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Wegener's Granulomatosis: Prospective Clinical and Therapeutic Experience With 85 Patients for 21 Years
Abstract
Eighty-five patients with Wegener's granulomatosis were studied for 21 years at the National Institutes of Health. Patients were treated with a protocol consisting of cyclophosphamide, 2 mg/kg body weight d, together with prednisone, 1 mg/kg body weight d, followed by conversion of the prednisone to an alternate-day regimen. Complete remissions were achieved in 79 of 85 patients (93%). The mean duration of remission for living patients was 48.2 (+/- 3.6) months. Twenty-three patients are off all therapy for a mean duration of 35.3 (+/- 6.3) months without therapy. This study provides a prospective experience with Wegener's granulomatosis and shows that long-term remissions can be induced and maintained in an extremely high number of patients by the combination of daily cyclophosphamide and alternate-day prednisone therapy.
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Cited by
Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis
Stone, J. H., Merkel, P. A., Spiera, R., Seo, P., Langford, C. A., Hoffman, G. S., Kallenberg, C. G. M., St. Clair, E. W., Turkiewicz, A., Tchao, N. K., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa0909905 · Cited by 2,762
Jayne, D., Rasmussen, N., Andrassy, K., Bacon, P., Tervaert, J. W. C., Dadoniené, J., Ekstrand, A., Gaskin, G., Gregorini, G., de Groot, K., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa020286 · Cited by 1,348
Long-term patient survival in ANCA-associated vasculitis
Flossmann, O., Berden, A., de Groot, K., Hagen, C., Harper, L., Heijl, C., Höglund, P., Jayne, D., Luqmani, R., Mahr, A., et al. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.137778 · Cited by 939
Goldschmeding, R., van der Schoot, C. E., ten Bokkel Huinink, D., Hack, C. E., van den Ende, M. E., Kallenberg, C. G., & von dem Borne, A. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114335 · Cited by 432
Falk, R. J., Hogan, S., Carey, T. S., Jennette, J. C., & The Glomerular Disease Collaborative Network (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-9-656 · Cited by 391
Metadata
- Authors
- FAUCI, A. S., HAYNES, B. F., KATZ, P., & WOLFF, S. M.
- Venue
- Annals of Internal Medicine
- Publisher
- American College of Physicians
- Published
- 1983-01-01
- Volume
- 98
- Issue
- 1
- Pages
- 76-85
- ISSN
- 0003-4819 (ISSN-L)
- 1539-3704
- OpenAlex
- W2109207289
- Cited by
- 2,001
- References
- 0
- FWCI
- 53.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Wegener's Granulomatosis: Prospective Clinical and Therapeutic Experience With 85 Patients for 21 Years. https://app.cochat.ai/papers/10.7326/0003-4819-98-1-76
- The paper
- FAUCI, A. S., HAYNES, B. F., KATZ, P., & WOLFF, S. M. (1983). Wegener's Granulomatosis: Prospective Clinical and Therapeutic Experience With 85 Patients for 21 Years. Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-98-1-76
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