CoChat
Sign Up
Cited by 158Allergic Rhinitis and SensitizationAsthma and respiratory diseasesMast cells and histamine

Effect of short-term systemic glucocorticoid treatment on human nasal mediator release after antigen challenge.

Open access
Pipkorn, U, Proud, D, Lichtenstein, L M, Schleimer, R P, Peters, S P, Adkinson, N F, Kagey-Sobotka, A, Norman, P S +1 more·1987·Journal of Clinical Investigation
DOI 10.1172/jci113188PMC PMC442332
Open this paper in CoChat — free accountOpen PDF

Abstract

The effect of systemic glucocorticoid treatment on early- and late-phase nasal allergic reactions after allergen challenge was determined in a double-blind, cross-over study in 13 allergic individuals. The subjects were pretreated for 2 d before challenge with 60 mg prednisone per day or a matching placebo. A previously described model using repeated nasal lavages for measuring mediator release in vivo was utilized. Symptom scores obtained repeatedly before, during, and after the challenge and the number and timing of sneezes were recorded. The mediators measured were histamine. N-alpha-p-tosyl-L-arginine methyl ester (TAME)-esterase activity, kinins, PGD2, and LTC4/D4. Albumin was also measured as a marker of plasma transudation. Blood samples were taken for determination of total number of white blood cells, differential count, and total blood histamine content. No effect of steroid therapy was found on the appearance of symptoms or any of the mediators, except a reduction in kinins, in the early phase of the allergic reaction. However, in the late phase, the prednisone reduced the number of sneezes (P less than 0.01), as well as the level of histamine (P less than 0.05), TAME-esterase activity (P less than 0.05), kinins (P less than 0.05), and albumin (P less than 0.05). Only low levels of leukotrienes were found in the late phase, but the quantities of these mediators seemed to be decreased by the glucocorticoid treatment (P = 0.06). PGD2 did not increase during the LPR and thus was not affected by glucocorticosteroids. The immediate response to a second challenge 11 h after the first was also evaluated. Whereas the appearance of mediators was enhanced over the initial response to the same challenge dose in placebo-treated subjects, this enhancement was abrogated after prednisone treatment. As this dose of drug is known to be clinically effective in treating hay fever, the present study confirms the earlier findings of others that short-term systemic glucocorticoid treatment inhibits the late phase but not the immediate phase of antigen challenge. Furthermore, secondary enhancement of immediate responses is inhibited. This study shows that glucocorticoids inhibit the generation or release of inflammatory mediators during the late reaction and the physiologic response.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1172/jci113188

Cites

26 of 26 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Topical steroid treatment suppresses the wheal and flare reaction in treated skin areas, creating the possibility of false-negative test results.

    “Topical steroid treatment has been demonstrated to suppress the wheal and flare reaction in treated skin areas, creating the possibility of false-negative test results.882-885”

    From International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis (2018) · cites this paper as [884]

    The Methods describe oral prednisone, not topical treatment of skin. The Results report that skin-test wheal size did not change after that systemic treatment. Our copy does not address whether topical steroids suppress reactions in treated skin or cause false-negative tests (searched: topical steroid, wheal and flare, false negative). (LLM, conf=0.76)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Pipkorn, U., Proud, D., Lichtenstein, L. M., Schleimer, R. P., Peters, S. P., Adkinson, N. F., Kagey-Sobotka, A., Norman, P. S., & Naclerio, R. M.
Affiliations
Johns Hopkins University (US)
ORCID
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1987-10-01
Volume
80
Issue
4
Pages
957-961
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci113188
PMC
PMC442332
OpenAlex
W2082209877
Cited by
158
References
26
Citations by year
2024: 1 · 2023: 1 · 2018: 1 · 2016: 2 · 2015: 3 · 2014: 4 · 2013: 1
FWCI
5.44
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Investigation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Pfizer
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (AI-20136, AI08270, AI-04866)
Topics
  • Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
  • Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
  • Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Keywords
glucocorticoids, prednisone, allergic rhinitis, late-phase allergic reaction, histamine, kinins, leukotrienes, prostaglandin D2, sneezing, allergen challenge, nasal irrigation
MeSH terms
Administration, Intranasal, Aerosols, Chromatography, High Pressure Liquid, Double-Blind Method, Histamine, Histamine Release, Humans, Hypersensitivity, Kinins, Leukocyte Count, Nasal Mucosa, Peptide Hydrolases, Pollen, Prednisone, Prostaglandins D, Random Allocation, Serum Albumin, Sneezing, SRS-A, Prostaglandin D2

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review