Cited by 265Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and TherapyProtein Tyrosine Phosphatases

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pp60c-src activation in human colon carcinoma.

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Cartwright, C A, Kamps, M P, Meisler, A I, Pipas, J M, Eckhart, W·1989·Journal of Clinical Investigation

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Abstract

We measured the in vitro protein-tyrosine kinase activity of pp60c-src from human colon carcinoma cell lines and tumors. The activity of pp60c-src from six of nine carcinoma cell lines was higher (on average, fivefold as measured by enolase phosphorylation, or eightfold as measured by autophosphorylation) than that of pp60c-src from normal colonic mucosal cells, or human or rodent fibroblasts. Similarly, the activity of pp60c-src from 13 of 21 primary colon carcinomas was five- or sevenfold higher than that of pp60c-src from normal colonic mucosa adjacent to the tumor. The increased pp60c-src activity did not result solely from an increase in the level of pp60c-src protein, suggesting the specific activity of the pp60c-src kinase is elevated in the tumor cells. pp60c-src from colon carcinoma cells and normal colonic mucosal cells was phosphorylated at similar sites. We used immunoblotting with antibodies to phosphotyrosine to identify substrates of protein-tyrosine kinases in colonic cells. Three phosphotyrosine-containing proteins were detected at significantly higher levels in most colon carcinoma cell lines than in normal colonic mucosal cells or human or rat fibroblasts. All colon carcinoma cell lines with elevated pp60c-src in vitro kinase activity, showed increased phosphorylation of proteins on tyrosine in vivo, suggesting the presence of an activated protein-tyrosine kinase(s).

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Authors: Cartwright, C. A., Kamps, M. P., Meisler, A. I., Pipas, J. M., & Eckhart, W.
Affiliations: Salk Institute for Biological Studies (US)
ORCID: Pipas, J M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1989-06-01
Volume: 83
Issue: 6
Pages: 2025-2033
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci114113
PMC: PMC303927
OpenAlex: W2121881330
Cited by: 265
References: 72
Citations by year: 2024: 2 · 2023: 5 · 2022: 2 · 2021: 3 · 2020: 2 · 2018: 2 · 2017: 5 · 2016: 5 · 2015: 4 · 2014: 8 · 2013: 5 · 2012: 8
FWCI: 1.94
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (CA 14195, CA-13884, CA-01040)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Mechanisms and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: Src kinase, tyrosine kinase, colon cancer, kinase activation, autophosphorylation, colonic mucosa, cancer cell lines, oncogene expression
MeSH terms: Carcinoma, Cell Line, Colonic Neoplasms, Enzyme Activation, Humans, Intestinal Mucosa, Phosphoproteins, Phosphorylation, Protein-Tyrosine Kinases, Proto-Oncogene Proteins, Retroviridae Proteins, Tumor Cells, Cultured, Tyrosine, Oncogene Protein pp60(v-src)

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pp60c-src activation in human colon carcinoma.

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