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Waking genioglossal electromyogram in sleep apnea patients versus normal controls (a neuromuscular compensatory mechanism).
Open accessAbstract
Pharyngeal collapse in obstructive sleep apnea patients is likely a product of a sleep-related decrement in pharyngeal dilator muscle activity superimposed upon abnormal airway anatomy. We postulate that during wakefulness, increased pharyngeal dilator muscle activity in apnea patients compensates for diminished airway size thus maintaining patency. We studied the waking genioglossus (GG) electromyogram (EMG) activity in 11 OSA patients and 14 age-matched controls to determine if GG activity is higher in the awake state in apnea patients than controls. To make this determination, we developed a reproducible methodology whereby true maximal GG EMG could be defined and thus basal activity quantitated as a percentage of this maximal value. Therefore, direct comparisons of basal activity between individuals was possible. We observed apnea patients to have significantly greater basal genioglossal activity compared to controls (40.6 +/- 5.6% vs. 12.7 +/- 1.7% of maximum). This difference persisted when size-matched subsets were compared. This augmented GG activity in apnea patients could be reduced with positive airway pressure. We speculate that this neuromuscular compensation present during wakefulness in apnea patients may be lost during sleep leading to airway collapse.
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“Obesity, specifically central adiposity, increases pharyngeal collapsibility that causes recurrent episodes of UA obstruction in sleep apnea through both mechanical and neuromuscular effects.199–203”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [201]
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“Through protective UA dilator muscle reflexes, the activity of the muscles is increased during wakefulness in OSA compared to matched controls.201”
From International Consensus Statement on Obstructive Sleep Apnea (2023) · cites this paper as [201]
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Citations
Cites
Statistical Methods for Rates and Proportions
Fleiss, J. L., Levin, B., & Paik, M. C. (2003) · Wiley Series in Probability and Statistics · doi:10.1002/0471445428 · Cited by 18,646
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Statistical Methods for Rates and Proportions.
Everitt, B. S., & Fleiss, J. L. (1981) · Biometrics · doi:10.2307/2530193 · Cited by 9,034
Hobson, J. A. (1969) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(69)90021-2 · Cited by 5,215
Pathogenesis of upper airway occlusion during sleep
Remmers, J. E., deGroot, W. J., Sauerland, E. K., & Anch, A. M. (1978) · Journal of Applied Physiology · doi:10.1152/jappl.1978.44.6.931 · Cited by 1,883
The human tongue during sleep: Electromyographic activity of the genioglossus muscle
Sauerland, E. K., & Harper, R. M. (1976) · Experimental Neurology · doi:10.1016/0014-4886(76)90061-3 · Cited by 439
Fluoroscopic and Computed Tomographic Features of the Pharyngeal Airway in Obstructive Sleep Apnea
Suratt, P. M., Dee, P., Atkinson, R. L., Armstrong, P., & Wilhoit, S. C. (1983) · American Review of Respiratory Disease · doi:10.1164/arrd.1983.127.4.487 · Cited by 375
Hypercapnic ventilatory response in sleeping adults.
Douglas, N. J., White, D. P., Weil, J. V., Pickett, C. K., & Zwillich, C. W. (1982) · PubMed · doi:10.1164/arrd.1982.126.5.758 · Cited by 371
Self-citationPharyngeal Size in Snorers, Nonsnorers, and Patients with Obstructive Sleep Apnea
Bradley, T. D., Brown, I. G., Grossman, R. F., Zamel, N., Martinez, D., Phillipson, E. A., & Hoffstein, V. (1986) · New England Journal of Medicine · doi:10.1056/nejm198611203152105 · Cited by 330
Hypoxic ventilatory response decreases during sleep in normal men.
