Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis
Open accessAbstract
The impact of tissue oxygenation and hypoxia on immune cells has been recognized as a major determinant of host defense and tissue homeostasis. In this review, we will summarize the available data on tissue oxygenation in inflamed and infected tissue and the effect of low tissue oxygenation on myeloid cell function. Furthermore, we will highlight effects of the master regulators of the cellular hypoxic response, hypoxia-inducible transcription factors (HIF), in myeloid cells in antimicrobial defense and tissue homeostasis.
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Tissue hypoxia that may result from anemia of chronic disease is sensed by HIF in various cell types including macrophages and dendritic cells.
“The tissue hypoxia that may results from ACD is sensed by HIF in various cell types including macrophages and dendritic cells (Jantsch and Schodel, 2015;Zinkernagel et al., 2007).”
From Iron in infection and immunity (2020) · cites this paper as Jantsch and Schodel, 2015
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“HIF-la expression can also occur in an oxygen-independent manner in myeloid cells fighting pathogens, driving metabolic reprogramming to modulate oxygen consumption and modulating innate immunity (Jantsch and Schödel, 2015; Devraj et al., 2017; Stothers et al., 2018; Knight and Stanley, 2019).”
BackgroundMechanisms controlling bacterial infection in myeloid cells under hypoxic conditions
Hayek, I., Schatz, V., Bogdan, C., Jantsch, J., & Lührmann, A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03684-8 · Cited by 24 · see citing works
Self-citationClayton, S. A., Lockwood, C., O’Neil, J. D., Daley, K. K., Hain, S., Abdelmottaleb, D. I., Bolimowska, O. O., Tennant, D. A., & Clark, A. R. (2023) · Discovery Immunology · doi:10.1093/discim/kyad027 · Cited by 24 · see citing works
The Impact of Oxygen on Bacterial Enteric Pathogens
Wallace, N., Zani, A., Abrams, E. A., & Sun, Y. (2016) · Advances in applied microbiology · doi:10.1016/bs.aambs.2016.04.002 · Cited by 22 · see citing works
Oxygenation of the Transplanted Kidney
Rosenberger, C., & Eckardt, K. (2019) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2019.10.005 · Cited by 21 · see citing works
Hypoxia, Hypoxia-Inducible Factor-1α, and Innate Antileishmanial Immune Responses
Schatz, V., Neubert, P., Rieger, F., & Jantsch, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00216 · Cited by 21 · see citing works
“(1, 8, 9)] or infection with various pathogens such as S.”
BackgroundSelf-citationSalmonella adhesion is decreased by hypoxia due to adhesion and motility structure crosstalk
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2023) · Veterinary Research · doi:10.1186/s13567-023-01233-2 · Cited by 13 · see citing works
“Previous studies have identified oxygen as a critical resource for Salmonella infection and intestinal colonization [20, 36].”
BackgroundSaraiva, F. M. D. S., Cosentino‐Gomes, D., Inacio, J. D. F., de Almeida-Amaral, E. E., Louzada-Neto, O., Rossini, A., Nogueira, N. P. D. A., Meyer‐Fernandes, J. R., & Paes, M. C. (2022) · Pathogens · doi:10.3390/pathogens11080897 · Cited by 13 · see citing works
“Low oxygen levels are also an important aspect of infected and inflamed tissues for reactive oxygen production [16].”
BackgroundFrick, L., Hinterland, L., Renner, K., Vogl, M., Babl, N., Heckscher, S., Weigert, A., Weiß, S., Gläsner, J., Berger, R. S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.789366 · Cited by 12 · see citing works
Self-citationDetection of Coxiella burnetii in the mammary gland of a dairy goat
Bauer, B. U., Peters, M. C., Herms, L., Runge, M., Wohlsein, P., Jensen, T. K., & Ganter, M. (2024) · Veterinary Research Communications · doi:10.1007/s11259-023-10233-8 · Cited by 12 · see citing works
“Our hypothesis is supported by the detection of C. burnetii in arteriosclerotic plaques in humans, which are also considered hypoxic (Hagenaars et al. 2014; Jantsch and Schödel 2015).”
BackgroundResultRao, Z., Cao, L., Qiu, X., & Han, R. (2018) · Journal of Insect Physiology · doi:10.1016/j.jinsphys.2018.11.001 · Cited by 11 · see citing works
Multidrug Efflux Systems in Microaerobic and Anaerobic Bacteria
Xu, Z., & Yan, A. (2015) · Antibiotics · doi:10.3390/antibiotics4030379 · Cited by 11 · see citing works
“present in microaerobic and strict anaerobic niches, which represent the conditions in wounded, infected, and inflamed tissues within a human host [4].”
