The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils.
Open accessAbstract
Anti-neutrophil cytoplasmic autoantibodies (ANCA) specifically associated with Wegener's granulomatosis were found to be directed against a saline-soluble glycoprotein triplet that migrates on SDS gels as distinct bands of Mr 29,000, 30,500, and 32,000 and is present in the azurophilic granules. This antigen was specifically recognized by all cytoplasmic-staining (C)-ANCA-positive sera from patients with Wegener's disease. C-ANCA antigen bound [3H]diisopropylfluorophosphate, which indicates that it is a serine protease, but it could clearly be distinguished from the serine proteases elastase and cathepsin G. Stimulation of cytochalasin B-treated neutrophils with FMLP induced release of C-ANCA antigen. This indicates that in vivo C-ANCA might interact with the C-ANCA antigen after its release upon inflammatory stimulation. We further demonstrate that in some perinuclear staining (P-ANCA) patients' sera autoantibodies against other myeloid lysosomal enzymes can be detected, such as antimyeloperoxidase and antielastase. C-ANCA and P-ANCA thus represent a novel class of autoantibodies directed against myeloid lysosomal enzymes. The originally described Wegener-specific C-ANCA show an apparently uniform specificity for the 29,000 serine protease. In contrast, P-ANCA may recognize myeloperoxidase as well as elastase and/or other antigens.
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Cites
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Segmental necrotising glomerulonephritis with antineutrophil antibody: possible arbovirus aetiology?
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WEGENERʼS GRANULOMATOSIS: STUDIES IN EIGHTEEN PATIENTS AND A REVIEW OF THE LITERATURE
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Cited by
Falk, R. J., Hogan, S., Carey, T. S., Jennette, J. C., & The Glomerular Disease Collaborative Network (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-9-656 · Cited by 391
Clinical significance of anti-neutrophil cytoplasmic antibodies (ANCA) in autoimmune liver diseases
Roozendaal, C., Jong, M. A. D., Berg, A. P. V. D., Wijk, R. T. V., Limburg, P. C., & Kallenberg, C. G. M. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80241-x · Cited by 100
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Metadata
- Authors
- Goldschmeding, R., van der Schoot, C. E., ten Bokkel Huinink, D., Hack, C. E., van den Ende, M. E., Kallenberg, C. G., & von dem Borne, A. E.
- Venue
- Journal of Clinical Investigation
- Published
- 1989-11-01
- Volume
- 84
- Issue
- 5
- Pages
- 1577-1587
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2170737062
- Cited by
- 432
- References
- 15
- FWCI
- 43.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. https://app.cochat.ai/papers/10.1172/jci114335
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- Goldschmeding, R., van der Schoot, C. E., ten Bokkel Huinink, D., Hack, C. E., van den Ende, M. E., Kallenberg, C. G., & von dem Borne, A. E. (1989). Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. Journal of Clinical Investigation. https://doi.org/10.1172/jci114335
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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