Douglas, N. J., White, D. P., Weil, J. V., Pickett, C. K., Martin, R. J., Hudgel, D. W., & Zwillich, C. W. (1982) · PubMed · doi:10.1164/arrd.1982.125.3.286 · Cited by 324
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
ATS/ERS Statement on Respiratory Muscle Testing
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.166.4.518 · Cited by 2,940
Pathophysiology of Sleep Apnea
Dempsey, J. A., Veasey, S. C., Morgan, B. J., & O'Donnell, C. P. (2010) · Physiological Reviews · doi:10.1152/physrev.00043.2008 · Cited by 2,243
Adult obstructive sleep apnoea
Jordan, A. S., McSharry, D. G., & Malhotra, A. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60734-5 · Cited by 1,735
Malhotra, A., & White, D. P. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09464-3 · Cited by 1,260
Self-citationDefining Phenotypic Causes of Obstructive Sleep Apnea. Identification of Novel Therapeutic Targets
Eckert, D. J., White, D. P., Jordan, A. S., Malhotra, A., & Wellman, A. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201303-0448oc · Cited by 1,173
Self-citationObesity and Obstructive Sleep Apnea: Pathogenic Mechanisms and Therapeutic Approaches
Schwartz, A. R., Patil, S. P., Laffan, A. M., Polotsky, V., Schneider, H., & Smith, P. L. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200708-137mg · Cited by 730
Pathophysiology of Adult Obstructive Sleep Apnea
Eckert, D. J., & Malhotra, A. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200707-114mg · Cited by 719
Pathogenesis of Obstructive and Central Sleep Apnea
White, D. P. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1631so · Cited by 698
Self-citationPatil, S. P., Schneider, H., Schwartz, A. R., & Smith, P. L. (2007) · CHEST Journal · doi:10.1378/chest.07-0040 · Cited by 567
Oral Appliances for the Treatment of Snoring and Obstructive Sleep Apnea: A Review
Schmidt-Nowara, W. W., Lowe, A. A., Wiegand, L. A., CARTWRIGHT, R. D., Perez-Guerra, F., & Menn, S. J. (1995) · SLEEP · doi:10.1093/sleep/18.6.501 · Cited by 541
Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects
Isono, S., Remmers, J. E., Tanaka, A., Sho, Y., Sato, J., & Nishino, T. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.4.1319 · Cited by 535
Schwab, R. J., Gefter, W. B., Hoffman, E. A., Gupta, K. B., & Pack, A. I. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.5.1385 · Cited by 505
Caples, S. M., Gami, A. S., & Somers, V. K. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-3-200502010-00010 · Cited by 465
Gender differences in obstructive sleep apnea and treatment implications
Lin, C. M., Davidson, T. M., & Ancoli‐Israel, S. (2008) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2007.11.003 · Cited by 477
Pharyngeal Fat in Obstructive Sleep Apnea
Shelton, K. E., Woodson, H., Gay, S., & Suratt, P. M. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.2.462 · Cited by 458
The Male Predisposition to Pharyngeal Collapse: Importance of Airway Length
Malhotra, A., Huang, Y., Fogel, R. B., Pillar, G., Edwards, J. K., Kikinis, R., Loring, S. H., & White, D. P. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2112072 · Cited by 441
Self-citationPathophysiology of Upper Airway Obstruction: a Developmental Perspective
Arens, R., & Marcus, C. L. (2004) · SLEEP · doi:10.1093/sleep/27.5.997 · Cited by 432
Tongue Fat and its Relationship to Obstructive Sleep Apnea
Kim, A. M., Keenan, B. T., Jackson, N., Chan, E. L., Staley, B., Poptani, H., Torigian, D. A., Pack, A. I., & Schwab, R. J. (2014) · Sleep · doi:10.5665/sleep.4072 · Cited by 394
Non-CPAP therapies in obstructive sleep apnoea
Randerath, W. J., Verbraecken, J., Andreas, S., Bettega, G., Boudewyns, A., Hamans, E., Jalbert, F., Paoli, J. R., Sanner, B., Smith, I., et al. (2011) · European Respiratory Journal · doi:10.1183/09031936.00099710 · Cited by 388
Mortimore, I. L., Marshall, I., WRAITH, P. K., Sellar, R. J., & Douglas, N. J. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.1.9703018 · Cited by 378