BackgroundLi, H., Yu, B., Lin, J., Wang, Q., Zhang, L., Liu, X., Li, C., Liu, Y., Li, C., & Zhao, G. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114286 · Cited by 8 · see citing works
Negative Impact of Hypoxia on Tryptophan 2,3-Dioxygenase Function
Elbers, F., Woite, C., Antoni, V., Stein, S. L., Funakoshi, H., Nakamura, T., Schares, G., Däubener, W., & Eller, S. K. (2016) · Mediators of Inflammation · doi:10.1155/2016/1638916 · Cited by 8 · see citing works
“It was shown by us that recombinantly expressed human TDO is able to inhibit the growth of bacteria, parasites, and viruses [4] and also infected tissue displays low oxygen levels or hypoxia [12].”
BackgroundCoxiella burnetii Affects HIF1α Accumulation and HIF1α Target Gene Expression
Hayek, I., Szperlinski, M., & Lührmann, A. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.867689 · Cited by 7 · see citing works
Ben-Cheikh, A., Bali, A., Guerfali, F. Z., Atri, C., Attia, H., & Laouini, D. (2022) · Korean Journal of Parasitology · doi:10.3347/kjp.2022.60.5.317 · Cited by 6 · see citing works
Pjanova, D., Hurmach, Y., Rudyk, M. P., Khranovska, N., Skachkova, O., Verhovcova, I., & Skivka, L. M. (2021) · Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences · doi:10.2478/prolas-2021-0050 · Cited by 6 · see citing works
Gomez, J. C., & Doerschuk, C. M. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202201-0086ed · Cited by 6 · see citing works
“Hypoxia may also alter the response of myeloid cells to bacterial and viral pathogens, perhaps distorting the balance between beneficial pathogen destruction and deleterious host-cell injury (1, 2).”
BackgroundComputational Identification of Master Regulators Influencing Trypanotolerance in Cattle
Rajavel, A., Schmitt, A. O., & Gültaş, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020562 · Cited by 4 · see citing works
“In Table 3, the top three over-represented pathways are associated with low oxygen environment and HIF accumulation due to parasitic infection [124,125] in the liver tissue of the trypanosusceptible breed Boran.”
BackgroundModulation of Innate Immunity by Hypoxia
Riboldi, E., & Sica, A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-801968-9.00004-0 · Cited by 3 · see citing works
O2-dependent incapacitation of the Salmonella pathogenicity island 1 repressor HilE
Walter, S., Schatz, V., Petzold, J., Schmidt, C., Hoffmann, S., Jantsch, J., & Gerlach, R. G. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1434254 · Cited by 2 · see citing works
“Low oxygen (O 2 ) tension is another environmental cue within the host organism (Jantsch and Schödel, 2015).”
Self-citationLenkewitz, A., Brahim, I. B., Herrmann, F., Islam, N.-A.-K., Tichá, O., & Bekeredjian‐Ding, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.15.613102 · Cited by 1 · see citing works
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631304
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631310
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631298
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631319
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631325
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631322
Grzymajło, K., Dutkiewicz, A., Czajkowska, J., Carolak, E., Aleksandrowicz, A., & Waszczuk, W. (2024) · Figshare · doi:10.6084/m9.figshare.26631301
ROLE OF HIF-1 SIGNALING PATHWAY IN CELLULAR ADAPTATION TO HYPOXIA
Borysewicz, K., Koval, I., Kubik, W., Czarnecki, B., Nowak, J., Kujawa, B., Zwoliński, B., Sukiennicki, K., Bertman, W., Kołdej, N., et al. (2025) · International Journal of Innovative Technologies in Social Science · doi:10.31435/ijitss.4(48).2025.4299
Durrani, H., Bjork, J. A., Clarke, A. B., Steinbach, J. T., & Zimmer, S. L. (2026) · Frontiers in Parasitology · doi:10.3389/fpara.2026.1823935
“Low oxygen is a signi fi cant factor in fl uencing the pathogen-host response, including that of trypanosomatids, within infected and in fl amed tissues in mammals (Jantsch and Schödel, 2015).”
- Authors
- Jantsch, J., & Schödel, J.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Jantsch, Jonathan
- Schödel, Johannes
- Venue
- Immunobiology
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 220
- Issue
- 2
- Pages
- 305-314
- ISSN
- 0171-2985 (ISSN-L)
- OpenAlex
- W2012647059
- Cited by
- 46
- References
- 174
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 9 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 3
- FWCI
- 0.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Immunobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (DFG; JA 1993/1-1 and 2-1; SFB 643/4; SCHO 1598/1-1)
- Interdisciplinary Center of Clinical Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- hypoxia, hypoxia-inducible factor, myeloid cells, tissue oxygenation, host defense, tissue homeostasis, antimicrobial defense, inflammation, infection, hypoxia response
- MeSH terms
- Animals, Hypoxia, Dendritic Cells, Granulocytes, Homeostasis, Humans, Immunity, Innate, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Oxygen Consumption, Transcription Factors, Signal Transduction, Cell Hypoxia, Disease Progression, Myeloid Cells, Hypoxia-Inducible Factor 1, Host-Pathogen Interactions
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