Cited by 46Cancer, Hypoxia, and MetabolismImmune cells in cancerImmune Response and Inflammation

Hypoxia and hypoxia-inducible factors in myeloid cell-driven host defense and tissue homeostasis

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Jantsch, Jonathan, Schödel, Johannes·2015·Immunobiology

Abstract

The impact of tissue oxygenation and hypoxia on immune cells has been recognized as a major determinant of host defense and tissue homeostasis. In this review, we will summarize the available data on tissue oxygenation in inflamed and infected tissue and the effect of low tissue oxygenation on myeloid cell function. Furthermore, we will highlight effects of the master regulators of the cellular hypoxic response, hypoxia-inducible transcription factors (HIF), in myeloid cells in antimicrobial defense and tissue homeostasis.

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Crossref · 10.1016/j.imbio.2014.09.009

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  • Tissue hypoxia that may result from anemia of chronic disease is sensed by HIF in various cell types including macrophages and dendritic cells.

    “The tissue hypoxia that may results from ACD is sensed by HIF in various cell types including macrophages and dendritic cells (Jantsch and Schodel, 2015;Zinkernagel et al., 2007).”

    From Iron in infection and immunity (2020) · cites this paper as Jantsch and Schodel, 2015

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Authors
Jantsch, J., & Schödel, J.
Affiliations
Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
Corresponding author
  • Jantsch, Jonathan
  • Schödel, Johannes
Venue
Immunobiology
Publisher
Elsevier BV
Published
2015-02
Volume
220
Issue
2
Pages
305-314
ISSN
0171-2985 (ISSN-L)
OpenAlex
W2012647059
Cited by
46
References
174
Citations by year
2026: 1 · 2025: 3 · 2024: 9 · 2023: 3 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 3
FWCI
0.33
Type
journal article
Language
en
Open access
Locations
  • Immunobiology (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft (DFG; JA 1993/1-1 and 2-1; SFB 643/4; SCHO 1598/1-1)
  • Interdisciplinary Center of Clinical Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords
hypoxia, hypoxia-inducible factor, myeloid cells, tissue oxygenation, host defense, tissue homeostasis, antimicrobial defense, inflammation, infection, hypoxia response
MeSH terms
Animals, Hypoxia, Dendritic Cells, Granulocytes, Homeostasis, Humans, Immunity, Innate, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Oxygen Consumption, Transcription Factors, Signal Transduction, Cell Hypoxia, Disease Progression, Myeloid Cells, Hypoxia-Inducible Factor 1, Host-Pathogen Interactions

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