Upper airway muscle activity in normal women: influence of hormonal status
Popovic, R. M., & White, D. P. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.3.1055 · Cited by 377
Self-citationEckert, D. J., Owens, R. L., Kehlmann, G. B., Wellman, A., Rahangdale, S., Yim-Yeh, S., White, D. P., & Malhotra, A. (2011) · Clinical Science · doi:10.1042/cs20100588 · Cited by 367
Self-citationInternational Consensus Statement on Obstructive Sleep Apnea
Chang, J. L., Goldberg, A. N., Alt, J. A., Mohammed, A., Ashbrook, L., Auckley, D., Ayappa, I., Bakhtiar, H., Barrera, J. E., Bartley, B. L., et al. (2023) · International Forum of Allergy & Rhinology · doi:10.1002/alr.23079 · Cited by 350
Obesity and obstructive sleep apnea
Gami, A. S., Caples, S. M., & Somers, V. K. (2003) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(03)00069-0 · Cited by 340
The upper airway in sleep: physiology of the pharynx
Ayappa, I. A., & Rapoport, D. M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0238 · Cited by 346
Aging Influences on Pharyngeal Anatomy and Physiology: The Predisposition to Pharyngeal Collapse
Malhotra, A., Huang, Y., Fogel, R., Lazic, S., Pillar, G., Jakab, M., Kikinis, R., & White, D. P. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.01.077 · Cited by 351
Self-citationThe upper airway during anaesthesia
Hillman, D. R., Platt, P. R., & Eastwood, P. R. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg126 · Cited by 328
Salman, L. A., Shulman, R., & Cohen, J. B. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-1257-y · Cited by 345
Obstructive sleep apnea syndrome
Mannarino, M. R., Filippo, F. D., & Pirro, M. (2012) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2012.05.013 · Cited by 338
Neuromechanical control of upper airway patency during sleep
Patil, S. P., Schneider, H., Marx, J. J., Gladmon, E., Schwartz, A. R., & Smith, P. L. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00282.2006 · Cited by 295
Sleep {middle dot} 2: Pathophysiology of obstructive sleep apnoea/hypopnoea syndrome
Fogel, R. (2004) · Thorax · doi:10.1136/thorax.2003.015859 · Cited by 292
Kato, J., Isono, S., Tanaka, A., Watanabe, T., Araki, D., Tanzawa, H., & Nishino, T. (2000) · CHEST Journal · doi:10.1378/chest.117.4.1065 · Cited by 286
The Influence of Aging on Pharyngeal Collapsibility During Sleep
Eikermann, M., Jordan, A. S., Chamberlin, N. L., Gautam, S., Wellman, A., Lo, Y.-L., White, D. P., & Malhotra, A. (2007) · CHEST Journal · doi:10.1378/chest.06-2653 · Cited by 292
Self-citationCrossing the apnoeic threshold: causes and consequences
Dempsey, J. A. (2004) · Experimental Physiology · doi:10.1113/expphysiol.2004.028985 · Cited by 282
Patel, S. R. (2019) · Annals of Internal Medicine · doi:10.7326/aitc201912030 · Cited by 276
Supine position related obstructive sleep apnea in adults: Pathogenesis and treatment
Joosten, S. A., O’Driscoll, D. M., Berger, P. J., & Hamilton, G. S. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.01.005 · Cited by 266
Contributions of Upper Airway Mechanics and Control Mechanisms to Severity of Obstructive Apnea
Younes, M. K. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200302-201oc · Cited by 258
Endocrine Aspects of Obstructive Sleep Apnea
Attal, P. D., & Chanson, P. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1912 · Cited by 258
Ryan, C. F., Love, L. L., Peat, D., Fleetham, J. A., & Lowe, A. A. (1999) · Thorax · doi:10.1136/thx.54.11.972 · Cited by 235
Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders
Younes, M. K. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90408.2008 · Cited by 225
The Predisposition to Inspiratory Upper Airway Collapse during Partial Neuromuscular Blockade
Eikermann, M., VOGT, F. M., Herbstreit, F., Vahid-Dastgerdi, M., Zenge, M. O., Ochterbeck, C., de Greiff, A., & Peters, J. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200512-1862oc · Cited by 213
Influence of Sleep on Genioglossus Muscle Activation by Negative Pressure in Normal Men
