The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection.
Open accessAbstract
Relaxation of the trabecular smooth muscle of the corpus cavernosum (the erectile tissue) of the penis is mediated by nitric oxide released by the nerves and endothelium. We have investigated the physiological role of oxygen tension in the regulation of trabecular smooth muscle tone. In human subjects, measurement of intracavernosal PO2 in blood drawn from corpus cavernosum in the flaccid state was comparable to that of venous blood (25-43 mmHg). Vasodilatation of the resistance arteries and trabecular smooth muscle relaxation by intracavernosal injection of papaverine and phentolamine caused oxygen tension to rise rapidly to arterial levels (PO2 approximately 100 mmHg). Isolated human and rabbit corpus cavernosum tissue strips in organ baths, exposed to arterial-like PO2 relaxed to the endothelium-dependent dilator acetylcholine and to electrical stimulation of the autonomic dilator nerves. These nitric oxide-mediated responses were progressively inhibited as a function of decreasing PO2 to levels measured in the flaccid penis. Reverting to normoxic conditions readily restored endothelium-dependent and neurogenic relaxation. Relaxation to exogenous nitric oxide was not impaired in low PO2. In rabbit corpus cavernosum, low PO2 reduced basal levels of cGMP and prevented cGMP accumulation induced by stimulation of dilator nerves. Furthermore, low PO2 inhibited nitric oxide synthase activity in corpus cavernosum cytosol. It is concluded that physiological concentrations of oxygen modulate penile erection by regulating nitric oxide synthesis in corpus cavernosum tissue.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Rajfer, J., Aronson, W. J., Bush, P. A., Dorey, F. J., & Ignarro, L. J. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201093260203 · Cited by 1,006
(1991) · doi:10.1172/jci115266 · Cited by 429
Self-citation
Cited by
Montorsi, F., Luigi, G. G., Strambi, L. F., Da Pozzo, L. F., Nava, L., Barbieri, L., Rigatti, P., Pizzini, G., & Miani, A. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)64227-7 · Cited by 547
THE EPIDEMIOLOGY AND PATHOPHYSIOLOGY OF ERECTILE DYSFUNCTION
MELMAN, A., & GINGELL, J. C. (1999) · Journal of Urology · doi:10.1016/s0022-5347(01)62045-7 · Cited by 308
Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis
Jantsch, J., & Schödel, J. (2015) · Immunobiology · doi:10.1016/j.imbio.2014.09.009 · Cited by 46
Metadata
- Authors
- Kim, N., Vardi, Y., Padma-Nathan, H., Daley, J., Goldstein, I., & Saenz de Tejada, I.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-02-01
- Volume
- 91
- Issue
- 2
- Pages
- 437-442
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2118698512
- Cited by
- 285
- References
- 3
- FWCI
- 12.02
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. https://app.cochat.ai/papers/10.1172/jci116220
- The paper
- Kim, N., Vardi, Y., Padma-Nathan, H., Daley, J., Goldstein, I., & Saenz de Tejada, I. (1993). Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. Journal of Clinical Investigation. https://doi.org/10.1172/jci116220
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
