The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma.
Open accessAbstract
The immunological mechanisms underlying the susceptibility to disseminated visceral parasitism of mononuclear phagocytes in patients with kala-azar remain undefined. Resistance and susceptibility are correlated with distinct patterns of cytokine production in murine models of disseminated leishmanial disease. To assess lesional cytokine profiles in patients with kala-azar, bone marrow aspirates were analyzed using a quantitative reverse transcriptase PCR technique to amplify specific mRNA sequences of multiple Th1-, Th2-, and/or macrophage-associated cytokines. Transcript levels of IL-10 as well as IFN-gamma were significantly elevated in patients with active visceral leishmaniasis; IL-10 levels decreased markedly with resolution of disease. These findings suggest that IL-10, a potent, pleiotropic suppressor of all known microbicidal effector functions of macrophages, may contribute to the pathogenesis of kala-azar by inhibiting the cytokine-mediated activation of host macrophages that is necessary for the control of leishmanial infection.
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Cited by
Interleukin-10 and the Interleukin-10 Receptor
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Metadata
- Authors
- Karp, C. L., el-Safi, S. H., Wynn, T. A., Satti, M. M., Kordofani, A. M., Hashim, F. A., Hag-Ali, M., Neva, F. A., Nutman, T. B., & Sacks, D. L.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-04-01
- Volume
- 91
- Issue
- 4
- Pages
- 1644-1648
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2070588564
- Cited by
- 340
- References
- 33
- FWCI
- 24.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. https://app.cochat.ai/papers/10.1172/jci116372
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- Karp, C. L., el-Safi, S. H., Wynn, T. A., Satti, M. M., Kordofani, A. M., Hashim, F. A., Hag-Ali, M., Neva, F. A., Nutman, T. B., & Sacks, D. L. (1993). In vivo cytokine profiles in patients with kala-azar. Marked elevation of both interleukin-10 and interferon-gamma. Journal of Clinical Investigation. https://doi.org/10.1172/jci116372
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