The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Divergent Efficacy of Antibody to Tumor Necrosis Factor- in Intravascular and Peritonitis Models of Sepsis
Abstract
The role of tumor necrosis factor-alpha (TNF alpha) in the lethal consequences of intravascular lipopolysaccharide (LPS) or Escherichia coli sepsis was compared with that in bacterial peritonitis. Intravenous administration of E. coli LPS or E. coli (live or dead) resulted in large transient increases in serum TNF alpha levels, peaking at 90 min at 10,000-30,000 units/ml. In contrast, the serum TNF alpha response following the induction of bacterial peritonitis was substantially less, peaking at 200-500 units/ml. Sterile peritonitis (essentially nonlethal) and bacterial peritonitis (greater than 60% lethal) elevated TNF alpha levels to 1000-2000 units/lavage within the peritoneal cavity 2 h after challenge. Passive immunization with neutralizing goat anti-TNF alpha IgG improved survival from 8% to 75% in rats administered LPS intravenously but was completely ineffective in protecting rats from lethal E. coli peritonitis. Thus significant differences exist in the role TNF alpha plays in systemic intravascular models of sepsis and bacterial peritonitis.
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Cites
Shock and Tissue Injury Induced by Recombinant Human Cachectin
Tracey, K. J., Beutler, B., Lowry, S. F., Merryweather, J., Wolpe, S., Milsark, I. W., Hariri, R. J., Fahey, T. J., Zentella, A., Albert, J. D., et al. (1986) · Science · doi:10.1126/science.3764421 · Cited by 2,549
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448 · cited 4×
“coli [10-12].”
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Cachectin: More Than a Tumor Necrosis Factor
Epstein, F. H., Beutler, B., & Cerami, A. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702123160705 · Cited by 1,432
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
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Cachectin/tumor necrosis factor induces lethal shock and stress hormone responses in the dog.
Tracey, K. J., Lowry, S. F., Fahey, T. J., Albert, J. D., Fong, Y., HESSE, D. G., Beutler, B., Manogue, K. R., Calvano, S. E., & Hu, W. M. (1987) · PubMed · Cited by 429
Cited by
Treatment of Septic Shock with the Tumor Necrosis Factor Receptor:Fc Fusion Protein
Fisher, C. J., Agosti, J. M., Opal, S. M., Lowry, S. F., Balk, R. A., Sadoff, J. C., Abraham, E., Schein, R. M. H., & Benjamin, E. (1996) · New England Journal of Medicine · doi:10.1056/nejm199606273342603 · Cited by 1,241
Balance of inflammatory cytokines related to severity and mortality of murine sepsis
Walley, K. R., Lukacs, N. W., Standiford, T. J., Strieter, R. M., & Kunkel, S. L. (1996) · Infection and Immunity · doi:10.1128/iai.64.11.4733-4738.1996 · Cited by 366
Biologic Control of Injury and Inflammation: Much More than Too Little or Too Late
Guirao, X., & Lowry, S. F. (1996) · World Journal of Surgery · doi:10.1007/s002689900069 · Cited by 102
Metadata
- Authors
- Bagby, G. J., Plessala, K. J., Wilson, L. A., Thompson, J. J., & Nelson, S.
- Venue
- Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 1991-01-01
- Volume
- 163
- Issue
- 1
- Pages
- 83-88
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- OpenAlex
- W2030235062
- Cited by
- 273
- References
- 24
- FWCI
- 17.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Divergent Efficacy of Antibody to Tumor Necrosis Factor- in Intravascular and Peritonitis Models of Sepsis. https://app.cochat.ai/papers/10.1093/infdis/163.1.83
- The paper
- Bagby, G. J., Plessala, K. J., Wilson, L. A., Thompson, J. J., & Nelson, S. (1991). Divergent Efficacy of Antibody to Tumor Necrosis Factor- in Intravascular and Peritonitis Models of Sepsis. Journal of Infectious Diseases. https://doi.org/10.1093/infdis/163.1.83
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
