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The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis.
Open accessAbstract
We have previously characterized an activity from human plasma that markedly stimulates triglyceride synthesis in cultured human skin fibroblasts and human adipocytes. Based on its in vitro activity we named the active component acylation stimulating protein (ASP). The molecular identity of the active serum component has now been determined. NH2-terminal sequence analysis, ion spray ionization mass spectroscopy, and amino acid composition analysis all indicate that the active purified protein is a fragment of the third component of plasma complement, C3a-desArg. As well, reconstitution experiments with complement factors B, D, and complement C3, the components necessary to generate C3a, have confirmed the identity of ASP as C3a. ASP appears to be the final effector molecule generated by a novel regulatory system that modulates the rate of triglyceride synthesis in adipocytes.
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Citations
Cited by
Adipose Tissue as an Endocrine Organ
Kershaw, E. E., & Flier, J. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0395 · Cited by 5,522
Dyslipidemia in obesity: Mechanisms and potential targets
Klop, B., Elte, J., & Cabezas, M. (2013) · Nutrients · doi:10.3390/nu5041218 · Cited by 1,665
“intracellular esterification into TG [21,22].”
Regulation of Adipose Cell Number in Man
Prins, J. B., & O'rahilly, S. (1997) · Clinical Science · doi:10.1042/cs0920003 · Cited by 406
The autocrine and paracrine roles of adipokines
Karastergiou, K., & Mohamed-Ali, V. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.11.011 · Cited by 233
Complement activation in factor D-deficient mice
Xu, Y., Ma, M., Ippolito, G. C., Schroeder, H. W., Carroll, M. C., & Volanakis, J. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261428398 · Cited by 198
Metadata
- Authors
- Baldo, A., Sniderman, A. D., St-Luce, S., Avramoglu, R. K., Maslowska, M., Hoang, B., Monge, J. C., Bell, A., Mulay, S., & Cianflone, K.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-09-01
- Volume
- 92
- Issue
- 3
- Pages
- 1543-1547
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2074216064
- Cited by
- 221
- References
- 0
- FWCI
- 4.62
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Baldo, A., Sniderman, A. D., St-Luce, S., Avramoglu, R. K., Maslowska, M., Hoang, B., Monge, J. C., Bell, A., Mulay, S., & Cianflone, K. (1993). The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. Journal of Clinical Investigation. https://doi.org/10.1172/jci116733
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
