The DOI matches its Crossref record.
Clonality and altered behavior of endothelial cells from hemangiomas
Open accessAbstract
Hemangioma, the most common tumor of infancy, is a benign vascular neoplasm of unknown etiology. We show, for the first time to our knowledge, that endothelial cells from proliferating hemangioma are clonal, and we demonstrate that these hemangioma-derived cells differ from normal endothelial cells in their rates of proliferation and migration in vitro. Furthermore, migration of hemangioma endothelial cells is stimulated by the angiogenesis inhibitor endostatin, unlike the inhibition seen with normal endothelial cells. We conclude that hemangiomas constitute clonal expansions of endothelial cells. This is consistent with the possibility that these tumors are caused by somatic mutations in one or more genes regulating endothelial cell proliferation.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Munden, A., Butschek, R., Tom, W. L., Marshall, J. S., Poeltler, D. M., Krohne, S. E., Alió, A. B., Ritter, M., Friedlander, D. F., Catanzarite, V., et al. (2014) · British Journal of Dermatology · doi:10.1111/bjd.12804 · Cited by 317
Medici, D., Potenta, S., & Kalluri, R. (2011) · Biochemical Journal · doi:10.1042/bj20101500 · Cited by 316
Greenberger, S., Yuan, S., Walsh, L. A., Boscolo, E., Kang, K.-T., Matthews, B., Mulliken, J. B., & Bischoff, J. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.300 · Cited by 94
Self-citationMolecular heterogeneity of tumor endothelium
Aird, W. C. (2009) · Cell and Tissue Research · doi:10.1007/s00441-008-0672-y · Cited by 66
Metadata
- Authors
- Boye, E., Yu, Y., Paranya, G., Mulliken, J. B., Olsen, B. R., & Bischoff, J.
- Venue
- Journal of Clinical Investigation
- Published
- 2001-03-15
- Volume
- 107
- Issue
- 6
- Pages
- 745-752
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2096730311
- Cited by
- 298
- References
- 0
- FWCI
- 13.04
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Clonality and altered behavior of endothelial cells from hemangiomas. https://app.cochat.ai/papers/10.1172/jci11432
- The paper
- Boye, E., Yu, Y., Paranya, G., Mulliken, J. B., Olsen, B. R., & Bischoff, J. (2001). Clonality and altered behavior of endothelial cells from hemangiomas. Journal of Clinical Investigation. https://doi.org/10.1172/jci11432
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
