Cited by 485Nitric Oxide and Endothelin EffectsImmune cells in cancerAngiogenesis and VEGF in Cancer

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Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy

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Hibbs, J B, Westenfelder, C, Taintor, R, Vavrin, Z, Kablitz, C, Baranowski, R L, Ward, J H, Menlove, R L, McMurry, M P, Kushner, J P·1992·Journal of Clinical Investigation

DOI 10.1172/jci115666PMC PMC442932

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Abstract

An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. High-dose interleukin-2 (IL-2) therapy is known to induce the same cytokines in patients with advanced cancer. Therefore, we examined renal cell carcinoma (RCC; n = 5) and malignant melanoma (MM; n = 7) patients for evidence of cytokine-inducible NO synthesis. Activity of this pathway was evaluated by measuring serum and urine nitrate (the stable degradation product of NO) during IL-2 therapy. IL-2 administration caused a striking increase in NO generation as reflected by serum nitrate levels (10- and 8-fold increase [P less than 0.001, P less than 0.003] for RCC and MM patients, respectively) and 24-h urinary nitrate excretion (6.5- and 9-fold increase [both P less than 0.001] for RCC and MM patients, respectively). IL-2-induced renal dysfunction made only a minor contribution to increased serum nitrate levels. Metabolic tracer studies using L-[guanidino-15N2]arginine demonstrated that the increased nitrate production was derived from a terminal guanidino nitrogen atom of L-arginine. Our results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans.

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Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences
Cohen, P., Cohen, P., West, S. G., & Aiken, L. S. (2014) · Psychology Press eBooks · doi:10.4324/9781410606266 · Cited by 20,870
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences.
Henry, N. W., Cohen, J., & Cohen, P. R. (1977) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2064799 · Cited by 7,242
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448

Flagged first, then by citations

Show all 80 references

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Hibbs, J. B., Jr., R. R. Taintor, Z. Vavrin, D. L. Granger, J.-C. Drapier, I. J. Amber, and J. R. Lancaster, Jr. 1990. Synthesis of nitric oxide from a termi- nal guanidino nitrogen atom of L-arginine: a molecular mechanism regulating Cytokine-inducible Nitric Oxide Synthesis 875 cellular proliferation that targets intracellular iron. In Nitric Oxide from L-Argi- nine: A Bioregulatory System. S. Moncada and E. A. Higgs editors. Elsevier Science Publishers B. V. (Biomedical Division), New York. 189-223.
Anon. 1981. Nitrate, nitrite and nitrogen oxides: environmental distribu- tion and exposure of humans. In The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds, Volume 1. F. M. Peter, editor. National Academy Press, Washington, DC. 3-52.
Stoff, J. S., and D. M. Clive. 1983. Role of prostaglandins and thrombox- ane in acute renal failure. In Acute Renal Failure. B. M. Brenner and J. M. Lazarus, eds. W. B. Saunders Co., Philadelphia, pp. 157-174.

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Rees, D. D. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46816-6_7 · Cited by 7
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Geller, D. A. (1993) · Archives of Surgery · doi:10.1001/archsurg.1993.01420230040006 · Cited by 6
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Shahidi, H., & Kilbourn, R. G. (1998) · Cancer and Metastasis Reviews · doi:10.1023/a:1005964907344 · Cited by 7
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Retterstøl, L., Lyberg, T., Aspelin, T., & Berg, K. (2006) · Twin Research and Human Genetics · doi:10.1375/183242706776382464 · Cited by 6
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Anstey, N. M., Weinberg, J. B., & Granger, D. L. (2002) · Springer eBooks · doi:10.1007/0-306-46816-6_15 · Cited by 6
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Millar, C. G. M., & Thiemermann, C. (1997) · Springer eBooks · doi:10.1007/978-1-4615-6039-5_14 · Cited by 6
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Brussel, T. V., & Meyer, J. (1995) · Critical Care Medicine · doi:10.1097/00003246-199502000-00031 · Cited by 5
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Porta, C., Buggia, I., Bonomi, I., Gugliotta, L., Vianelli, N., Centurioni, R., & Bobbio-Pallavicini, E. (1996) · Hematology · doi:10.1080/10245332.1996.11746310 · Cited by 5
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Authors: Hibbs, J. B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., & Kushner, J. P.
Affiliations: Veterans Health Administration (US)
University of Utah (US)
ORCID: Westenfelder, C
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1992-03-01
Volume: 89
Issue: 3
Pages: 867-877
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115666
PMC: PMC442932
OpenAlex: W2120872446
Cited by: 485
References: 80
Citations by year: 2026: 3 · 2025: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 10 · 2014: 7 · 2013: 4 · 2012: 2
FWCI: 36.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
National Institutes of Health
National Cancer Institute (CA42014, P30CA042014)
National Center for Research Resources (RR 00064)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: nitric oxide production, L-arginine, interleukin-2 therapy, interferon-gamma, TNF-α, interleukin-1, nitrate, urinary nitrate excretion, renal cell carcinoma, melanoma, renal dysfunction, arginine metabolism
MeSH terms: Adult, Arginine, Carcinoma, Renal Cell, Female, Humans, Interferon-gamma, Interleukin-2, Kidney Neoplasms, Kidney Tubules, Male, Melanoma, Middle Aged, Nitric Oxide, Vascular Resistance

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Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy

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