The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
L-arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats.
Open accessAbstract
This study examined the contribution of nitric oxide (NO) to the susceptibility or resistance to the hypertensive effects of high sodium chloride (8.0% NaCl) intake in young Dahl/Rapp salt-sensitive (SS/Jr) and salt-resistant (SR/Jr) rats. Using NG-monomethyl-L-arginine (L-NMMA) as a probe for NO production in vivo, we found that increasing dietary sodium chloride increased NO activity in salt-resistant rats, but not in salt-sensitive rats. Exogenous L-arginine, the substrate for NO synthesis, decreased blood pressure to normotensive levels in salt-sensitive rats made hypertensive for 2 wk from 8.0% NaCl chow. D-arginine had no effect on blood pressure of these rats and L-arginine did not change blood pressure of salt-resistant rats. Intraperitoneal injections of L-arginine and its precursor, L-citrulline, and oral L-arginine, but not D-arginine, prevented the increase in blood pressure in salt-sensitive rats on the high salt chow over 2 wk of observation. In contrast, L-arginine did not alter the development of hypertension in spontaneously hypertensive rats. Mean urinary cGMP levels were higher in salt-sensitive rats on oral L-arginine than salt-sensitive rats on D-arginine. Infusion of L-NMMA acutely decreased, whereas intravenous L-arginine rapidly increased, urinary cGMP in both groups. L-arginine and L-citrulline increased production of NO and prevented salt-sensitive hypertension in Dahl/Rapp rats.
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Cited by
The L-Arginine-Nitric Oxide Pathway
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Nitric oxide as a secretory product of mammalian cells
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Cardioprotection and lifespan extension by the natural polyamine spermidine
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Subtle Acquired Renal Injury as a Mechanism of Salt-Sensitive Hypertension
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Endothelium-derived nitric oxide and vascular physiology and pathology
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Metadata
- Authors
- Chen, P. Y., & Sanders, P. W.
- Venue
- Journal of Clinical Investigation
- Published
- 1991-11-01
- Volume
- 88
- Issue
- 5
- Pages
- 1559-1567
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2040203372
- Cited by
- 450
- References
- 27
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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