Postmenopausal Women: The Center of Excellence for Osteoporosis Research Study
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“Thus, elevated osteoclastic activity among postmenopausal women with relatively higher bone resorption results in the deterioration of bone quality and microarchitecture that will contribute to higher risk for fracture out of proportion to the decreased bone mass.[30] It is possible that compromised bone strength by h…”
Background
Effects of selenium and iodine on Kashin-Beck disease: an updated review
Liu, L., Luo, P., Wen, P.-F., & Xu, P. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1402559 · Cited by 25 · see citing works
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Osteoporosis is under recognized and undertreated in adult spinal deformity patients.
Gupta, A., Cha, T. D., Schwab, J., Fogel, H. A., Tobert, D., Razi, A. E., Paulino, C. B., Hecht, A., Bono, C. M., & Hershman, S. (2021) · Journal of Spine Surgery · doi:10.21037/jss-20-668 · Cited by 25
“That is, both older age and the female gender are correlated with the incidence of osteoporosis (15-17).”
Background
miR-483-3p promotes the osteogenesis of human osteoblasts by targeting Dikkopf 2 (DKK2) and the Wnt signaling pathway
Zhou, B., Peng, K., Wang, G.-Q., Chen, W., Liu, P., Chen, F., & Kang, Y.-J. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4694 · Cited by 25 · see citing works
“Osteoporosis, a systemic metabolic bone disease, which mainly occurs among elderly, thin, post-menopausal women (1-4), with the characteristic features of decreased bone mass, reduced bone quality and a deteriorated microarchitecture, which leads to an increased risk of bone fractures.”
Effects of Chronic Heavy Alcohol Consumption and Endurance Exercise on Cancellous and Cortical Bone Microarchitecture in Adult Male Rats
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“Under some conditions, exercise elicits a net increase in bone mass (Armas and Recker, 2012).”
Research Progress on Icariin Promoting Bone Injury Repair and Regeneration
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“This hormonal shift may lead to a 12% decrease in bone mass within 5–7 years, along with trabecular thinning and cortical porosity [6].”
Application of metabolomics in osteoporosis research
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“However, the upstream targets and other proteins are gradually discovered playing important roles in bone metabolism (Armas and Recker, 2012).”
Background
Targeting Wnt signaling pathway by polyphenols: implication for aging and age-related diseases
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Background
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“242,243 The imbalance between OB-mediated bone formation and OC-mediated bone resorption is the main contributor to OP.”
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Authors: Armas, L. A. G., & Recker, R. R.
Affiliations: CHI Health Creighton University Medical Center - Bergan Mercy (US)
Corresponding author: Armas, Laura A.G.
ORCID: Recker, Robert R.
Venue: Endocrinology and Metabolism Clinics of North America
Publisher: Elsevier BV
Published: 2012-09
Volume: 41
Issue: 3
Pages: 475-486
ISSN: 0889-8529 (ISSN-L)
DOI: 10.1016/j.ecl.2012.04.006
OpenAlex: W9111973
Cited by: 466
References: 69
Citations by year: 2026: 43 · 2025: 62 · 2024: 73 · 2023: 66 · 2022: 72 · 2021: 63 · 2020: 25 · 2019: 8 · 2018: 11 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 16 · 2013: 3 · 2012: 2
FWCI: 1.76
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrinology and Metabolism Clinics of North America (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Health Sciences › Medicine › Oncology › Bone health and treatments
Keywords: osteoporosis, pathophysiology, bone quality, bone microarchitecture, trabecular bone, bone material properties, bone remodeling, age-related bone loss, estrogen deprivation, antiresorptive agents, mechanical loading, disuse
MeSH terms: Animals, Bone and Bones, Female, Humans, Male, Osteoporosis, Osteoporosis, Postmenopausal, Bone Remodeling, Osteoporotic Fractures

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