The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Tumor necrosis factor and the acute metabolic response to tissue injury in man.
Open accessAbstract
Tumor necrosis factor (cachectin), a protein produced by monocytes and macrophages, has been implicated as an important mediator of the lethal effects of endotoxic shock and the cachexia of chronic infection. Recombinant human tumor necrosis factor alpha (rTNF) was given intravenously to patients as part of an antineoplastic trial. Fever, tachycardia, and at higher doses, hypotension occurred after a single injection of rTNF. Metabolic effects after rTNF administration were dose related and included enhanced energy expenditure with elevated CO2 production, increased whole body protein metabolism and peripheral amino acid efflux from the forearm, and decreased total arterial amino acid levels associated with a significant increase in plasma cortisol. Elevated serum triglycerides, as well as increased glycerol and free fatty acid turnover were seen, suggesting increased whole body lipolysis and fat utilization after rTNF. These findings indicate that administration of TNF in man reproduces many of the acute physiologic and metabolic responses to tissue injury, including energy substrate mobilization.
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Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 1×
“The studies of Cerami and coworkers have implicated TNF in the lethal effects of endotoxin (7, 8) and have recently shown that an MAb against TNF protects against lethal bacteremia (32, 33).”
BackgroundBeutler, B., Milsark, I. W., & Cerami, A. C. (1985) · Science · doi:10.1126/science.3895437 · Cited by 2,352
Microdetermination of Long-chain Fatty Acids in Plasma and Tissues
Dole, V. P., & Meinertz, H. (1960) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)76920-8 · Cited by 2,200
Cachectin and tumour necrosis factor as two sides of the same biological coin
Beutler, B., & Cerami, A. (1986) · Nature · doi:10.1038/320584a0 · Cited by 1,647
THE PHENOMENON OF THE ACUTE PHASE RESPONSE*
Kushner, I. (1982) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1982.tb22124.x · Cited by 1,479
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J., Ulevitch, R., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,131
Catecholamines: Znediator of the Hypermetabolic Response to Thermal Injury
WILMORE, D. W., LONG, J. M., MASON, A. D., SKREEN, R. W., & PRUITT, B. A. (1974) · Annals of Surgery · doi:10.1097/00000658-197410000-00031 · Cited by 753
Combined Hormonal Infusion Simulates the Metabolic Response to Injury
BESSEY, P. Q., WAITERS, J. M., AOKI, T. T., & WILMORE, D. W. (1984) · Annals of Surgery · doi:10.1097/00000658-198409000-00004 · Cited by 446
Cited by
Khovidhunkit, W., Kim, M.-S., Memon, R. A., Shigenaga, J. K., Moser, A. H., Feingold, K. R., & Grunfeld, C. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r300019-jlr200 · Cited by 1,481
Multiple Organ Failure Pathophysiology and Potential Future Therapy
DEITCH, E. A. (1992) · Annals of Surgery · doi:10.1097/00000658-199208000-00002 · Cited by 1,380
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665
Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin.
Ashkenazi, A., Marsters, S. A., Capon, D. J., Chamow, S. M., Figari, I. S., Pennica, D., Goeddel, D. V., Palladino, M. A., & Smith, D. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10535 · Cited by 275
Bagby, G. J., Plessala, K. J., Wilson, L. A., Thompson, J. J., & Nelson, S. (1991) · Journal of Infectious Diseases · doi:10.1093/infdis/163.1.83 · Cited by 273
Metadata
- Authors
- Starnes, H. F., Warren, R. S., Jeevanandam, M., Gabrilove, J. L., Larchian, W., Oettgen, H. F., & Brennan, M. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1988-10-01
- Volume
- 82
- Issue
- 4
- Pages
- 1321-1325
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2150483885
- Cited by
- 300
- References
- 28
- FWCI
- 22.92
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Tumor necrosis factor and the acute metabolic response to tissue injury in man. https://app.cochat.ai/papers/10.1172/jci113733
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- Starnes, H. F., Warren, R. S., Jeevanandam, M., Gabrilove, J. L., Larchian, W., Oettgen, H. F., & Brennan, M. F. (1988). Tumor necrosis factor and the acute metabolic response to tissue injury in man. Journal of Clinical Investigation. https://doi.org/10.1172/jci113733
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