Wheatley, J. R., Mezzanotte, W. S., Tangel, D. J., & White, D. P. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.3.597 · Cited by 211
Self-citationGenioglossal Activation in Patients with Obstructive Sleep Apnea versus Control Subjects
Fogel, R., Malhotra, A., Pillar, G., EDWARDS, J. K., Beauregard, J., Shea, S. A., & White, D. P. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.11.2102048 · Cited by 207
Self-citationUpper Airway Collapsibility is Associated with Obesity and Hyoid Position
Genta, P. R., Schorr, F., Eckert, D. J., Gebrim, E., Kayamori, F., Moriya, H. T., Malhotra, A., & Lorenzi-Filho, G. (2014) · Sleep · doi:10.5665/sleep.4078 · Cited by 203
Obstructive Sleep Apnea of Obese Adults
Isono, S., Warner, D. S., & Warner, M. A. A. (2009) · Anesthesiology · doi:10.1097/aln.0b013e31819c74be · Cited by 209
Schwab, R. J. (1998) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70430-5 · Cited by 199
Pathophysiology of childhood obstructive sleep apnea: current concepts
Marcus, C. L. (2000) · Respiration Physiology · doi:10.1016/s0034-5687(99)00109-7 · Cited by 198
Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms
Jordan, A. S., & McEvoy, R. D. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0260 · Cited by 195
Obstructive sleep apnea syndrome in children: Epidemiology, pathophysiology, diagnosis and sequelae
Chang, S. J., & Chae, K. Y. (2010) · Korean Journal of Pediatrics · doi:10.3345/kjp.2010.53.10.863 · Cited by 195
Fogel, R., Trinder, J. C., White, D. P., Malhotra, A., Raneri, J. K., Schory, K., Kleverlaan, D., & Pierce, R. J. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.083659 · Cited by 196
Self-citationStanchina, M. L., Malhotra, A., Fogel, R., Trinder, J. C., EDWARDS, J. K., Schory, K., & White, D. P. (2003) · SLEEP · doi:10.1093/sleep/26.7.851 · Cited by 195
Self-citationThe Hypotonic Upper Airway in Obstructive Sleep Apnea: Role of Structures and Neuromuscular Activity
Schwartz, A. R., O'Donnell, C. P., Baron, J. J., Schubert, N. M., Alam, D. S., Samadi, S., & SMITH, P. L. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.4.9706067 · Cited by 192
Airway Mechanics and Ventilation in Response to Resistive Loading during Sleep
PILLAR, G., MALHOTRA, A., FOGEL, R., BEAUREGARD, J., SCHNALL, R., & WHITE, D. P. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.162.5.2003131 · Cited by 188
Self-citationObstructive sleep apnea and the hyoid: A revised surgical procedure
RILEY, R., POWELL, N., & GUILLEMINAULT, C. (1994) · Otolaryngology - Head and Neck Surgery · doi:10.1016/s0194-5998(94)70557-7 · Cited by 191
Advances in Sleep-disordered Breathing
Pack, A. I. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200509-1478oe · Cited by 192
Mayer, P., Pépin, J., Bettega, G., Veale, D., Ferretti, G., Deschaux, C., & Levy, P. A. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09091801 · Cited by 186
Activity of respiratory pump and upper airway muscles during sleep onset
Worsnop, C., Kay, A., Pierce, R. J., Kim, Y., & Trinder, J. C. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.3.908 · Cited by 173
Eckert, D. J., Malhotra, A., & Jordan, A. S. (2008) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2008.02.003 · Cited by 183
Endotypes and phenotypes in obstructive sleep apnea
Malhotra, A., Mesarwi, O. A., Pépin, J., & Owens, R. L. (2020) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000724 · Cited by 178
Sériès, F., Côt́e, C. H., Simoneau, J. A., Gélinas, Y., Pierre, S. S., Leclerc, J., Ferland, R., & Marc, I. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117640 · Cited by 168
Upper Airway Dynamic Responses in Children with the Obstructive Sleep Apnea Syndrome
Marcus, C. L., Katz, E. S., Lutz, J., Black, C. A., Galster, P., & Carson, K. A. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000147565.74947.14 · Cited by 168
Upper Airway Shape: Is It Important in the Pathogenesis of Obstructive Sleep Apnea?
