The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling
Open accessAbstract
EndMT (endothelial–mesenchymal transition) is a critical process of cardiac development and disease progression. However, little is know about the signalling mechanisms that cause endothelial cells to transform into mesenchymal cells. In the present paper we show that TGF-β2 (transforming growth factor-β2) stimulates EndMT through the Smad, MEK [MAPK (mitogen-activated protein kinase)/ERK (extracellular-signal-regulated kinase) kinase], PI3K (phosphinositide 3-kinase) and p38 MAPK signalling pathways. Inhibitors of these pathways prevent TGF-β2-induced EndMT. Furthermore, we show that all of these pathways are essential for increasing expression of the cell-adhesion-suppressing transcription factor Snail. Inhibition of Snail with siRNA (small interfering RNA) prevents TGF-β2-induced EndMT. However, overexpression of Snail is not sufficient to cause EndMT. Chemical inhibition of GSK-3β (glycogen synthase kinase-3β) allows EndMT to be induced by Snail overexpression. Expression of a mutant Snail protein that is resistant to GSK-3β-dependent inactivation also promotes EndMT. These results provide the foundation for understanding the roles of specific signalling pathways in mediating EndMT.
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1 retracted
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RetractedThe phosphoinositide 3-kinase pathway
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Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
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Endothelial-to-mesenchymal transition contributes to cardiac fibrosis
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Self-citationEpithelial–mesenchymal transitions in development and pathologies
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Self-citationFibroblasts in Kidney Fibrosis Emerge via Endothelial-to-Mesenchymal Transition
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Cited by
Molecular mechanisms of epithelial–mesenchymal transition
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Yang, D.-R., Wang, M.-Y., Zhang, C.-L., & Wang, Y. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359255 · Cited by 280
Endothelial-to-Mesenchymal Transition in Cancer
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Endothelial Cells in the Tumor Microenvironment
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Metadata
- Authors
- Medici, D., Potenta, S., & Kalluri, R.
- Venue
- Biochemical Journal
- Publisher
- Portland Press Ltd.
- Published
- 2011-07-13
- Volume
- 437
- Issue
- 3
- Pages
- 515-520
- ISSN
- 0264-6021 (ISSN-L)
- 1470-8728
- OpenAlex
- W2131432937
- Cited by
- 316
- References
- 33
- FWCI
- 5.17
- Type
- journal article
- Language
- en
- Open access
- green
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- Medici, D., Potenta, S., & Kalluri, R. (2011). Transforming growth factor-β2 promotes Snail-mediated endothelial–mesenchymal transition through convergence of Smad-dependent and Smad-independent signalling. Biochemical Journal. https://doi.org/10.1042/bj20101500
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