Cited by 104Circadian rhythm and melatoninStress Responses and CortisolImmunotoxicology and immune responses

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Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

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Lévi, F A, Canon, C, Touitou, Y, Reinberg, A, Mathé, G·1988·Journal of Clinical Investigation

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Abstract

A seasonal modulation of the circadian time structure of circulating T and natural killer (NK) lymphocyte subtypes was documented in five healthy men aged 24-36 yr. Venous blood was obtained every 4 h for 24 h from each subject in January, March, June, August, and November 1984. Three subjects were also studied in April and/or August and/or November 1983 for the T subsets only. Mononuclear cells were isolated on Ficoll-Paque gradient and aliquots were incubated with OKT3, OKT4, OKT8, or HNK-1 monoclonal antibodies for characterizing all, T, T helper, T suppressor-cytotoxic, and NK lymphocytes, respectively, under an epifluorescence microscope. An effect of both sampling time and study month was statistically validated (P less than 0.01) with both two-way analysis of variance and cosinor for the peripheral counts in total, pan-T, T helper, and NK lymphocytes (cells per cubic millimeter). Seasonal changes affected both the circadian patterns and the 24-h mean values. Thus the double amplitude (total extent of variation) of the circadian rhythm in circulating total, T and T helper lymphocytes varied between 0 in March (P greater than 0.30; no rhythm) and up to 46-68% of the 24-h-mean (M) in November, with acrophases (times of maximum, 0) localized in the first half of the night (P less than 0.001). Maximal values were found at 8:30 h for both T suppressor-cytotoxic and NK lymphocytes; a smaller second peak was also found at 20:30 h, and a 12-h rhythm was validated by cosinor (P less than 0.0001), with no patient change in waveform along the year scale. A circannual rhythm was statistically validated by cosinor for total (0 in November), pan-T (0 in March), T suppressor-cytotoxic (0 in December), and NK lymphocytes (0 in October). A rhythm with a period equal to 6 mo was found for circulating T helper cells with 0 occurring both in April and October. Seasonal variations in the incidence of several immunologically related diseases may correspond to an endogenous circannual time structure.

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Authors: Lévi, F. A., Canon, C., Touitou, Y., Reinberg, A., & Mathé, G.
Affiliations: Centre National de la Recherche Scientifique (FR)
Pitié-Salpêtrière Hospital (FR)
ORCID: Lévi, F A
Touitou, Y
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1988-02-01
Volume: 81
Issue: 2
Pages: 407-413
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci113333
PMC: PMC329583
OpenAlex: W1964130172
Cited by: 104
References: 47
Citations by year: 2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 4 · 2018: 1 · 2015: 1 · 2014: 4 · 2013: 4
FWCI: 3.51
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: circadian rhythm, seasonal variation, T cells, natural killer cells, T helper cells, suppressor/cytotoxic T cells, lymphocyte subsets, circannual rhythm, peripheral blood lymphocyte count, healthy men
MeSH terms: Adult, Antibodies, Monoclonal, Circadian Rhythm, Humans, Killer Cells, Natural, Leukocyte Count, Male, Seasons, T-Lymphocytes

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Seasonal modulation of the circadian time structure of circulating T and natural killer lymphocyte subsets from healthy subjects.

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