Leiter, J. C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.3.8630569 · Cited by 166
Upper airway neuromuscular compensation during sleep is defective in obstructive sleep apnea
McGinley, B. M., Schwartz, A. R., Schneider, H., Kirkness, J. P., Smith, P. L., & Patil, S. P. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01214.2007 · Cited by 164
Influence of Gender on Waking Genioglossal Electromyogram and Upper Airway Resistance
Popovic, R. M., & White, D. P. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.152.2.7633734 · Cited by 163
Self-citationPack, A. I. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2401008 · Cited by 163
The effect of body posture on sleep-related breathing disorders: facts and therapeutic implications
Oksenberg, A., & Silverberg, D. S. (1998) · Sleep Medicine Reviews · doi:10.1016/s1087-0792(98)90018-1 · Cited by 163
Pathogenesis of obstructive sleep apnoea/hypopnoea syndrome
Douglas, N. J., & Polo, O. J. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92088-5 · Cited by 162
Sleep-related breathing disorder.2. Pathophysiology of obstructive sleep apnoea.
White, D. P. (1995) · Thorax · doi:10.1136/thx.50.7.797 · Cited by 157
Self-citationTonic and Phasic Respiratory Drives to Human Genioglossus Motoneurons During Breathing
Saboisky, J. P., Butler, J. E., Fogel, R., Taylor, J. L., Trinder, J. A., White, D. P., & Gandevia, S. C. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00940.2005 · Cited by 156
Self-citationEckert, D. J., Malhotra, A., Wellman, A., & White, D. P. (2014) · SLEEP · doi:10.5665/sleep.3596 · Cited by 154
Self-citationNatural head posture, upper airway morphology and obstructive sleep apnoea severity in adults
Ozbek, M. (1998) · European Journal of Orthodontics · doi:10.1093/ejo/20.2.133 · Cited by 155
Craniofacial abnormalities in obstructive sleep apnoea: Implications for treatment
CISTULLI, P. A. (1996) · Respirology · doi:10.1111/j.1440-1843.1996.tb00028.x · Cited by 153
The Effects of Serotonin Antagonists in an Animal Model of Sleep-Disordered Breathing
Veasey, S. C., Panckeri, K. A., Hoffman, E. A., Pack, A. I., & Hendricks, J. C. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.2.8564132 · Cited by 152
Anatomical Balance of the Upper Airway and Obstructive Sleep Apnea
Tsuiki, S., Isono, S., Ishikawa, T., Yamashiro, Y., Tatsumi, K., & Nishino, T. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318173f103 · Cited by 154
Determinants of Ventilatory Instability in Obstructive Sleep Apnea: Inherent or Acquired?
