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Cited by 659

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome.

Open access
Gregory, T J, Longmore, W J, Moxley, M A, Whitsett, J A, Reed, C R, Fowler, A A, Hudson, L D, Maunder, R J, Crim, C, Hyers, T M·1991·Journal of Clinical Investigation
DOI 10.1172/jci115523
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Abstract

Acute Respiratory Distress Syndrome (ARDS) is characterized by lung injury and damage to the alveolar type II cells. This study sought to determine if endogenous surfactant is altered in ARDS. Bronchoalveolar lavage was performed in patients at-risk to develop ARDS (AR, n = 20), with ARDS (A, n = 66) and in normal subjects (N, n = 29). The crude surfactant pellet was analyzed for total phospholipids (PL), individual phospholipids, SP-A, SP-B, and minimum surface tension (STmin). PL was decreased in both AR and A (3.48 +/- 0.61 and 2.47 +/- 0.40 mumol/ml, respectively) compared to N (7.99 +/- 0.60 mumol/ml). Phosphatidylcholine was decreased in A (62.64 +/- 2.20% PL) compared to N (76.27 +/- 2.05% PL). Phosphatidylglycerol was 11.58 +/- 1.21% PL in N and was decreased to 6.48 +/- 1.43% PL in A. SP-A was 123.64 +/- 20.66 micrograms/ml in N and was decreased to 49.28 +/- 21.68 micrograms/ml in AR and to 29.88 +/- 8.49 micrograms/ml in A. SP-B was 1.28 +/- 0.33 micrograms/ml in N and was decreased to 0.57 +/- 0.24 micrograms/ml in A. STmin was increased in AR (15.1 +/- 2.53 dyn/cm) and A (29.04 +/- 2.05 dyn/cm) compared to N (7.44 +/- 1.61 dyn/cm). These data demonstrate that the chemical composition and functional activity of surfactant is altered in ARDS. Several of these alterations also occur in AR, suggesting that these abnormalities occur early in the disease process.

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Metadata

Authors
Gregory, T. J., Longmore, W. J., Moxley, M. A., Whitsett, J. A., Reed, C. R., Fowler, A. A., Hudson, L. D., Maunder, R. J., Crim, C., & Hyers, T. M.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1991-12-01
Volume
88
Issue
6
Pages
1976-1981
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci115523
OpenAlex
W2159055946
Cited by
659
References
24
FWCI
20.54
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. https://app.cochat.ai/papers/10.1172/jci115523
The paper
Gregory, T. J., Longmore, W. J., Moxley, M. A., Whitsett, J. A., Reed, C. R., Fowler, A. A., Hudson, L. D., Maunder, R. J., Crim, C., & Hyers, T. M. (1991). Surfactant chemical composition and biophysical activity in acute respiratory distress syndrome. Journal of Clinical Investigation. https://doi.org/10.1172/jci115523

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.