Cited by 485Nitric Oxide and Endothelin EffectsImmune cells in cancerAngiogenesis and VEGF in Cancer

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Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy

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Hibbs, J B, Westenfelder, C, Taintor, R, Vavrin, Z, Kablitz, C, Baranowski, R L, Ward, J H, Menlove, R L, McMurry, M P, Kushner, J P·1992·Journal of Clinical Investigation

DOI 10.1172/jci115666PMC PMC442932

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Abstract

An interferon-gamma, tumor necrosis factor, and interleukin-1-inducible, high-output pathway synthesizing nitric oxide (NO) from L-arginine was recently identified in rodents. High-dose interleukin-2 (IL-2) therapy is known to induce the same cytokines in patients with advanced cancer. Therefore, we examined renal cell carcinoma (RCC; n = 5) and malignant melanoma (MM; n = 7) patients for evidence of cytokine-inducible NO synthesis. Activity of this pathway was evaluated by measuring serum and urine nitrate (the stable degradation product of NO) during IL-2 therapy. IL-2 administration caused a striking increase in NO generation as reflected by serum nitrate levels (10- and 8-fold increase [P less than 0.001, P less than 0.003] for RCC and MM patients, respectively) and 24-h urinary nitrate excretion (6.5- and 9-fold increase [both P less than 0.001] for RCC and MM patients, respectively). IL-2-induced renal dysfunction made only a minor contribution to increased serum nitrate levels. Metabolic tracer studies using L-[guanidino-15N2]arginine demonstrated that the increased nitrate production was derived from a terminal guanidino nitrogen atom of L-arginine. Our results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans.

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Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences
Cohen, P., Cohen, P., West, S. G., & Aiken, L. S. (2014) · Psychology Press eBooks · doi:10.4324/9781410606266 · Cited by 20,870
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences.
Henry, N. W., Cohen, J., & Cohen, P. R. (1977) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2064799 · Cited by 7,242
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840
Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain
Garthwaite, J., Charles, S. L., & Chess‐Williams, R. (1988) · Nature · doi:10.1038/336385a0 · Cited by 2,540
Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia
Tracey, K. J., Fong, Y., Hesse, D. G., Manogue, K. R., Lee, A. T., Kuo, G. C., Lowry, S. F., & Cerami, A. (1987) · Nature · doi:10.1038/330662a0 · Cited by 2,448

Flagged first, then by citations

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Hibbs, J. B., Jr., R. R. Taintor, Z. Vavrin, D. L. Granger, J.-C. Drapier, I. J. Amber, and J. R. Lancaster, Jr. 1990. Synthesis of nitric oxide from a termi- nal guanidino nitrogen atom of L-arginine: a molecular mechanism regulating Cytokine-inducible Nitric Oxide Synthesis 875 cellular proliferation that targets intracellular iron. In Nitric Oxide from L-Argi- nine: A Bioregulatory System. S. Moncada and E. A. Higgs editors. Elsevier Science Publishers B. V. (Biomedical Division), New York. 189-223.
Anon. 1981. Nitrate, nitrite and nitrogen oxides: environmental distribu- tion and exposure of humans. In The Health Effects of Nitrate, Nitrite, and N-Nitroso Compounds, Volume 1. F. M. Peter, editor. National Academy Press, Washington, DC. 3-52.
Stoff, J. S., and D. M. Clive. 1983. Role of prostaglandins and thrombox- ane in acute renal failure. In Acute Renal Failure. B. M. Brenner and J. M. Lazarus, eds. W. B. Saunders Co., Philadelphia, pp. 157-174.

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ENVOLVIMENTO DA GUANILATO CICLASE SOLÚVEL E DE CANAIS DE POTÁSSIO SENSÍVEIS AO CÁLCIO NA HIPORRESPONSIVIDADE DE LONGA DURAÇÃO À FENILEFRINA INDUZIDA PELO ÓXIDO NÍTRICO NA MUSCULATURA LISA VASCULAR
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Direktor, Ä., & Hofbeck, M. (2007)
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Literature
(2004) · Wiley eBooks · doi:10.1002/9783527619610.refs
Pathogenetic Predictors of Complications of the New Coronavirus Infection SARS-COV-2
Chepur, S. V., Nn, P., Chubar, O. V., Сергеевна, Б. Л., Litvinenko, I., Tjunin, M. A., Mjasnikova, I. A., & Пугач, В. А. (2025) · Biology Bulletin Reviews · doi:10.1134/s2079086425600110
NOS2 and COX2 impact the spatial landscape of CD8+ T cells in ER-breast cancer, providing novel mechanistic insight that drives tumor progression and poor survival
Ridnour, L. A., Cheng, R. Y. S., Heinz, W. F., Coutinho, L. L., Palmieri, E. M., Rangel, M. C., Anderson, S. K., McVicar, D. W., Hewitt, S. M., Wong, S. T. C., et al. (2026) · Redox Biology · doi:10.1016/j.redox.2026.104189
iNOS is a key mediator of anti-PD-1 melanoma therapy response
Nguyen, Q. T., Kim, Y. W., Le, T. H. N., Garg†, S. K., Balkaran, V., Bhathivi, T., Chamizo, A., Dukes, C. W., Ward, K., Brohl, A. S., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1837275
Efeito do L-Name na expressão de iNOS, MPO e na perda óssea alveolar em ratos diabéticos com periodontite experimental
Gomes, D. A. S. (2009) · Americanae (AECID Library)
Clinical Aspects of Nitric Oxide (NO⋅) Blockade with Pyridoxylated-Hemoglobin Polyoxyethylene Conjugate
Kilbourn, R. G., & DeAngelo, J. D. (1999) · Springer eBooks · doi:10.1007/978-3-642-58630-9_3
Antisense Inhibition of Inducible Nitric Oxide Synthase Expression - Does it make Sense?
Hemmrich, K. (2005) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver

Authors: Hibbs, J. B., Westenfelder, C., Taintor, R., Vavrin, Z., Kablitz, C., Baranowski, R. L., Ward, J. H., Menlove, R. L., McMurry, M. P., & Kushner, J. P.
Affiliations: Veterans Health Administration (US)
University of Utah (US)
ORCID: Westenfelder, C
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1992-03-01
Volume: 89
Issue: 3
Pages: 867-877
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115666
PMC: PMC442932
OpenAlex: W2120872446
Cited by: 485
References: 80
Citations by year: 2026: 3 · 2025: 1 · 2023: 4 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 5 · 2016: 1 · 2015: 10 · 2014: 7 · 2013: 4 · 2012: 2
FWCI: 36.14
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: U.S. Department of Veterans Affairs
American Heart Association
National Institutes of Health
National Cancer Institute (CA42014, P30CA042014)
National Center for Research Resources (RR 00064)
Topics: Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: nitric oxide production, L-arginine, interleukin-2 therapy, interferon-gamma, TNF-α, interleukin-1, nitrate, urinary nitrate excretion, renal cell carcinoma, melanoma, renal dysfunction, arginine metabolism
MeSH terms: Adult, Arginine, Carcinoma, Renal Cell, Female, Humans, Interferon-gamma, Interleukin-2, Kidney Neoplasms, Kidney Tubules, Male, Melanoma, Middle Aged, Nitric Oxide, Vascular Resistance

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Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy

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