Loewen, A., Ostrowski, M., Laprairie, J., Atkar, R., Gnitecki, J., Hanly, P., & Younes, M. (2009) · Sleep · doi:10.1093/sleep/32.10.1355 · Cited by 149
Pharyngeal motor control and the pathogenesis of obstructive sleep apnea
Jordan, A. S., & White, D. P. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.07.009 · Cited by 151
Self-citationThe Pathogenesis of Obstructive Sleep Apnea
White, D. P. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0317oe · Cited by 144
Self-citationPostoperative Respiratory Muscle Dysfunction
Sasaki, N., Meyer, M. J., & Eikermann, M. (2013) · Anesthesiology · doi:10.1097/aln.0b013e318288834f · Cited by 142
White, D. P., & Younes, M. K. (2012) · Comprehensive physiology · doi:10.1002/cphy.c110064 · Cited by 155
Self-citationControl of Upper Airway Motoneurons During REM Sleep
Kubin, L. K., Davies, R. O., & Pack, A. I. (1998) · Physiology · doi:10.1152/physiologyonline.1998.13.2.91 · Cited by 137
Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans
Jordan, A. S., Wellman, A., Heinzer, R. C., Lo, Y.-L., Schory, K., Dover, L., Gautam, S., Malhotra, A., & White, D. P. (2007) · Thorax · doi:10.1136/thx.2006.070300 · Cited by 134
Self-citationMyofunctional therapy improves adherence to continuous positive airway pressure treatment
Diaféria, G. L. A., Santos‐Silva, R., Truksinas, E., Haddad, F. L. M., dos Santos, R., Bommarito, S., Gregório, L. C., Tufik, S. B., & Bittencourt, L. (2016) · Sleep And Breathing · doi:10.1007/s11325-016-1429-6 · Cited by 133
Role of Endogenous Serotonin in Modulating Genioglossus Muscle Activity in Awake and Sleeping Rats
Sood, S., Morrison, J. L., Liu, H., & Horner, R. L. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200502-258oc · Cited by 129
Christou, K., Markoulis, N., Moulas, A. N., Pastaka, C., & Gourgoulianis, K. (2003) · Sleep And Breathing · doi:10.1007/s11325-003-0105-9 · Cited by 135
Qureshi, A., Ballard, R. D., & Nelson, H. S. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.08.031 · Cited by 138
Serotonin Agonists and Antagonists in Obstructive Sleep Apnea: Therapeutic Potential
Veasey, S. C. (2003) · American Journal of Respiratory Medicine · doi:10.1007/bf03256636 · Cited by 129
Trazodone Effects on Obstructive Sleep Apnea and Non-REM Arousal Threshold
Smales, E. T., Edwards, B. A., Deyoung, P. N., McSharry, D. G., Wellman, A., Velasquez, A., Owens, R., Orr, J. E., & Malhotra, A. (2015) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201408-399oc · Cited by 127
Bilston, L. E., & Gandevia, S. C. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00539.2013 · Cited by 131
Shea, S. A., EDWARDS, J. K., & White, D. P. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00897.x · Cited by 127
Self-citationDrive to the human respiratory muscles
Butler, J. E. (2007) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2007.06.006 · Cited by 127
Sériès, F., Simoneau, S. A., Pierre, S. S., & Marc, I. (1996) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.153.6.8665048 · Cited by 124
Ho, M. L., & Brass, S. D. (2011) · Neurology International · doi:10.4081/ni.2011.e15 · Cited by 133
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Self-citation
Metadata
- Authors
- Mezzanotte, W. S., Tangel, D. J., & White, D. P.
- Affiliations
- Denver VA Medical Center (US)
- National Jewish Health (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1992-05-01
- Volume
- 89
- Issue
- 5
- Pages
- 1571-1579
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC443031
- OpenAlex
- W2139404323
- Cited by
- 769
- References
- 56
- Citations by year
- 2026: 18 · 2025: 9 · 2024: 25 · 2023: 23 · 2022: 18 · 2021: 14 · 2020: 23 · 2019: 32 · 2018: 33 · 2017: 23 · 2016: 21 · 2015: 30 · 2014: 44 · 2013: 22 · 2012: 26
- FWCI
- 4.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-07085, T32HL007085)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Health Professions › Speech and Hearing › Dysphagia Assessment and Management
- Keywords
- obstructive sleep apnea, genioglossus muscle, pharyngeal dilator muscles, neuromuscular compensation, pharyngeal collapse, airway patency, positive airway pressure, wakefulness
- MeSH terms
- Electromyography, Humans, Male, Pharynx, Sleep Apnea Syndromes, Wakefulness
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