The autocrine and paracrine roles of adipokines
Open accessAbstract
Obesity, defined by an excess of adipose tissue, is often associated with the development of various metabolic diseases. The increased and inappropriate deposition of this tissue contributes to hyperglycemia, hyperlipidemia, insulin resistance, endothelial dysfunction and chronic inflammation. Recent evidence suggests that factors expressed and secreted by the adipose tissue, adipokines, may contribute to the development of these abnormalities by mechanisms including inhibition of adipogenesis, adipocyte hypertrophy and death, immune cell infiltration and disruption of tissue metabolism. The presence of adipokine receptors in adipocytes renders these cells available to autocrine and paracrine effects of adipokines. In this review the reported local effects of adipokines on adipose tissue structure, inflammation and regulation of metabolic functions, in the face of over-nutrition and consequent obesity, are outlined. Elucidating the local regulation of white adipocyte development and function could help in the design of effective, tissue-specific therapies for obesity-associated diseases.
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In 2120 Finns, CRP levels were associated with obesity indices and physical activity in both sexes.
“CRP levels in 2120 Finns were associated with obesity indices and physical activity among both sexes (247) ; in multivariate analyses, the determinants of CRP concentration included obesity and smoking in men, and obesity, oral contraceptive use and physical activity in women.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [247]
About one in three healthy women using oral contraceptives had CRP concentration exceeding 3 mg/l.
“The study showed that about one in three of healthy women who used oral contraceptives had a CRP concentration exceeding 3 mg/l, which should be taken into account when studying younger females.”
From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [247]
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“Obesity is characterized by persistent, low-level inflammation in adipose tissue, accompanied by the excessive production of pro-inflammatory adipokines [55, 56].”
BackgroundMallia, I., Fioravanti, A., & Guiducci, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110408 · Cited by 14 · see citing works
- Authors
- Karastergiou, K., & Mohamed-Ali, V.
- Affiliations
- St George's, University of London (GB)
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 318
- Issue
- 1-2
- Pages
- 69-78
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2090228141
- Cited by
- 233
- References
- 184
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 11 · 2023: 16 · 2022: 17 · 2021: 14 · 2020: 17 · 2019: 14 · 2018: 5 · 2017: 14 · 2016: 12 · 2015: 17 · 2014: 13 · 2013: 22 · 2012: 14
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- Wellcome Trust (GR078055MA)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipokines, obesity, autocrine signaling, paracrine signaling, adipose tissue, adipogenesis, adipocyte hypertrophy, adipocyte death, immune cell infiltration, chronic inflammation, insulin resistance, hyperglycemia, hyperlipidemia, endothelial dysfunction, adipokine receptors, white adipocytes, metabolic disorders, overnutrition
- MeSH terms
- Adipose Tissue, Animals, Humans, Autocrine Communication, Paracrine Communication, Adipokines
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